Results 71 to 80 of about 166,294,980 (268)

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source

Data-Driven Approach for Passenger Assignment in Urban Rail Transit Networks: Insights From Passenger Route Choices and Itinerary Choices

Journal of Advanced Transportation
Congestion in urban rail transit (URT) systems often results in passengers being left behind on platforms due to trains’ reaching capacity. Distinguishing between the travel choice behaviors of passengers who board the first arriving train (Type I ...
Di Wen, Hongxia Lv, Hao Yu
doaj   +1 more source

Re‐Purposing Sapropterin (Kuvan) for ACTA2‐Related Multisystemic Smooth Muscle Dysfunction Syndrome: A Translational Mechanistic and First‐In‐Human Therapeutic Report

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Multisystemic smooth muscle dysfunction syndrome (MSMDS) is an ultra‐rare, ACTA2‐related disorder characterized by severe cerebrovascular disease, aortic aneurysms, and smooth muscle dysfunction. Using molecular dynamics simulations and in silico drug screening, we identified that sapropterin dihydrochloride (Kuvan) is a candidate capable of ...
Moran Hausman‐Kedem, Noa Bielopolski, Vijai Krishnan, Shane Wald‐Altman, Shelly I Shrian, Omer Bar‐Yosef, Livia Kapusta, Claire Shamber, Patricia L. Musolino, Miguel Weil   +9 more
wiley   +1 more source

Impact Toolbox

The Impact Toolbox by the Evaluating Societal Impact project is a catalogue of tools and methods that helps university staff select resources for a structured approach to academic impact ambitions, activities and assessment.The collection draws upon a ...
Evaluating Societal Impact
core   +1 more source

l-Proline catalyzed synthesis of biologically promising heterocycles under sustainable conditions

Tetrahedron Chem
Catalysis field wherein a tiny organic molecule like l-proline is an efficient and selectively catalyzed organic reaction. Catalyst-supported organic synthesis is confirmed to be involved in the fast synthesis of novel compounds with selectivity and ...
Rajiv Karmakar, Chhanda Mukhopadhyay
doaj   +1 more source

Towards Defect Phase Diagrams: From Research Data Management to Automated Workflows

Advanced Engineering Materials, EarlyView.
A research data management infrastructure is presented for the systematic integration of heterogeneous experimental and simulation data required for defect phase diagrams. The approach combines openBIS with a companion application for large‐object storage, automated metadata extraction, provenance tracking and federated data access, thereby supporting ...
Khalil Rejiba, Sang‐Hyeok Lee, Christina Gasper, Martina Freund, Sandra Korte‐Kerzel, Ulrich Kerzel   +5 more
wiley   +1 more source

Impact Competence Catalogue

This tool presents a selection of competences that are relevant for societal impact. The content is presented as a non-exhaustive list of competences that academics can develop for impact-oriented academic activities.
Evaluating Societal Impact
core   +1 more source

Current Status and Challenges in Data Collection for Aerospace Coatings Deposited by Plasma Spraying

Advanced Engineering Materials, EarlyView.
An innovative approach has been integrated into the GRENAT project to optimize plasma spraying and coating performance. Raw materials are accelerated and melted in the plasma generated by torches, creating coatings. Monitoring sensors collect process data which are combined with ex situ characterization data.
Lila Randriamananjara, Vincent Rat, Quentin Dubreuil, Patrice Valorge, Simon Goutier, Alain Denoirjean, Olivier Messe, Céline Ruelle, Jean‐Philippe Poli   +8 more
wiley   +1 more source

Synthesis of the Ammonium Salt of 6-Amino-2-hydroxy- 3,5-dinitropyrazine and a Comparison of its Properties with those of Ammonium 3,5-Diaminopicrate (ADAP) [PDF]

, 2009
The ammonium salt of 6-amino-2-hydroxy-3,5-dinitropyrazine has been synthesised from 2,6-dimethoxy-3,5-dinitropyrazine and its properties [DSC, crystal structure, impact sensitiveness, thermochemical properties] are compared with the analogous benzene ...
Padfield, James, Contini, Alessandro E., Golding, Peter, Anthony J. Bellamy, Peter Golding, James Padfield, Mary F. Mahon, Bellamy, Anthony J., Mahon, Mary F., Alessandro E. Contini   +9 more
core   +1 more source

Tetrakis(oxadiazolyl)benzenes and -Pyrazines: Novel Fluorescent Cruciform Liquid Crystals

Chemistry
This study investigates the fluorescent and mesomorphic properties of tetrakis(oxadiazolyl)benzenes (TOBEs) and -pyrazines (TOPYs), novel cruciform liquid crystals. The impact of a set of four side chains on optical and mesomorphic properties is reported.
Vincent Graschtat, Nico Achenbach, Matthias Lehmann, Heiner Detert   +3 more
doaj   +1 more source