Results 71 to 80 of about 2,616,415 (296)

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Moving beyond Aim Three: a need for a transdisciplinary approach to build capacity for economic evaluations in implementation science

Implementation Science Communications, 2021
Background Understanding the costs and economic benefits of implementation has been identified by policymakers and researchers as critical to increase the uptake and sustainment of evidence-based practices, but this topic remains relatively understudied.
Miya L. Barnett, Nicole A. Stadnick, Enola K. Proctor, Alex R. Dopp, Lisa Saldana   +4 more
doaj   +1 more source

Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer

FEBS Letters, EarlyView.
Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani, Noemi E. Nwosu, Viktoria Gocke, Müge Kasanmascheff, Hannes Mutschler   +4 more
wiley   +1 more source

PENERAPAN AGRARISCHE WET (UNDANG-UNDANG AGRAIA) 1870: PERIODE AWAL SWASTANISASI PERKEBUNAN DI PULAU JAWA

Historia: Jurnal Pendidikan Sejarah FKIP UM Metro, 2020
The development of plantations in Indonesia is divided into two phases. The first phase is called the state plantation phase (1830-1870). Meanwhile, the second phase is the private plantation phase, the phase after the implementation of the Wet ...
M Masyrullahushomad, S Sudrajat
doaj   +1 more source

Monolithic simulation of convection-coupled phase-change - verification and reproducibility

, 2018
Phase interfaces in melting and solidification processes are strongly affected by the presence of convection in the liquid. One way of modeling their transient evolution is to couple an incompressible flow model to an energy balance in enthalpy ...
C Boettiger, DW Kelly, F Brezzi, GK Batchelor, HW Hsu, I Danaila, J Donea, J Kowalski, MS Dinniman, S Wang, UKNG Ghia, V Alexiades, VR Voller, VR Voller, W Bangerth, Y Belhamadia, Y Dutil   +16 more
core   +1 more source

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

Compatibility Implementation Plan for Xi’an Metro Line 2 Phase Ⅰ and Phase Ⅱ Project Signaling Systems

Chengshi guidao jiaotong yanjiu
[Objective] The signaling system for Xi’an Metro Line 2 Phase Ⅰ project (hereinafter referred to as Line 2) utilizes an imported system, while Phase Ⅱ adopts a domestically developed system.
SUN Hui, REN Yaping, LIANG Bo
doaj   +1 more source

The Impact of a Digital Speaker on a Teacher's Interaction with a Child with Limited Functional Speech

South African Journal of Communication Disorders, 1999
This paper describes the impact of the implementation of a digital speaker and teacher training on the quality of a teacher's interaction with an AAC user. The data was obtained by recording and analysing classroom story time interactions.
Elsa Popich, Erna Alant
doaj   +1 more source

Characterizing the salivary RNA landscape to identify potential diagnostic, prognostic, and follow‐up biomarkers for breast cancer

Molecular Oncology, EarlyView.
This study explores salivary RNA for breast cancer (BC) diagnosis, prognosis, and follow‐up. High‐throughput RNA sequencing identified distinct salivary RNA signatures, including novel transcripts, that differentiate BC from healthy controls, characterize histological and molecular subtypes, and indicate lymph node involvement.
Nicholas Rajan, Irina Primac, Emre Etlioglu, Laurens Debruyne, Ann Janssen, Magy Sallam, Kevin Tabury, Roel Quintens, Wiebren Tjalma, Mohammed Abderrafi Benotmane   +9 more
wiley   +1 more source

Bridging the gap: Multi‐stakeholder perspectives of molecular diagnostics in oncology

Molecular Oncology, EarlyView.
Although molecular diagnostics is transforming cancer care, implementing novel technologies remains challenging. This study identifies unmet needs and technology requirements through a two‐step stakeholder involvement. Liquid biopsies for monitoring applications and predictive biomarker testing emerge as key unmet needs. Technology requirements vary by
Jorine Arnouts, Senada Koljenović, Elise Daems, Karolien De Wael, Marc Peeters, Léon C. van Kempen, Greetje Vanhoutte, Karen Zwaenepoel, Timon Vandamme   +8 more
wiley   +1 more source