Results 61 to 70 of about 475,711 (295)
FEBS Open Bio, EarlyView.A regulatory axis involving APE1, AUF1, and miR‐221 is proposed. Pri‐miR‐221 is processed by DROSHA and DICER to generate mature miR‐221, which targets p27Kip1 mRNA. APE1 and AUF1 compete for pre‐miR‐221 binding. Reduced APE1/AUF1 levels impair miR‐221 biogenesis, decrease p27Kip1 mRNA degradation, and promote cell cycle progression, chemoresistance ...
Matilde Clarissa Malfatti +3 more
wiley +1 more source
Nature CommunicationsRapid movements of plant structures triggered by mechanical force have been documented for centuries; however, how plant cells sense mechanical stimuli and generate rapid response remains unknown.
Xuan Zhou +8 more
doaj +1 more source
FEBS Open Bio, EarlyView.Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero +5 more
wiley +1 more source
The importance of keeping in touch: regulation of cell-cell contact in the exocrine pancreas [PDF]
Gut, 2005 New insights into the mechanisms regulating acinar cell-cell contact in the exocrine pancreas, with evidence to support a role for PTPκ as a key molecule in stabilisation of the adhesion complex in acinar cells via continuous dephosphorylation of the cadherin-catenin complex The formation of tissues and organs of multicellular organisms during ...
M V, Apte, J S, Wilson
openaire +2 more sources
Remote Assessment of Ataxia Severity in SCA3 Across Multiple Centers and Time Points
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Spinocerebellar ataxia type 3 (SCA3) is a genetically defined ataxia. The Scale for Assessment and Rating of Ataxia (SARA) is a clinician‐reported outcome that measures ataxia severity at a single time point. In its standard application, SARA fails to capture short‐term fluctuations, limiting its sensitivity in trials.
Marcus Grobe‐Einsler +20 more
wiley +1 more source
Touch Receptors Undergo Rapid Remodeling in Healthy Skin
Cell Reports, 2016 Sensory tissues exposed to the environment, such as skin, olfactory epithelia, and taste buds, continuously renew; therefore, peripheral neurons must have mechanisms to maintain appropriate innervation patterns.
Kara L. Marshall +5 more
doaj +1 more source
, 2018 Plants can sense both intracellular and extracellular mechanical forces and can respond through morphological changes. The signaling components responsible for mechanotransduction of the touch response are largely unknown.
Braam, Janet +12 more
core +2 more sources
Arthritis Care &Research, EarlyView.Objective Sjögren's disease is an autoimmune disorder that can impact multiple organ systems, including the peripheral nervous system (PNS). PNS manifestations, which can exist concurrently, include mononeuropathies, polyneuropathies, and autonomic nervous system neuropathies.
Anahita Deboo +88 more
wiley +1 more source
Cell Reports, 2014 Mechanoelectrical transduction (MeT) channels embedded in neuronal cell membranes are essential for touch and proprioception. Little is understood about the interplay between native MeT channels and membrane phospholipids, in part because few techniques ...
Valeria Vásquez +3 more
doaj +1 more source
A patient with giant squamous cell carcinoma arising from hidradenitis suppurativa
Pifu-xingbing zhenliaoxue zazhi, 2022 We report a giant squamous cell carcinoma arising from hidradenitis suppurativa. A 62-year-old man presented with ulceration and painful nodule on the left side of the buttock for over 40 years, and a neoplastic mass for more than 20 years ...
Rong ZHOU +3 more
doaj +1 more source