Results 51 to 60 of about 419,250 (318)

Permutation importance: a corrected feature importance measure [PDF]

Bioinformatics, 2010
Abstract Motivation: In life sciences, interpretability of machine learning models is as important as their prediction accuracy. Linear models are probably the most frequently used methods for assessing feature relevance, despite their relative inflexibility.
André Altmann, Laura Tolosi, Oliver Sander, Thomas Lengauer   +3 more
openaire   +3 more sources

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Ebola Virus Imported from Guinea to Senegal, 2014

Emerging Infectious Diseases, 2017
In March 2014, the World Health Organization declared an outbreak of Ebola virus disease in Guinea. In August 2014, a case caused by virus imported from Guinea occurred in Senegal, most likely resulting from nonsecure funerals and travel.
Daye Ka, Gamou Fall, Viviane Cissé Diallo, Ousmane Faye, Louise Deguenonvo Fortes, Oumar Faye, Elhadji Ibrahim Bah, Kadia Mbaye Diallo, Fanny Balique, Cheikh Tidiane Ndour, Moussa Seydi, Amadou Alpha Sall   +11 more
doaj   +1 more source

YlmG1 is localized exclusively to the chloroplast envelope membrane and is involved in preprotein translocation in Arabidopsis thaliana

FEBS Open Bio, EarlyView.
Cytosolically synthesized chloroplast preproteins are translocated across the outer and inner envelope membranes through translocons called TOC and TIC, respectively. In green algae and plants, the TIC core is composed of essential membrane proteins, Tic12, Tic20, and Tic214.
Mengyi Li, Xueyang Zhao, Masato Nakai
wiley   +1 more source

Delayed diagnosis of parapoxvirus infections and a review of pox infections other than mpox in the United Kingdom

Clinical Infection in Practice
Background: Orf virus is a member of the genus parapoxvirus. Orf is an infection of sheep and goats but humans can become infected after direct contact with an infected mammal.
Ameeka Thompson, Aysha Jameel, Christina Petridou, N Claire Gordon   +3 more
doaj   +1 more source

Anaplasmataceae-Specific PCR for Diagnosis and Therapeutic Guidance for Symptomatic Neoehrlichiosis in Immunocompetent Host

Emerging Infectious Diseases, 2016
Candidatus Neoehrlichia is increasingly being recognized worldwide as a tickborne pathogen. We report a case of symptomatic neoehrlichiosis in an immunocompetent Austria resident who had recently returned from travel in Tanzania.
Michael Schwameis, Julia Auer, Dieter Mitteregger, Ingrid Simonitsch-Klupp, Michael Ramharter, Heinz Burgmann, Heimo Lagler   +6 more
doaj   +1 more source

Iron homeostasis disruption and lipid peroxidation in skeletal muscle during short‐term immobilization

FEBS Open Bio, EarlyView.
14‐day casting‐induced immobilization reduced gastrocnemius muscle mass and increased non‐heme iron and ferritin heavy chain levels. Despite iron accumulation, transferrin receptor 1 and iron regulatory protein 2 were paradoxically upregulated. Lipid peroxidation was elevated without compensatory antioxidant responses.
Haruka Yokogawa, Kazuhiko Higashida, Naoya Nakai   +2 more
wiley   +1 more source

Importance tempering

Statistics and Computing, 2008
16 pages, 2 tables, significantly shortened from version 4 in response to referee comments, to appear in Statistics and ...
Robert B. Gramacy, Richard Samworth, Ruth King   +2 more
openaire   +2 more sources

Proteasomal degradation of intracellularly expressed Amblyomin‐X limits suicide gene therapy potential in melanoma cells

FEBS Open Bio, EarlyView.
This study explores the feasibility of expressing the antitumoral protein Amblyomin‐X through a suicide gene therapy approach and investigates its intracellular fate after gene delivery. Although the gene is efficiently expressed, melanoma cells rapidly degrade the Amblyomin‐X protein via proteasome activity.
Victor Dal Posolo Cinel, Carlos DeOcesano Pereira, Aline Ramos Maia Lobba, Melissa Regina Fessel, Ana Marisa Chudzinski‐Tavassi   +4 more
wiley   +1 more source

Malaria in Nonimmune Travelers [PDF]

, 1994
Background: With the current increase of international travel to tropical endemic areas, the incidence of malaria being imported into nonendemic countries has increased significantly.
Nothdurft, H. D., Tomas Jelinek, H. D. Nothdurft, Jelinek, Thomas, T. Loscher, Löscher, Thomas   +5 more
core   +1 more source