Results 51 to 60 of about 1,754,919 (302)
Unraveling the epigenetic code in cancer cell–tumor microenvironment crosstalk
Molecular Oncology, EarlyView.Epigenetic regulation is a key driver of cancer development and progression. Diverse epigenetic alterations in cancer cells and components of the tumor microenvironment (TME) orchestrate their communication through multiple mechanisms. We discuss how the epigenetic code coordinates bidirectional cancer cell–TME crosstalk to promote cancer progression ...
Ji Hoon Park, Mi‐Young Kim
wiley +1 more source
, 2005 Earlier studies have shown that individuals whose mothers were diabetic when they were in utero, have an increased risk of early obesity, and impaired glucose tolerance (lGT) and type 2 diabetes in adult life.
Krishnaveni, Ghattu Vedamurthy
core +1 more source
Frontiers in Endocrinology, 2021 ObjectiveThe purpose of this study was to observe the relationship between impaired fasting glucose (IFG), impaired glucose tolerance (IGT), and bone mineral density (BMD) in different sites in adolescents.MethodsA retrospective study was conducted on ...
Chun-Ming Ma, Fu-Zai Yin
doaj +1 more source
Molecular Oncology, EarlyView.Arginine methylation can be viewed as a persistence‐prone post‐translational modification regulated by a network of PRMTs. Competitive and compensatory interactions among PRMTs can redistribute methylation across substrate pools shaped by sequence, structural, spatial, and environmental layers, reinforcing RNA‐processing, chromatin, and signaling ...
So Hyun Kwon, Ji Min Lee
wiley +1 more source
Çukurova Üniversitesi Tıp Fakültesi Dergisi, 2013 Purpose: To examine the difference in terms of prenatal and perinatal characteristics between gestational diabetic (GDM) cases diagnosed with impaired fasting glucose (IFG)and impaired glucose tolerance (IGT) during early postpartum period.
Okan Bakiner +4 more
doaj
FREQUENCY OF IMPAIRED GLUCOSE TOLERANCE IN DIFFERENT GRADES OF OBESITY
Journal of University Medical & Dental College, 2020 Introduction Impaired glucose tolerance (IGT) is a pre-diabetic condition. It is defined as fasting glucose less than 7.0 mmol/l (25 were selected for this study.
Khalid Amin, Amin Anjum
doaj
Evolution‐guided yeast complementation reveals functional differences in human PSPH variants
FEBS Open Bio, EarlyView.Ancient genomes can help guide which human genetic variants are tested experimentally. This study applies that idea to PSPH, a gene involved in serine biosynthesis, and uses high‐throughput yeast complementation to compare variant function. The findings reveal measurable differences among selected alleles and illustrate the value of evolution‐guided ...
Mauricio Campa‐Álvarez +6 more
wiley +1 more source
The C‐terminal domain of yeast Arginyltransferase1 is essential for its catalytic activity
FEBS Open Bio, EarlyView.Arginyltransferase 1 (Ate1), a eukaryotic enzyme, catalyses arginylation, transferring arginine from tRNA‐Arg to the amino terminus of the target protein. Overexpression of Ate1 in yeast is lethal and is dependent on arginylation. This study elucidates how mutations in the cofactor‐binding and active site of Ate1 and truncation of its structural ...
Vikas Kumar Yadav +4 more
wiley +1 more source
Alteration of de novo glucose production contributes to fasting hypoglycaemia in fyn deficient mice [PDF]
, 2013 Previous studies have demonstrated that glucose disposal is increased in the Fyn knockout (FynKO) mice due to increased insulin sensitivity. FynKO mice also display fasting hypoglycaemia despite decreased insulin levels, which suggested that hepatic ...
Bastie, Claire C. +31 more
core +2 more sources
Predicting Metabolic Syndrome in Obese Children and Adolescents: Look, Measure and Ask
Obesity Facts, 2013 Objective: To verify in obese children whether or not the presence of i) high waist-to-height ratio (WHtR), ii) family history for type 2 diabetes (T2D) and iii) acanthosis nigricans (AN), singularly or together, might predict the occurrence of metabolic
Nicola Santoro +8 more
doaj +1 more source