Results 31 to 40 of about 1,754,919 (302)

Loss of AMP-activated protein kinase alpha 2 subunit in mouse beta-cells impairs glucose-stimulated insulin secretion and inhibits their sensitivity to hypoglycaemia [PDF]

, 2010
AMPK (AMP-activated protein kinase) signalling plays a key role in whole-body energy homoeostasis, although its precise role in pancreatic beta-cell function remains unclear.
Withers, DJ, Ashford, ML, Smith, Mark A., Al-Qassab, H, Piipari, K, Piipari, Kaisa, Al-Qassab, Hind, Smith, Mark A, Viollet, Benoit, Ashford, Michael Lj, Viollet, B, Beall, Craig, Smith, MA, Withers, Dominic J, Parker, N, Carling, David, Parker, Nadeene, Withers, Dominic J., Ashford, Michael L. J.; id_orcid, Beall, C, Carling, D   +20 more
core   +1 more source

Insulin secretion and impaired glucose tolerance [PDF]

Diabetologia, 2010
To the Editor: The recent publication in Diabetologia ofbaseline results from two large-scale longitudinal studiesprovides welcome confirmation of the association ofimpaired beta cell function and glucose intolerance outsidethe diabetic range and promises useful information whenfollow-up studies are completed regarding factors related toprogression of ...
A B, Jenkins, L V, Campbell
openaire   +2 more sources

Diabetes status and post-load plasma glucose concentration in relation to site-specific cancer mortality: findings from the original Whitehall study [PDF]

, 2004
ObjectiveWhile several studies have reported on the relation of diabetes status with pancreatic cancer risk, the predictive value of this disorder for other malignancies is unclear.
Batty, G.D., Batty, GD, Shipley, M.J., Davey Smith, G., Marmot, M., Marmot, M, Davey Smith, G, Shipley, MJ, G. David. Batty, Michael Marmot, George Davey Smith, Martin J. Shipley   +11 more
core   +1 more source

High cardiorespiratory fitness is more beneficial in pre-diabetic men than women

Clinics, 2011
OBJECTIVES: To investigate gender-specific relationships between cardiorespiratory fitness and factors that predict the development of diabetes and to identify the risk factors that predict fasting plasma glucose and 2-hour plasma glucose levels ...
Hannes Gatterer, Hanno Ulmer, Alexander Dzien, Matthias Somavilla, Martin Burtscher   +4 more
doaj   +1 more source

Carbohydrate Metabolism Disorders in Patients with Chronic Pancreatitis

Mìžnarodnij Endokrinologìčnij Žurnal, 2014
This article deals with dependence of the carbohydrate metabolism disorders on the duration of disease in patients with non-destructive chronic pancreatitis.
S.I. Ismailov, F.G. Nazyrov, B.A. Azizov
doaj   +1 more source

Hypoxia exposure alleviates impaired muscular metabolism, glucose tolerance, and aerobic capacity in apelin-knockout mice

, 2019
High altitude hypoxia adaptation can improve glucose tolerance in people with metabolic syndrome and type 2 diabetes (T2D). Apelin is an endogenous ligand of the G protein-coupled receptor APJ and has possible roles in energy metabolism. Apelin-null mice
He, Shiyi, Li, Junping, Zhang, Ying, Wang, Jianxiong   +3 more
core   +1 more source

Atherosclerosis in 64-year-old women with diabetes mellitus and impaired glucose tolerance [PDF]

, 2006
Atherosclerosis in 64-year-old women with diabetes mellitus and impaired glucose tolerance The incidence of obesity and type-2 diabetes (t2D) is rising around the world. T2D is accompanied by an increased risk of macrovascular, atherosclerotic diseases.
Brohall, Gerhard, Fagerberg, Björn,, Oden, A., Brohall, Gerhard,   +3 more
core   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

From Prediabetes to Type 2 Diabetes Mellitus in Women with Polycystic Ovary Syndrome: Lifestyle and Pharmacological Management

International Journal of Endocrinology, 2020
Aims. Despite the very clear association between polycystic ovary syndrome (PCOS) and dysglycemia, few studies have explored the continuum of glycemic alterations leading from minor glucose abnormalities to overt diabetes.
Arianna Pani, Ilaria Gironi, Giacoma Di Vieste, Elena Mion, Federico Bertuzzi, Basilio Pintaudi   +5 more
doaj   +1 more source

Associations of TG/HDL Ratio with the Risk of Prediabetes and Diabetes in Chinese Adults: A Chinese Population Cohort Study Based on Open Data

International Journal of Endocrinology, 2021
Background. In the global chronic diseases, type 2 diabetes shows a significant upward trend, and there are more people before prediabetes (impaired glucose tolerance).
Rongpeng Gong, Yuanyuan Liu, Gang Luo, Wenjing Liu, Ziqi Jin, Zixin Xu, Zheng Li, Lixin Yang, Xiaoxing Wei   +8 more
doaj   +1 more source