Results 41 to 50 of about 1,754,919 (302)

Markers of dysglycaemia and risk of coronary heart disease in people without diabetes: Reykjavik prospective study and systematic review. [PDF]

, 2010
BACKGROUND: Associations between circulating markers of dysglycaemia and coronary heart disease (CHD) risk in people without diabetes have not been reliably characterised.
Aspelund, T, Nita G Forouhi, Thor Aspelund, Gobin, R, Danesh, J, Reeta Gobin, Seshasai, SR, Sigurdsson, G, Aspelund Thor, Sarwar, N, Vilmundur Gudnason, Seshasai Sreenivasa Rao Kondapally, Eiriksdottir, G, Sarwar Nadeem, Gudnason, V, Danesh John, John Danesh, Nadeem Sarwar, Gudnason Vilmundur, Eiriksdottir Gudny, Sigurdsson Gunnar, Gudny Eiriksdottir, Sreenivasa Rao Kondapally Seshasai, Gobin Reeta, Forouhi Nita G., Gunnar Sigurdsson, Forouhi, NG   +26 more
core   +1 more source

Discerning protein pools by selective staining with self‐labeling tags

FEBS Letters, EarlyView.
Cell surface proteins have an intra‐ and extracellular pool. Combining genetic fusion to self‐labeling tags that can be addressed with small molecule fluorophores allows separating these pools. We highlight recent developments and techniques for state‐of‐the‐art interrogation of cell surface proteins in the complex tissue setting.
Kati Fischermanns, Johannes Broichhagen
wiley   +1 more source

Impaired glucose tolerance and unidentified diabetes [PDF]

Postgraduate Medical Journal, 1996
Abstract The epidemiology of impaired glucose tolerance and undiagnosed non-insulin-dependent diabetes mellitus is reviewed and the implications for screening strategies discussed.
R J, Heine, J M, Mooy
openaire   +2 more sources

Prevention of diabetes and cardiovascular disease in patients with impaired glucose tolerance: Rationale and design of the Nateglinide And Valsartan in Impaired Glucose Tolerance Outcomes Research (NAVIGATOR) Trial

, 2008
Patients with impaired glucose tolerance (IGT) have increased risk for developing type 2 diabetes mellitus (T2DM) and cardiovascular disease (CVD). Lifestyle modification and medication can prevent or delay progression to diabetes (PD), but whether such ...
Haffner, SM, Boolell, M, Duggal, A, NAVIGATOR,, McMurray, JJ, Bethel, MA, Study Group,, Holman, RR, Bethel, M, McMurray, J, Califf, RM, Holman, Rury   +11 more
core   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Normal Glucose Tolerance with a High 1-Hour Postload Plasma Glucose Level Exhibits Decreased β-Cell Function Similar to Impaired Glucose Tolerance [PDF]

Diabetes & Metabolism Journal, 2015
BackgroundSubjects with normal glucose tolerance (NGT) who have a high 1-hour postload plasma glucose level (≥155 mg/dL; NGT 1 hour-high) have been shown to be at higher risk for type 2 diabetes than subjects with NGT 1 hour-low postload plasma glucose ...
Tae Jung Oh, Se Hee Min, Chang Ho Ahn, Eun Ky Kim, Soo Heon Kwak, Hye Seung Jung, Kyong Soo Park, Young Min Cho   +7 more
doaj   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Evidence From a Systematic Review and Meta-Analysis: Classical Impaired Glucose Tolerance Should Be Divided Into Subgroups of Isolated Impaired Glucose Tolerance and Impaired Glucose Tolerance Combined With Impaired Fasting Glucose, According to the Risk of Progression to Diabetes

Frontiers in Endocrinology, 2022
BackgroundThe American Diabetes Association (ADA) 2003 diagnostic criteria divide impaired glucose tolerance (IGT) into isolated impaired glucose tolerance with normal fasting glucose (I-IGT, IGT+NFG) and impaired glucose tolerance combined with impaired
Yupu Liu, Yupu Liu, Juan Li, Juan Li, Yuchao Wu, Yuchao Wu, Han Zhang, Qingguo Lv, Qingguo Lv, Yuwei Zhang, Yuwei Zhang, Xiaofeng Zheng, Xiaofeng Zheng, Nanwei Tong, Nanwei Tong   +14 more
doaj   +1 more source

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source

Impaired glucose tolerance in acute pancreatitis

World Journal of Gastroenterology, 2015
Acute pancreatitis (AP) is an acute inflammatory disease of the exocrine pancreas. In spite of the pivotal role of the endocrine pancreas in glucose metabolism, the impact of impaired glucose tolerance on AP has not been fully elucidated. A meta-analysis of seven observational studies showed that type 2 diabetes mellitus (DM) was associated with an ...
Kazuhiro, Kikuta, Atsushi, Masamune, Tooru, Shimosegawa   +2 more
openaire   +2 more sources