Results 61 to 70 of about 1,880,493 (302)

The anti-atherogenic effects of thiazolidinediones [PDF]

, 2007
The thiazolidinediones (TZDs) rosiglitazone (ROS) and pioglitazone (PIO) are insulin-sensitising agents widely used to treat patients with type 2 diabetes mellitus (T2DM). Thiazolidinediones significantly improve glycaemic control in diabetics by reduced
Stojanovska, Lily, Honisett, Suzy, Komesaroff, Paul A   +2 more
core   +5 more sources

Demographic and metabolic characteristics of individuals with progressive glucose tolerance

Brazilian Journal of Medical and Biological Research, 2009
We evaluated changes in glucose tolerance of 17 progressors and 62 non-progressors for 9 years to improve our understanding of the pathogenesis of type 2 diabetes mellitus. Changes in anthropometric measurements and responses to an oral glucose tolerance
A.L. Mendes, M.L. Santos, C.R. Padovani, W.P. Pimenta   +3 more
doaj  

Impaired fasting glucose and impaired glucose tolerance in rural central India: A study of prediabetes in the first degree relatives of patients with type 2 diabetes mellitus in a rural region of Malwa in Madhya Pradesh

National Journal of Physiology, Pharmacy and Pharmacology, 2017
Background: Prediabetes is a category of glucose tolerance representing an intermediate stage between normal glucose tolerance and diabetes and is characterized by impaired fasting glucose (IFG) and impaired glucose tolerance (IGT).
Abhilasha Dutta, Abhishek Kumar, S N Shukla, Amol Daniel   +3 more
doaj   +1 more source

Impaired glucose tolerance in acute pancreatitis

World Journal of Gastroenterology, 2015
Acute pancreatitis (AP) is an acute inflammatory disease of the exocrine pancreas. In spite of the pivotal role of the endocrine pancreas in glucose metabolism, the impact of impaired glucose tolerance on AP has not been fully elucidated. A meta-analysis of seven observational studies showed that type 2 diabetes mellitus (DM) was associated with an ...
Kazuhiro, Kikuta, Atsushi, Masamune, Tooru, Shimosegawa   +2 more
openaire   +2 more sources

Dual Role of Tamoxifen in Enhancing STING and CEACAM1 Expression to Prime a Favorable Tumor Microenvironment for Anti‐TIM3 Immunotherapy

Advanced Science, EarlyView.
Anti‐PD‐1/PD‐L1 blockade has revolutionized cancer immunotherapy, but is ineffective against endocrine‐treated (i.e., Tamoxifen), relapsed ER+ breast cancer (BC) patients. This study provides insight into the sub‐optimal response of ER+BCs to anti‐PD‐1/PD‐L1 blockade – highlighting the induction of STING and the CEACAM1/TIM3 axis after chronic ...
Marvin Angelo E Aberin, Saurabh Singh, Soumya Chatterjee, Guang‐Zhi Sui, Yi‐Fu Wang, Ya‐Ting Lu, Yu‐Ling Lee, Kun‐Yuan Lin, Joy Khag, Ta‐Yu Liu, Shao‐Han Chang, Wai‐Mui Cheung, Hsiao‐Chin Hong, Ren‐Jun Hsu, Chen‐Yang Shen, Chia‐Wei Li, Weng‐Lang Yang, Yao‐Ming Chang, Shih‐Yu Chen, Chandan Guha, Shu‐Ping Wang   +20 more
wiley   +1 more source

Occurrence and predictors of persistent impaired glucose tolerance after acute ischemic stroke or transient ischemic attack [PDF]

, 2014
Background Impaired glucose tolerance is often present in patients with a transient ischemic attack (TIA) or ischemic stroke and doubles the risk of recurrent stroke.
Hertog, H.M. (Heleen) den, Hertog, Heleen, Fonville, Susanne, Koudstaal, P.J. (Peter), Zandbergen, A.A.M. (Adrienne), Lingsma, H.F. (Hester), Koudstaal, Peter, Lingsma, Hester, Zandbergen, AAM (Adrienne)   +8 more
core   +1 more source

Coixenolide Enhances Antitumor Immunity of Cytotoxic CD8+ T Cells by Inhibiting S100A8/A9‐CD36 Axis in Obesity‐Associated Pancreatic Adenocarcinoma

Advanced Science, EarlyView.
Pancreatic adenocarcinoma (PAAD) remains highly lethal with limited treatment options. This study demonstrates that coixenolide, a bioactive compound from Coix lacryma‐jobi L. and a key component of the clinically approved Kanglaite injection, exhibits enhanced antitumor efficacy in high‐fat diet (HFD)‐induced obese mice bearing PAAD tumors compared to
Kaidi Chen, Rong Chen, Wei Li, Bin Song, Ruiying Zhang, Lewei Dai, Yuwei Qi, Ruqian Chen, Yifan Xu, Hangbin Li, Jingyi Huang, Fangping Wu, Jianan Peng, Xinyu Wang, Yang Xiong, Chaofeng Mu, Guilin Cheng, Zhaoshen Li, Shanming Ruan, Lei Huang, Mancang Gu   +20 more
wiley   +1 more source

Distinct β-Cell Defects in Impaired Fasting Glucose and Impaired Glucose Tolerance [PDF]

Diabetes, 2012
To characterize the defects in β-cell function in subjects with impaired fasting glucose (IFG) and compare the results to impaired glucose tolerance (IGT) and normal glucose tolerance (NGT) subjects, β-cell glucose sensitivity and rate sensitivity during the oral glucose tolerance test were measured with the model ...
Kanat M, Mari A, Norton L, Winnier D, DeFronzo RA, Jenkinson C, AbdulGhani MA   +6 more
openaire   +2 more sources

Impaired fasting glucose and impaired glucose tolerance in children and adolescents with overweight/obesity

, 2017
To investigate in a large sample of overweight/obese (OW/OB) children and adolescents the prevalence of prediabetic phenotypes such as impaired fasting glucose (IFG) and impaired glucose tolerance (IGT), and to assess their association with ...
Miraglia Del Giudice, E, Manco, M, Loche, S, Tornese, G, Morandi, A, Invitti, C, Chiesa, C, Valerio, G, Baroni, M G, Licenziati, M R, Franco, F, Maffeis, C, Di Bonito, P, Pacifico, L   +13 more
core   +1 more source

Rab1A Promotes Hepatic Steatosis by Suppressing Mitophagy via the Raf‐1/ERK1/2/PINK1 Signaling Axis

Advanced Science, EarlyView.
Why does fat accumulate in the liver? Our study reveals Rab1A as the molecular switch that silences the cell's mitochondrial cleanup crew. Turning Rab1A off reactivates mitophagy, clears excess fat, and reverses fatty liver disease in mice—offering a promising new therapeutic target for MASLD, a growing global health challenge.
Li Zhang, Jianhua Li, Huilu Zhang, Qi Qin, Yichen Huang, Xiaofan Tian, Chao Sun, Binbin Li, Zhengxin Wang, Xin Zhang   +9 more
wiley   +1 more source