Results 71 to 80 of about 1,129,217 (278)

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

open access: yesFEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li   +2 more
wiley   +1 more source

Modeling impact on aluminium sandwich including velocity effects in honeycomb core [PDF]

open access: yes, 2013
A numerical model has been developed on metallic sandwich structures as an armor for aeronautical applications. Several combinations of AA5086-H111 aluminium skins and aluminium honeycomb core have been studied, considering medium-velocity and highenergy
Alvarado, Raquel   +3 more
core   +4 more sources

Impact resistance of gypsum board subjected to low velocity impact

open access: yesTehnicki vjesnik - Technical Gazette, 2017
The aim of this study was to investigate the impact resistance and damage behaviour of gypsum and composite gypsum boards subjected to low velocity impact. Low velocity impact tests were performed on four different board materials which can be listed as gypsum boards, gypsum+75 gr/m² mesh boards, gypsum+wallpaper boards and gypsum+75 gr/m² mesh ...
Kara, Memduh   +2 more
openaire   +4 more sources

Cell wall target fragment discovery using a low‐cost, minimal fragment library

open access: yesFEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan   +5 more
wiley   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

open access: yesFEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee   +3 more
wiley   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

An Innovative Model to Determine Damping Ratio based on an Experimental Test during Collision [PDF]

open access: yesJournal of Rehabilitation in Civil Engineering
This study investigates the damping ratio to evaluate impact force and energy absorption during collisions between adjacent buildings under seismic excitation.
Seyed Mohammad Khatami   +4 more
doaj   +1 more source

Self-diffusion in granular gases

open access: yes, 1999
The coefficient of self-diffusion for a homogeneously cooling granular gas changes significantly if the impact-velocity dependence of the restitution coefficient $\epsilon$ is taken into account. For the case of a constant $\epsilon$ the particles spread
B. J. Berne   +29 more
core   +1 more source

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

open access: yesMolecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou   +5 more
wiley   +1 more source

Influence of impact velocities of hammer crusher on crushing effect and utilization efficiency of fracture energy in green sandstone

open access: yesMeitan kexue jishu
The impact velocities of hammer crusher directly affect the crushing effect of rock. In order to study influence of impact velocities of hammer head on the crushing effect and utilization efficiency of fracture energy in green sandstone, macroscopic and ...
Huanshuai ZHAO   +6 more
doaj   +1 more source

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