Results 121 to 130 of about 497,128 (308)

A comparative in-silico analysis of autophagy proteins in ciliates

PeerJ, 2017
Autophagy serves as a turnover mechanism for the recycling of redundant and/or damaged macromolecules present in eukaryotic cells to re-use them under starvation conditions via a double-membrane structure known as autophagosome. A set of eukaryotic genes called autophagy-related genes ( ATG s)
Aslan, Erhan, Küçükoğlu, Nurçin, Arslanyolu, Muhittin   +2 more
openaire   +3 more sources

Understanding the Effects of Conductive Polymer Electrode Coating on Recorded Neural Signals

Advanced Healthcare Materials, EarlyView.
Conductive polymer coatings are widely explored to improve the quality of signals recorded with chronically implanted neural electrodes, offering enhanced biocompatibility along with reduced electrode impedance. Combining computational modelling and data from PEDOT:PTS coated and PtIr electrodes in rats, we show that improvements in signal quality with
Karthik Sridhar, Judith Evers, Alexandre Trotier, Manus Biggs, Madeleine M. Lowery   +4 more
wiley   +1 more source

Optimizing human pulmonary perfusion measurement using an in silico model of arterial spin labeling magnetic resonance imaging. [PDF]

, 2019
Arterial spin labeling (ASL) magnetic resonance imaging (MRI) is an imaging methodology that uses blood as an endogenous contrast agent to quantify flow.
Addo, Daniel A, Burrowes, Kelly Suzzane, Kang, Wendy, Prisk, Gordon Kim, Tawhai, Merryn H   +4 more
core   +1 more source

Dual‐Peptide Nanoplatform: Mesoporous Silica Nanoparticles Functionalized With a Cell‐Penetrating Peptide and Loaded With Rationally Designed Antimicrobial Peptides for Tuberculosis Therapy

Advanced Healthcare Materials, EarlyView.
Machine learning–guided engineering of a plectasin‐derived peptide yields DC05, a potent antimycobacterial candidate. Encapsulation into tuftsin‐functionalized mesoporous silica nanoparticles enhances intracellular delivery, stability, and activity against Mycobacterium tuberculosis while maintaining low cytotoxicity and minimal hemolysis. The combined
Christian S. Carnero Canales, Cesar Augusto Roque‐Borda, Ana Carolina Cerqueira Negri, Oswaldo Ramirez Delgado, Letícia Oliveira Catarin Nunes, Flávia Aparecida Resende, Hernane Barud, Norival Alves Santos‐Filho, Saulo Santesso Garrido, Karen Cristina Oliveira, Alexandra Ivo de Medeiros, Rafael Miguel Sábio, Fernando Rogério Pavan   +12 more
wiley   +1 more source

Deciphering the Role of Cancer Stem Cells in Breast Cancer Brain Colonization Using a Novel Patient‐Derived Model

Advanced Healthcare Materials, EarlyView.
This study shows that stem‐like cells isolated from breast cancer brain metastases drive the spread and growth of tumors in the brain. Among them, a highly adhesive subgroup initiates metastasis and resists many drugs. By closely reflecting patient tumors, these models help identify new targets and improve the development of effective treatments ...
Stefania Faletti, Cristina Richichi, Daniela Osti, Elena Ceccacci, Giovanni Bertalot, Camilla Cerutti, Giuseppina Giardina, Adriana Marinaro, Brunella Costanza, Valentina Gambino, Elena Zaccheroni, Daniela Tosoni, Maria G. Filippone, Marcello Del Corvo, Yinxiu Zhan, Teresa Gravina, Davide Corà, Monica Patanè, Bianca Pollo, Maria Giovanna Jodice, Salvatore Pece, Babette B. Weksler, Ignacio A. Romero, Pierre‐Olivier Couraud, Elisabetta Munzone, Massimiliano Del Bene, Francesco DiMeco, Giuliana Pelicci   +27 more
wiley   +1 more source

In silico study of Bacillus spB201 amylase through protein sequence inspection

Journal of the Arab Society for Medical Research
Background/aim Bioinformatics is the automatic processing of biological information, and it is a helpful tool to study the structure-function relationship of various proteins.
Sameh Ben Mabrouk, Bouthaina Ben Hadj Hmida, Ikram Boukthir, Slim Cherif   +3 more
doaj   +1 more source

In silico characterization of boron transporter (BOR1) protein sequences in Poaceae species [PDF]

Journal of BioScience and Biotechnology, 2013
Boron (B) is essential for the plant growth and development, and its primary function is connected with formation of the cell wall. Moreover, boron toxicity is a shared problem in semiarid and arid regions. In this study, boron transporter protein (BOR1)
Ertuğrul Filiz
doaj  

APOBEC-related mutagenesis and neo-peptide hydrophobicity: implications for response to immunotherapy. [PDF]

, 2019
Tumor-associated neo-antigens are mutated peptides that allow the immune system to recognize the affected cell as foreign. Cells carrying excessive mutation load often develop mechanisms of tolerance.
Boichard, Amélie, Frampton, Garrett M, Goodman, Aaron, Kurzrock, Razelle, Lippman, Scott, Pham, Timothy V, Tamayo, Pablo, Tsigelny, Igor F, Yeerna, Huwate   +8 more
core  

Rapid Sequence Identification of Potential Pathogens Using Techniques from Sparse Linear Algebra

, 2015
The decreasing costs and increasing speed and accuracy of DNA sample collection, preparation, and sequencing has rapidly produced an enormous volume of genetic data. However, fast and accurate analysis of the samples remains a bottleneck. Here we present
Chiu, Nelson, Dodson, Stephanie, Kepner, Jeremy, Ricke, Darrell O., Shcherbina, Anna   +4 more
core   +1 more source

Model‐Driven Optimization of Subcutaneous Polymer Prodrugs Achieves Cancer Remission in Mice

Advanced Healthcare Materials, EarlyView.
A pharmacokinetics/pharmacodynamics (PK/PD) model was developed to evaluate multiple dosing regimens for subcutaneously administered water‐soluble polymer prodrug for cancer therapy. The model enabled prediction of in vivo performance and contributed to the optimization of anticancer efficacy.
Anne Rodallec, Randy Lee, Jingming Cao, Sophie Marolleau, Julien Nicolas, Sébastien Benzekry   +5 more
wiley   +1 more source