Results 51 to 60 of about 1,370,091 (259)

Neurochemical Endpoints to Inform Early‐Stage Trials of Spinocerebellar Ataxia 2 and 3 in a Multisite Setting

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Neurochemical levels measured by brain MR spectroscopy (MRS) have been proposed as endpoints for clinical trials in early‐stage spinocerebellar ataxia (SCA) trials. We tested their trial‐readiness by quantifying neurochemicals in three affected brain regions in early‐stage cohorts of SCA2 and SCA3, examining their reproducibility in ...
James M. Joers, Yaqiao Wei, Dinesh K. Deelchand, Adam Berrington, Young Woo Park, Guita Banan, Michal Povazan, Jens T. Rosenberg, André J. W. van der Kouwe, Tetsuo Ashizawa, Khalaf O. Bushara, Chiadi U. Onyike, Sub H. Subramony, Jeremy D. Schmahmann, Brian J. Soher, Peter B. Barker, Thomas H. Mareci, Eva‐Maria Ratai, Lynn E. Eberly, Gülin Öz   +19 more
wiley   +1 more source

Diabetes and hypertension in urban bhutanese men and women

Indian Journal of Community Medicine, 2013
Background: Bhutan is a mountainous country with 31% urban population. There is no information on prevalence of diabetes and hypertension in Bhutan yet. This was the first study of its kind conducted in the capital city.
Bhakta Raj Giri, Krishna Prasad Sharma, Rup Narayan Chapagai, Dorji Palzom   +3 more
doaj   +1 more source

Association between serum hydrogen sulfide concentrations and dysglycemia: a population-based study

BMC Endocrine Disorders, 2022
Background and aim Hydrogen sulfide (H2S), a signaling gasotransmitter, is involved in carbohydrate metabolism. Here, we aimed to assess the potential association between serum H2S and dysglycemia in the framework of a population-based study.
Zahra Bahadoran, Sajad Jeddi, Parvin Mirmiran, Khosrow Kashfi, Fereidoun Azizi, Asghar Ghasemi   +5 more
doaj   +1 more source

Digital Cognitive Phenotyping for Differential Diagnosis and Monitoring in Neurological Conditions

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To assess the utility, accessibility, and equivalence to supervised scales of online cognitive assessment in older individuals with cognitive impairment. Methods Patients with Alzheimer's disease (AD, n = 31), idiopathic normal pressure hydrocephalus (iNPH, n = 26), and traumatic brain injury (TBI, n = 23) completed online cognitive ...
Martina Del Giovane, Valentina Giunchiglia, Michael C. B. David, Magdalena A. Kolanko, William R. Trender, Peter J. Hellyer, Harmeena Kaur, David J. Sharp, Christopher Carswell, Paresh A. Malhotra, Adam Hampshire   +10 more
wiley   +1 more source

Diabetes mellitus, fasting glucose, and risk of cause-specific death. [PDF]

, 2011
BACKGROUND: The extent to which diabetes mellitus or hyperglycemia is related to risk of death from cancer or other nonvascular conditions is uncertain. METHODS: We calculated hazard ratios for cause-specific death, according to baseline diabetes status ...
Mukamal, K.J., Seshasai, S. R., Stehouwer, Coen; id_orcid, Kaptoge, S., Gillum, Richard F, Gillum, R.F., Thompson, Alexander, Gudnason, Vilmundur, Emerging Risk Factors Collaboration, Danesh, J., Fletcher, Astrid, Lewington, S., di Angelantonio, E., Gao, P., Gudnason, V., Holme, Ingar, Mukamal, Kenneth J., Di Angelatino, E., Thompson, S. G., Thompson, S.G., Tybjærg-Hansen, Anne, Thompson, Simon G, Bladbjerg, Else-Marie; id_orcid, Kromhout, D., Selvin, E., Emerging Risk Factors Collabora, Frikke-Schmidt, Ruth, Hu, F. B., Seshasai, Sreenivasa Rao Kondapally, Gillum, Richard F., Kaptoge, Stephen, Fletcher, A., Hu, F.B., Eriksson, Henry,, Sarwar, Nadeem, null null, Mukamal, Kenneth J, Njølstad, Inger, Collins, Rory, Benn, Marianne, Thompson, A., Hu, Frank B, Whincup, P.H., Lewington, Sarah, Gillum, R. F., Sattar, N., Angelantonio, E. di, Seshasai, S.R., Nilsson, P., Rao Kondapally Seshasai, Sreenivasa, Holme, I., Sarwar, N., Danesh, John, Whincup, P. H., Seshasai, S.R.K., Njolstad, Inger, Njølstad, I., Whincup, Peter H, Selvin, Elizabeth, Di Angelantonio, Emanuele, Nilsson, Peter, Mukamal, K. J., Emerging Risk Factors Collaboration (Döring, A. ; Meisinger, C.), Njolstad, I., Sattar, Naveed, Collins, R., Jespersen, Jørgen; id_orcid, Nordestgaard, Børge G., Hu, Frank B., Gao, Pei, Whincup, Peter H., Thompson, Simon G., Nilsson, Carl Martin Peter, Lund University., Nilsson, Peter,   +74 more
core   +1 more source

Diabetes‐Associated Cognitive Impairment: Pathophysiology and Emerging Therapies

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Diabetes‐associated cognitive impairment (DACI) is a common yet underrecognized condition, manifesting along a spectrum from mild cognitive impairment to dementia. DACI encompasses patients who develop vascular dementia (VaD) or Alzheimer's disease (AD) with diabetes as a risk factor; however, in certain patients, particularly those lacking ...
Osman Corbali, Priyanka Menon, Halil I. Corbali, Ram Jagannathan, Allan I. Levey   +4 more
wiley   +1 more source

Association of HDL/TG Ratio as an Insulin Resistance Marker with Various Levels of Fasting Blood Glucose

Medical Laboratory Journal, 2016
Background and Objective: The association of Triglyceride/High Density Lipoprotein-Cholesterol (TG/HDL-C) ratio with fasting serum insulin, which is an alternative method of insulin resistance (IR) measurement, is well-recognized.
Maryam MoradiBinabaj, Mohadese Namjoo, Mojgan Nejabat, Hamidreza Joshaghani   +3 more
doaj  

Prevalence of impaired glucose tolerance in ischemic Egyptian patients

The Egyptian Heart Journal, 2013
Background and aim: Prediabetes (impaired glucose tolerance or impaired fasting glucose) is usually associated with a higher health risk profile for cardiovascular diseases.
I.M. Attia, H.I. Ragy, B.E. Enany, I.M. Elgamal   +3 more
doaj   +1 more source

Testosterone is protective against impaired glucose metabolism in male intrauterine growth-restricted offspring. [PDF]

PLoS ONE, 2017
Placental insufficiency alters the intrauterine environment leading to increased risk for chronic disease including impaired glucose metabolism in low birth weight infants.
Suttira Intapad, John Henry Dasinger, Joel M Fahling, Miles A Backstrom, Barbara T Alexander   +4 more
doaj   +1 more source

Glucagon‐Like Peptide‐1 Receptor Agonists in Multiple Sclerosis: A Topical Narrative Review

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT The glucagon‐like peptide‐1 (GLP‐1) receptor agonists (RAs) are a relatively new class of drugs that were initially approved by the US Food and Drug Administration to improve glycemic control in patients with type 2 diabetes mellitus and, subsequently, weight reduction in patients with obesity.
Audrey Y. Chang, Farrah J. Mateen
wiley   +1 more source