Results 71 to 80 of about 99,909 (304)
DNA repair and the contribution to chemotherapy resistance
Genome MedicineThe DNA damage response comprises a set of imperfect pathways that maintain cell survival following exposure to DNA damaging agents. Cancers frequently exhibit DNA repair pathway alterations that contribute to their intrinsic genome instability. This, in
Ksenija Nesic +3 more
doaj +1 more source
Salvaging External Iliac Artery Dissection during Renal Transplant: A Case Series
Indian Journal of TransplantationExternal iliac artery dissection is a rare and reversible but serious complication of renal transplant that may ultimately lead to loss of kidney and lower limb.
Neethu Varghese +2 more
doaj +1 more source
AAV-Mediated CRISPR/Cas9 Gene Editing in Murine Phenylketonuria
Molecular Therapy: Methods & Clinical Development, 2020 Phenylketonuria (PKU) due to recessively inherited phenylalanine hydroxylase (PAH) deficiency results in hyperphenylalaninemia, which is toxic to the central nervous system. Restriction of dietary phenylalanine intake remains the standard of PKU care and
Daelyn Y. Richards +6 more
doaj +1 more source
Overview of molecular signatures of senescence and associated resources: pros and cons
FEBS Open Bio, EarlyView.Cells can enter a stress response state termed cellular senescence that is involved in various diseases and aging. Detecting these cells is challenging due to the lack of universal biomarkers. This review presents the current state of senescence identification, from biomarkers to molecular signatures, compares tools and approaches, and highlights ...
Orestis A. Ntintas +6 more
wiley +1 more source
Проблеми енергозбереження при транспортуванні газу і подачі його споживачам [PDF]
, 2007 Основное внимание уделено особенностям ремонта дефектных участков магистральных газопроводов без их остановки. При этом учтена форма тела трубы для монтажа усиливающих бандажей, дефектных стыков для монтажа двухслойных усиливающих герметических муфт ...
Гулька, П. П.
core
The role of lipid metabolism in neuronal senescence
FEBS Open Bio, EarlyView.Disrupted lipid metabolism, through alterations in lipid species or lipid droplet accumulation, can drive neuronal senescence. However, lipid dyshomeostasis can also occur alongside neuronal senescence, further amplifying tissue damage. Delineating how lipid‐induced senescence emerges in neurons and glial cells, and how it contributes to ageing and ...
Dikaia Tsagkari +2 more
wiley +1 more source
Emerging Pronoun Practices After the Procedural Turn: Disclosure, Discovery, and Repair
Sociological ScienceWe examine emerging practices of pronoun disclosure, discovery, and repair after the procedural turn in pronoun politics, which shifted attention from the substantive question of which pronouns should be used to the procedural question of how preferred ...
Julieta Goldenberg, Rogers Brubaker
doaj +1 more source
FEBS Open Bio, EarlyView.Mouse pre‐implantation development involves a transition from totipotency to pluripotency. Integrating transcriptomics, epigenetic profiling, low‐input proteomics and functional assays, we show that eight‐cell embryos retain residual totipotency features, whereas cytoskeletal remodeling regulated by the ubiquitin‐proteasome system drives progression ...
Wanqiong Li +8 more
wiley +1 more source
On the Statistical Modeling and Analysis of Repairable Systems
, 2007 We review basic modeling approaches for failure and maintenance data from repairable systems. In particular we consider imperfect repair models, defined in terms of virtual age processes, and the trend-renewal process which extends the nonhomogeneous ...
Lindqvist, Bo Henry
core +1 more source
Impact of template backbone heterogeneity on RNA polymerase II transcription. [PDF]
, 2014 Variations in the sugar component (ribose or deoxyribose) and the nature of the phosphodiester linkage (3'-5' or 2'-5' orientation) have been a challenge for genetic information transfer from the very beginning of evolution.
Chong, Jenny +5 more
core +1 more source