Results 71 to 80 of about 287,814 (303)

Immunogenic properties of synthetic peptides copying the V3 loop of HIV-1 gp120 envelope protein: effects of various administration routes and poly(I:C) immunoadjvant use

Медицинская иммунология
Synthetic peptides provide a promising basis for HIV vaccine development. Following their administration, the immune response is focused only on a specific epitope. Moreover, they are able to activate both humoral and cellular pathways of immune response,
S. V. Korobova, V. A. Toporova, B. I. Alkhazova, M. E. Golovina, P. G. Aparin   +4 more
doaj   +1 more source

Cell-free prediction of protein expression costs for growing cells [PDF]

, 2017
Translating heterologous proteins places significant burden on host cells, consuming expression resources leading to slower cell growth and productivity.
Borkowski, O, Bricio, C, Ellis, T, Murgiano, M, Rothschild-Mancinelli, B, Stan, G   +5 more
core   +5 more sources

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

The cosmological Lithium problem outside the Galaxy: the Sagittarius globular cluster M54

, 2014
The cosmological Li problem is the observed discrepancy between Li abundance, A(Li), measured in Galactic dwarf, old and metal-poor stars (traditionally assumed to be equal to the initial value A(Li)_0), and that predicted by standard Big Bang ...
Bonifacio, P., Monaco, L., Mucciarelli, A., Salaris, M., Villanova, S.   +4 more
core   +3 more sources

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

A bacterial route for folic acid supplementation

BMC Biology, 2018
Background To prevent folate deficiencies, many countries supplement various foodstuffs with folic acid. This compound is a synthetic oxidised folate that differs from naturally occurring reduced folates in its metabolism and uptake.
Claire Maynard, Ian Cummins, Jacalyn Green, David Weinkove   +3 more
doaj   +1 more source

Trajectory Aware Macro-cell Planning for Mobile Users

, 2015
We design and evaluate algorithms for efficient user-mobility driven macro-cell planning in cellular networks. As cellular networks embrace heterogeneous technologies (including long range 3G/4G and short range WiFi, Femto-cells, etc.), most traffic ...
Bhattacharya, Arnab, Kokku, Ravi, Kolar, Vinay, Mitra, Shubhadip, Raghavan, Sriram, Ranu, Sayan, Telang, Aditya   +6 more
core   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Hybrid Varieties for Organic Cereals? Prospects and acceptance of hybrid breeding for organic production [PDF]

, 2006
Hybrid breeding utilizes the advantages characterizing F1 plants in a targeted manner: Vigour, uniformity, and a combination of all dominant traits of the parental lines.
Arncken, Christine, Dierauer, Hansueli
core  

C2α‐carbanion‐protonating glutamate discloses tradeoffs between substrate accommodation and reaction rate in actinobacterial 2‐hydroxyacyl‐CoA lyase

FEBS Open Bio, EarlyView.
Enzymes of the 2‐hydroxyacyl‐CoA lyase group catalyze the condensation of formyl‐CoA with aldehydes or ketones. Thus, by structural adaptation of active sites, practically any pharmaceutically and industrially important 2‐hydroxyacid could be biotechnologically synthesized. Combining crystal structure analysis, active site mutations and kinetic assays,
Michael Zahn, Barbara Seroka, Ryszard Lazny, Zenon Lotowski, Thore Rohwerder   +4 more
wiley   +1 more source