Results 91 to 100 of about 2,073,746 (211)

Structure‐forward targeting of claudins with synthetic binders

open access: yesFEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

THE ROLE OF FINANCIAL PERFORMANCE IN DIFFERENCE OF TWO MANUFACTURER’S BRAND VALUE

open access: yesAnnals of the University of Oradea: Economic Science
Brands are becoming more and more important for enterprises that spend significant amounts on building strong ones. Howewer, the value of brands and the way it should be represented in financial reports is still controversial. Our general objective is to
Alexandra SZEKERES   +2 more
doaj   +1 more source

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

open access: yesFEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas   +4 more
wiley   +1 more source

Rethinking Authority, Creativity and Authorship in Twenty-First-Century Performance: The Director’s Revised Role

open access: yesCritical Stages, 2020
The conversation about the director’s changing identity, as our century gallops towards or stumbles through challenges that few could have anticipated even a few years—let alone months—ago is becoming all the more complex.
Avra Sidiropoulou
doaj  

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

open access: yesFEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt   +8 more
wiley   +1 more source

The role of interviews in predicting student OSCE performance: medical students’ perspective

open access: yesAdvances in Medical Education and Practice, 2018
Mohammed Abdul Shafi, Mohamed Rimzy Mohamed Riza, Muhammed Shaan RiazFaculty of Medicine, St George’s Hospital Medical School, London, UKWe have read with great interest the article by Kumar et al,1 which correlates the performance of physician ...
Shafi MA, Mohamed Riza MR, Riaz MS
doaj  

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

open access: yesFEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang   +2 more
wiley   +1 more source

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