Association of four imprinting disorders and ART [PDF]
Clinical Epigenetics, 2019 Background Human-assisted reproductive technologies (ART) are a widely accepted treatment for infertile couples. At the same time, many studies have suggested the correlation between ART and increased incidences of normally rare imprinting disorders such
Hiromitsu Hattori +10 more
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The Role of Long Non-coding RNAs in Human Imprinting Disorders: Prospective Therapeutic Targets [PDF]
Frontiers in Cell and Developmental Biology, 2021 Genomic imprinting is a term used for an intergenerational epigenetic inheritance and involves a subset of genes expressed in a parent-of-origin-dependent way.
Tingxuan Wang +4 more
doaj +3 more sources
Novel epigenetic molecular therapies for imprinting disorders. [PDF]
Mol Psychiatry, 2023 Genomic imprinting disorders are caused by the disruption of genomic imprinting processes leading to a deficit or increase of an active allele. Their unique molecular mechanisms underlying imprinted genes offer an opportunity to investigate epigenetic ...
Wang SE, Jiang YH.
europepmc +4 more sources
Association of Assisted Reproductive Technology Treatments with Imprinting Disorders [PDF]
Global Medical Genetics, 2021 Assisted reproductive technology (ART) is a broad field in infertility that encompasses different types of treatments. These revolutionary treatment methods aimed to aid infertile or subfertile couples. Treatment was expanded exponentially, as 1 to 3% of
T. Kopca, Pinar Tulay
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Promising therapeutic aspects in human genetic imprinting disorders. [PDF]
Clin Epigenetics, 2022 Genomic imprinting is an epigenetic phenomenon of monoallelic gene expression pattern depending on parental origin. In humans, congenital imprinting disruptions resulting from genetic or epigenetic mechanisms can cause a group of diseases known as ...
Chao Y +6 more
europepmc +4 more sources
Chromosome 15 Imprinting Disorders: Genetic Laboratory Methodology and Approaches [PDF]
Frontiers in Pediatrics, 2020 Chromosome 15 imprinting disorders include Prader-Willi (PWS) and Angelman (AS) syndromes, which are caused by absent expression from the paternal and maternal alleles in the chromosome 15q11. 2–q13 region, respectively.
Merlin G. Butler, Jessica Duis
doaj +3 more sources
The origin of imprinting defects in Temple syndrome and comparison with other imprinting disorders [PDF]
Epigenetics, 2018 Temple syndrome (TS14) is a rare imprinting disorder caused by genetic and epigenetic alterations on chromosome 14q32. A subset of these patients shows an imprinting defect (ID) where the paternal allele harbors a maternal epigenotype thus silencing the ...
Jasmin Beygo +6 more
doaj +3 more sources
Characterization of multi-locus imprinting disturbances and underlying genetic defects in patients with chromosome 11p15.5 related imprinting disorders [PDF]
Epigenetics, 2018 The identification of multilocus imprinting disturbances (MLID) appears fundamental to uncover molecular pathways underlying imprinting disorders (IDs) and to complete clinical diagnosis of patients.
L. Fontana +16 more
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First step towards a consensus strategy for multi-locus diagnostic testing of imprinting disorders. [PDF]
Clin Epigenetics, 2022 Background Imprinting disorders, which affect growth, development, metabolism and neoplasia risk, are caused by genetic or epigenetic changes to genes that are expressed from only one parental allele.
Mackay D +28 more
europepmc +2 more sources
Epigenetic Mechanisms of ART-Related Imprinting Disorders: Lessons From iPSC and Mouse Models. [PDF]
Genes (Basel), 2021 The rising frequency of ART-conceived births is accompanied by the need for an improved understanding of the implications of ART on gametes and embryos. Increasing evidence from mouse models and human epidemiological data suggests that ART procedures may
Horánszky A +4 more
europepmc +2 more sources