Results 51 to 60 of about 166,294,980 (268)

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

A bacterial route for folic acid supplementation

BMC Biology, 2018
Background To prevent folate deficiencies, many countries supplement various foodstuffs with folic acid. This compound is a synthetic oxidised folate that differs from naturally occurring reduced folates in its metabolism and uptake.
Claire Maynard, Ian Cummins, Jacalyn Green, David Weinkove   +3 more
doaj   +1 more source

Arginine methylation as a regulatory ratchet in cancer: From substrate selection to malignant‐state stabilization

Molecular Oncology, EarlyView.
Arginine methylation can be viewed as a persistence‐prone post‐translational modification regulated by a network of PRMTs. Competitive and compensatory interactions among PRMTs can redistribute methylation across substrate pools shaped by sequence, structural, spatial, and environmental layers, reinforcing RNA‐processing, chromatin, and signaling ...
So Hyun Kwon, Ji Min Lee
wiley   +1 more source

Green production of multi-functional carbon dots from agricultural corn silk waste: application in heavy metal (Fe3+/Cu2+) fluorometric sensing and in vitro cytotoxicity

Scientific Reports
Corn silk (CS), an abundant agricultural waste, is typically converted into carbon dots (CDs) through energy-intensive methods such as hydrothermal treatment and microwave-assisted synthesis.
Dina Abdelmonsef, Sherif Hammad, Mohsen Ghali   +2 more
doaj   +1 more source

NAPRT loss promotes lung tumor initiation and growth through AKT signaling independently of NAD+ biosynthesis

Molecular Oncology, EarlyView.
Loss of NAPRT promotes lung tumor initiation and growth through a noncanonical mechanism, independent of its role in NAD+ biosynthesis. Mechanistically, NAPRT depletion activates the mTORC2‐driven AKT/β‐catenin signaling axis to enhance clonogenic and invasive phenotypes. Furthermore, lung‐specific Naprt deletion significantly increases tumor burden in
Myung Joon Oh, Ji Yun Jang, Yoon Jeon, Gi‐Cheon Kim, Hwanho Lee, Jooyoung Lee, Ju‐Hwa Kim, Hakhyun Kim, Minjee Kim, Ho‐Keun Kwon, Ho Lee, Hyun Seok Kim   +11 more
wiley   +1 more source

Synthetic Biology of Antimicrobial Discovery

, 2012
Antibiotic discovery has a storied history. From the discovery of penicillin by Sir Alexander Fleming to the relentless quest for antibiotics by Selman Waksman, the stories have become like folklore used to inspire future generations of scientists ...
Zakeri, Bijan, Lu, Timothy K.
core   +1 more source

Integrated CO2 capture and conversion into methanol units: Assessing techno-economic and environmental aspects compared to CO2 into SNG alternative

Journal of CO2 Utilization
Using carbon dioxide (CO2) as a raw-material to produce value-added chemicals has a strategic role to play in the decarbonization of energy resources and the transition to a climate-neutral economy.
Rania Djettene, Lionel Dubois, Marie-Eve Duprez, Guy De Weireld, Diane Thomas   +4 more
doaj   +1 more source

Effects of IGFBP4 deficiency on human preadipocyte proliferation and differentiation through the IGF1R/AKT pathway

FEBS Open Bio, EarlyView.
IGFBP4 knockdown (KD) impairs preadipocyte proliferation and is associated with IGF1R protein downregulation and attenuated AKT phosphorylation. The mechanisms by which IGFBP4 KD influences the IGF1R/AKT signaling pathway involve newly synthesized proteins and lysosomal degradation pathways. Created in BioRender.
Yujia Guo, Sandy Richter, Christoph Bach, Wieland Kiess, Anna Kirstein, Diana Le Duc, Antje Garten   +6 more
wiley   +1 more source

Making Better Decisions During Synthetic Route Design: Leveraging Prediction to Achieve Greenness-by-Design [PDF]

, 2019
This paper expands our work predicting Process Mass Intensity (PMI), as a methodology for exploring the potential efficiency of proposed synthetic routes.
Jun, Li, Martin, Eastgate
core   +2 more sources

Synthesis of Poly(1,4‐anthraquinone) Using Catalytic Amounts of Nickel

Advanced Science
Multivalent metal batteries are attractive options to diversify energy storage options offering higher sustainability, but the high charge density of multivalent ions poses challenges to electrode materials.
Florin Adler, Sebastián Pinto‐Bautista, Christoph Lorenz, Lars Hinrichs, Marcel Weil, Birgit Esser   +5 more
doaj   +1 more source