Results 81 to 90 of about 264,143 (351)

Bioengineered Pancreatic Cancer Immunosuppressive Microenvironment Models for Screening Immunotherapies

Advanced Healthcare Materials, EarlyView.
Bioengineering tumor‐stroma pancreatic cancer models with potential to emulate the native immunosuppressive tumor microenvironment. Cancer‐on‐a‐bead models exhibited higher relevance for screening immunotherapies and modulating the protumoral PDAC microenvironment. ABSTRACT Pancreatic cancer is notably resistant to treatment, primarily due to its dense
Maria V. Monteiro, Margarida Henriques‐Pereira, Bruno M. Neves, Vítor M. Gaspar, João F. Mano   +4 more
wiley   +1 more source

Prevalence of impaired glucose tolerance in ischemic Egyptian patients

The Egyptian Heart Journal, 2013
Background and aim: Prediabetes (impaired glucose tolerance or impaired fasting glucose) is usually associated with a higher health risk profile for cardiovascular diseases.
I.M. Attia, H.I. Ragy, B.E. Enany, I.M. Elgamal   +3 more
doaj   +1 more source

A 3D Astrocyte Microenvironment Model Enables Rapid Ca2+‐Resolved Analysis and Therapeutic Modulation of Oxidative Neuroinflammation

Advanced Healthcare Materials, EarlyView.
This work presents ARC‐3D, a soft 3D model that recreates how brain support cells, called astrocytes, react to oxidative stress. The system visualizes rapid calcium changes and inflammatory signals, and shows how the drug KDS12025 can protect cells from damage. ARC‐3D offers a simple, reliable way to study early drivers of brain inflammation.
Ju‐Kang Kim, Ye‐Ji Kim, Seyoung Ryu, Daeui Park, Kyoung‐Sik Moon, Yu Bin Lee, Dong Ho Woo   +6 more
wiley   +1 more source

SERUM URIC ACID LEVEL IN PATIENTS WITH IMPAIRED GLUCOSE TOLERANCE AS COMPARED TO SUBJECTS WITH NORMAL GLUCOSE TOLERANCE

Pakistan Armed Forces Medical Journal, 2019
Objective: To determine serum uric acid level in patients with impaired glucose tolerance as compared to subjects with normal glucose tolerance. Study Design: Case control study.
Muhammad Zubair, Majida Farooq, Muhammad Rafi Butt, Muhammad Farooq, Sajida Shaheen, Sahar Rabbani   +5 more
doaj  

Relationship between BMI and risk of impaired glucose tolerance and impaired fasting glucose in Chinese adults: a prospective study

BMC Public Health, 2023
Background Current studies in most Western countries have largely focused on body mass index (BMI) as an important risk factor for impaired glucose tolerance (IGT) and impaired fasting glucose (IFG), which have different pathophysiological bases.
Xin Zhang, Yankun Yue, Shaobo Liu, Xiangfeng Cong, Wenjuan Wang, Jianhong Li   +5 more
doaj   +1 more source

Microneedle Technology in Psoriasis Management: Mechanistic Insights, Technological Innovation, Clinical Progress, and Challenges

Advanced Healthcare Materials, EarlyView.
This review explores the evolving role of microneedle systems in psoriasis management, highlighting their potential for enhanced drug delivery, diagnosis, and disease monitoring. It also discusses unmet clinical needs for psoriasis management and technical challenges, while outlining strategic directions to advance microneedle integration into routine ...
Fatma Moawad, Yasmine Ruel, Roxane Pouliot, Davide Brambilla   +3 more
wiley   +1 more source

How can we keep impaired glucose tolerance and impaired fasting glucose from progressing to diabetes? [PDF]

, 2010
Lifestyle interventions aimed at weight loss of 5% to 10% of body weight along with moderate aerobic exercise such as brisk walking for 150 minutes a week are the most effective means to prevent impaired fasting glucose (IFG) or impaired glucose ...
Swanson, Ana, Watrin, Kerry, Wilder, Laura   +2 more
core  

Evidence of a metabolic memory to early-life dietary restriction in male C57BL/6 mice [PDF]

, 2012
<p>Background: Dietary restriction (DR) extends lifespan and induces beneficial metabolic effects in many animals. What is far less clear is whether animals retain a metabolic memory to previous DR exposure, that is, can early-life DR preserve ...
A Ceriello, A Dubey, A Nakamura, A Taguchi, BJ Merry, BJ Merry, BP Yu, BS Hass, C Hambly, C Messier, C Selman, C Selman, CK Lee, CK Lee, DP Argentino, EP Weiss, F Capstick, H Maeda, J Cantley, J Jacobson, JD Mulligan, JF Clinthorne, JM Dhahbi, JM Dhahbi, JR Mitchell, JR Speakman, L Fontana, LK Heilbronn, LM Redman, MJ Forster, MJ Forster, R Weindruch, R Weindruch, RJ Colman, RM Anson, S Goto, S Hempenstall, S Keipert, S Park, S Rezzi, SK Barnes, SL Johnston, SS Jessani, SX Cao, TM Wallace, W Mair, X Li   +46 more
core   +1 more source

Biofabrication of Endothelialized, Intrinsically Vascularized 3D‐Printed Recombinant Spider Silk Scaffolds

Advanced Healthcare Materials, EarlyView.
This study evaluates 3D‐printed recombinant spider silk hydrogel eADF4(C16)‐RGD in a rat AV loop model for tissue engineering. Constructs with T17b endothelial progenitor cells showed enhanced vascularization and biodegradation. Results highlight the importance of scaffold design and cellular integration in improving vascular density and overall ...
Claire M. Weinhold, Stefanie Heltmann‐Meyer, Xuen J. Ng, Thomas Scheibel, Tobias Fey, Harald Wajant, Carol Geppert, Andreas Arkudas, Dominik Steiner, Raymund E. Horch   +9 more
wiley   +1 more source

Prevalence of diabetes mellitus and impaired glucose tolerance in the urban population aged 30-69 years in Ribeirão Preto (São Paulo), Brazil

São Paulo Medical Journal
CONTEXT: Diabetes mellitus prevalence has been increasing worldwide due to factors like lifestyle changes and higher life expectancy. The Brazilian Multicenter Study performed between 1986 and 1988 evaluated the prevalence of diabetes and impaired ...
Maria Teresa da Costa Gonçalves Torquato, Renan Magalhães Montenegro Junior, Luis Atílio Losi Viana, Rui Augusto Hudari Gonçalves de Souza, Carla Márcia Moreira Lanna, Júlio César Batista Lucas, Cláudio Bidurin, Milton Cesar Foss   +7 more
doaj   +1 more source