Results 61 to 70 of about 166,294,980 (268)
FEBS Open Bio, EarlyView.The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley +1 more source
Synthetic Route of Trithiolato-Bridged Dinuclear Arene Ruthenium(II) Complexes [(η6-P-MeC6H4Pri)2Ru2(μ2-SR)3]+ [PDF]
, 2020 Several dinuclear thiophenolato-bridged arene ruthenium complexes [(η6-p-MeC6H4Pri)2Ru2(μ2-SC6H4-R)3]+ could so far onlybe obtained with moderate yields using the synthetic route established in the early 2000s.
Mario de, Capitani +5 more
core +2 more sources
Frontiers in Environmental ScienceThe acceleration of urbanization and the impact of climate change have led to an increasing frequency and intensity of grassland fires, posing severe challenges to resident safety and ecological protection.
Ziyang Zhang +2 more
doaj +1 more source
GelMA‐based 3D spheroids recapitulate transcriptomic and functional hallmarks of myeloid sarcoma
FEBS Open Bio, EarlyView.GelMA 5% hydrogels support the formation of myeloid leukemia spheroids that recapitulate MS‐specific features, including G1 arrest, apoptosis, and ECM‐driven transcriptomic reprogramming. The 3D model mimicked soft‐tissue‐like stiffness and oxygen conditions, and transcriptomic convergence with primary MS samples confirmed its utility as a preclinical ...
Nicolas Germain +11 more
wiley +1 more source
Degradation of Synthetic-Based Drilling Mud Base Fluids by Gulf of Mexico Sediments: Final Report [PDF]
, 2006 Report on a predictor model that determines the degradation rate of Synthetic-based fluids (SBF) from deep-sea drilling and assesses the impact of SBFs on the sediment microbial ecology in the Gulf of ...
Roberts, Deborah J., Nguyen, Alan H.
core
Synthetic route of mannose-modified chitosan derivatives.
, 2022 Synthetic route of mannose-modified chitosan derivatives.
Ying Zhao (16546) +8 more
core +1 more source
BCG vaccination potentiates oxidative phosphorylation in neonatal myeloid‐derived suppressor cells
FEBS Open Bio, EarlyView.BCG vaccination enhances oxidative phosphorylation in neonatal MDSCs, impairing their immunosuppressive function. It upregulates electron transport chain genes and mitochondrial activity, increasing ATP and oxygen consumption. Pharmacological OXPHOS inhibition partially restores suppressive capacity, confirming causality.
Yingying Chen, Hui Li
wiley +1 more source
Principles of synthetic biology: a MOOC for an emerging field
, 2020 Synthetic biology requires students and scientists to draw upon knowledge and expertise from many disciplines. While this diversity is one of the field’s primary strengths, it also makes it challenging for newcomers to acquire the background knowledge ...
Weiss, Ron +2 more
core +1 more source
FEBS Open Bio, EarlyView.TGF‐β1 stimulation downregulates lysosomal channel TRPML1 in pulmonary fibroblasts. The TRPML1 agonist ML‐SA5 suppressed fibroblast‐to‐myofibroblast activation and collagen production. Mechanistically, ML‐SA5 inhibited mTOR phosphorylation, restored autophagic flux, and its effects were enhanced by rapamycin (mTOR inhibitor) and reversed by MHY1485 ...
Jiatong Yao +10 more
wiley +1 more source
A Portfolio Theory of Route Choice [PDF]
Although many individual route choice models have been proposed to incorporate travel time variability as a decision factor, they are typically still deterministic in the sense that the optimal strategy requires choosing one particular route that ...
Shanjiang Zhu, David Levinson
core