Results 11 to 20 of about 1,300,694 (272)

Multilocus methylation defects in imprinting disorders

Biomolecular Concepts, 2015
Mammals inherit two complete sets of chromosomes, one from the father and one from the mother, and most autosomal genes are expressed from both maternal and paternal alleles. In imprinted genes, the expression of the allele is dependent upon its parental
Mackay Deborah J.G., Eggermann Thomas, Buiting Karin, Garin Intza, Netchine Irène, Linglart Agnès, de Nanclares Guiomar Perez   +6 more
doaj   +6 more sources

Role of ART in Imprinting Disorders [PDF]

Seminars in Reproductive Medicine, 2012
Assisted reproductive technologies (ART) offer revolutionary infertility treatments for millions of childless couples around the world. Currently, ART accounts for 1 to 3% of annual births in industrialized countries and continues to expand rapidly. Except for an increased incidence of premature births, these technologies are considered safe.
Lawrence Layman, Ali Eroğlu
exaly   +5 more sources

The impact of assisted reproductive technologies on genomic imprinting and imprinting disorders [PDF]

Current Opinion in Obstetrics & Gynecology, 2014
Uyar, Asli/0000-0002-7913-1083Purpose of reviewGenomic imprinting refers to preferential allele-specific gene expression. DNA methylation-based molecular mechanisms regulate establishment and maintenance of parental imprints during early embryo ...
Uyar, Asli, Seli, Emre
core   +3 more sources

Recent Advances in Imprinting Disorders

NeoReviews, 2017
Genetic imprinting is a biological phenomenon arising from the fact that maternal and paternal contributions to the offspring’s autosomal genes have specific markers or imprints.
Naveed Hussain
core   +2 more sources

Disturbed methylation at multiple imprinted loci : an increasing observation in imprinting disorders

Epigenomics, 2011
The widely accepted association between aberrant methylation at specific imprinted loci and distinct imprinting disorders has recently been brought into question by the identification of methylation defects at multiple loci (multilocus methylation ...
Thomas Eggermann, Eggermann, Thomas, Matthias Begemann, Gerhard Binder, Leisten, Isabelle, Spengler, Sabine, Begemann, Matthias, Isabelle Leisten, Binder, Gerhard, Sabrina Spengler   +9 more
core   +3 more sources

Imprinting disorders in humans: a review. [PDF]

Curr Opin Pediatr, 2020
Purpose of review Mammals have two complete sets of chromosomes, one from each parent with equal autosomal gene expression. Less than one percentage of human genes are imprinted or show expression from only one parent without changing gene structure, usually by DNA methylation, but reversible in gametogenesis.
Butler MG.
europepmc   +4 more sources

Mechanisms controlling genomic imprinting and their dysregulation in human imprinting disorders

Annales d'Endocrinologie
International audienceImprinted genes play a pivotal role in regulating growth, development, and behavior through parent-of-originspecific expression. This allelic specificity is orchestrated by "imprinting control regions" (ICRs), which depend on DNA ...
Court, Franck, Juven, Aurélien, Arnaud, Philippe, P., Vaurs-Barrière, Catherine, Montibus, Bertille   +4 more
core   +3 more sources

First step towards a consensus strategy for multi-locus diagnostic testing of imprinting disorders. [PDF]

Clin Epigenetics, 2022
BACKGROUND: Imprinting disorders, which affect growth, development, metabolism and neoplasia risk, are caused by genetic or epigenetic changes to genes that are expressed from only one parental allele. Disease may result from changes in coding sequences,
Mackay D, Bliek J, Kagami M, Tenorio-Castano J, Pereda A, Brioude F, Netchine I, Papingi D, de Franco E, Lever M, Sillibourne J, Lombardi P, Gaston V, Tauber M, Diene G, Bieth E, Fernandez L, Nevado J, Tümer Z, Riccio A, Maher ER, Beygo J, Tannorella P, Russo S, de Nanclares GP, Temple IK, Ogata T, Lapunzina P, Eggermann T.   +28 more
europepmc   +5 more sources

Culture-dependent decoupling of H19 allele-specific expression from H19/IGF2:IG-DMR methylation in experimental models [PDF]

Epigenetics
Genomic imprinting is an epigenetic mechanism leading to the monoallelic expression of a subset of genes, mainly regulated by DNA methylation at imprinting control regions (ICRs).
Céline Selenou, Frédéric Brioude, Laure Sudre, Aurélie Pham, Irène Netchine, Marie-Laure Sobrier, Éloïse Giabicani   +6 more
doaj   +2 more sources

Novel epigenetic molecular therapies for imprinting disorders. [PDF]

Mol Psychiatry, 2023
AbstractGenomic imprinting disorders are caused by the disruption of genomic imprinting processes leading to a deficit or increase of an active allele. Their unique molecular mechanisms underlying imprinted genes offer an opportunity to investigate epigenetic-based therapy for reactivation of an inactive allele or reduction of an active allele. Current
Wang SE, Jiang YH.
europepmc   +3 more sources