Results 131 to 140 of about 137,611 (281)
Advanced Science, EarlyView.Cysteine‐engineered mini‐spidroins (∼33 kDa) undergo phosphate‐induced liquid–liquid phase separation (LLPS), where disulfide bonds lock partially aligned polyA segments. Subsequent microfluidic spinning promotes directional β‐sheet crystallization, producing fibers with 531 MPa strength and 182 MJ/m3 toughness.
Min Li +10 more
wiley +1 more source
NanoLoop: A Deep Learning Framework Leveraging Nanopore Sequencing for Chromatin Loop Prediction
Advanced Science, EarlyView.Chromatin loops are central to gene regulation and 3D genome organization. Leveraging Nanopore sequencing's ability to jointly capture DNA sequence and methylation, we present NanoLoop, the first framework for genome‐wide chromatin loop prediction using Nanopore data.
Wenjie Huang +5 more
wiley +1 more source
Advanced Science, EarlyView.Senescent synovial intimal fibroblasts (SIF) are identified as key drivers of osteoarthritis. They promote M1 macrophage polarization and cartilage degeneration via the ANGPTL4–α5β1 axis, regulated by transcription factors EGR1 and ATF3. Pharmacological inhibition of this pathway alleviates disease, revealing SIF senescence as a promising therapeutic ...
Muhai Deng +7 more
wiley +1 more source
Advanced Science, EarlyView.Machine learning‐assisted surface‐enhanced Raman spectroscopy analysis of exosomal sialic acid for ovarian cancer diagnosis, as well as independent monitoring of exosomal sialic acid expression levels across different treatment periods, reveals a potential correlation with treatment response.
Lili Cong +6 more
wiley +1 more source
Novel Strategies for Developing Next-Generation Vaccines to Combat Infectious Viral Diseases
VaccinesThe development of viral vaccines faces persistent scientific and logistical challenges, particularly in the wake of the COVID-19 pandemic. This review critically examines emerging strategies to overcome key barriers in viral vaccine design and ...
Fangfeng Yuan, Martin H. Bluth
doaj +1 more source
Nanozymes Integrated Biochips Toward Smart Detection System
Advanced Science, EarlyView.This review systematically outlines the integration of nanozymes, biochips, and artificial intelligence (AI) for intelligent biosensing. It details how their convergence enhances signal amplification, enables portable detection, and improves data interpretation.
Dongyu Chen +10 more
wiley +1 more source
Advanced Science, EarlyView.Mitochondria‐targeted silver single‐atom carbon dot (T‐AgSA‐CDs) nanozymes enable dual SOD/GPx‐like ROS scavenging, real‐time imaging, and therapeutic effects for acute kidney injury (AKI). Atomically dispersed Ag sites synergize with carbon dots to restore renal redox hemostasis, protect mitochondrial function, mitigate inflammation, facilitate post ...
Tianle Tang +10 more
wiley +1 more source
A Study on the Appearance and Behavioral Patterns of Robots for Fostering Attachment in Users
Applied SciencesAs the importance of emotional interaction between humans and robots continues to gain attention, numerous studies have been conducted to identify the characteristics and effects of emotional HRI (Human–Robot Interaction) elements applied to robots ...
Younseal Eum +4 more
doaj +1 more source
Advanced Science, EarlyView.A humidity‐tolerant triboelectric nanogenerator is developed using conductive carbon black‐modified silicone rubber and a flame‐retardant gas barrier layer. The device efficiently harvests footstep energy while maintaining stable output under 30–90% RH and over 1 million cycles.
Yi Wei +7 more
wiley +1 more source