Results 171 to 180 of about 497,128 (308)

In silico analysis of mycobacteriophage Ms6

, 2017
Trabalho Final de Mestrado Integrado, Ciências Farmacêuticas, Universidade de Lisboa, Faculdade de Farmácia ...
openaire   +1 more source

In-Silico Analysis of a Yeast Gene

This research presents a fully in-silico analysis of a yeast gene using publicly available bioinformatics tools. The study covers: DNA sequence retrieval from NCBI GenBank. Nucleotide composition analysis and calculation of GC content. Protein translation using the ExPASy Translate Tool.
openaire   +1 more source

Carboranyl‐Curcuminoids for the Neutron Capture‐Based Treatment of Amyloid Aggregates in Alzheimer's Disease

Advanced Science, EarlyView.
The 10B‐enriched monocarbonyl analog of curcumin (BMAC) 10B‐9 enables site‐specific Boron Neutron Capture Therapy (BNCT) on amyloid‐β (Aβ) fibrils. Neutron irradiation induces histidine oxidation and fibril destabilization, as revealed by 1H‐NMR and FESEM analyses.
Sebastiano Micocci, Stefano Parisotto, Diego Alberti, Alberto Lanfranco, Valeria Bitonto, Polyssena Renzi, Martina Salmi, Andrea Magnani, Federica Dal Bello, Katiuscia Pagano, Laura Ragona, Nicoletta Protti, Annamaria Deagostino, Simonetta Geninatti Crich   +13 more
wiley   +1 more source

In Silico Analysis of the Dual Role of Tumor Microenvironment on Colon Cancer Subtypes. [PDF]

Cancer Inform
Kehinde C, Livesey M, Manganyi Y, Bendou H.   +3 more
europepmc   +1 more source

Vorinostat Potentiates Chemoimmunotherapy in Immune‐Enriched Pancreatic Cancer

Advanced Science, EarlyView.
Immune‐enriched pancreatic cancer does not confer a significant survival advantage. SAHA sensitizes these “hot” tumors to chemoimmunotherapy by disrupting a FASN/PARP9‐driven “metabolic trap” and enhancing CD8+ T cell function. A CD8high/FASNhigh/PARP9high signature identifies patients who are most likely to benefit from the “gemcitabine‐nivolumab‐SAHA”
Chen Chen, Dingru Li, Yingna Liao, Zehua Wang, Chunbin Zhu, Zifeng Zhang, Liquan Jin, Yueyue Chen, Jiaoshun Chen, Junyi Xu, Miaoyan Wei, Rong Tang, Xianjun Yu, Si Shi   +13 more
wiley   +1 more source

NKGD2 Ligands (NKG2DLs) in Breast Cancer: In Silico Analysis and Narrative Review. [PDF]

Int J Mol Sci
Peña-López J, Gámez-Pozo A, Trilla-Fuertes L, Becerril-Gómez F, Mendiola M, Heredia V, Yébenes L, Castelo B, Martínez-Marín V, Espinosa E, Zamora P, Alba-Bernal A, Aguirre-Portolés C, Pérez-Martínez A.   +13 more
europepmc   +1 more source

Leveraging Artificial Intelligence and Large Language Models for Cancer Immunotherapy

Advanced Science, EarlyView.
Cancer immunotherapy faces challenges in predicting treatment responses and understanding resistance mechanisms. Artificial intelligence (AI) and machine learning (ML) offer powerful solutions for cancer immunotherapy in patient stratification, biomarker discovery, treatment strategy optimization, and foundation model development.
Xinchao Wu, Mengtao Sun, Lusheng Li, Jieqiong Wang, Shibiao Wan   +4 more
wiley   +1 more source

Immunogenicity of Adalimumab in Bacterial Molecular Mimicry: In Silico Analysis. [PDF]

JMIR Bioinform Biotechnol
Pachón-Suárez DI, Mejía-Salgado G, Correa O, Sánchez A, Munera M, de-la-Torre A.   +5 more
europepmc   +1 more source

CTBPro: A Next‐Generation Cholera Toxin Subunit B‐Based Neuroanatomical Tracer With Superior Brightness, Stability, and Sensitivity for Enhanced Neural Circuit Mapping

Advanced Science, EarlyView.
CTBPro is a next‐generation cholera toxin B–based tracer engineered by fusing CTB to the ultra‐stable fluorescent protein mBaojin. Exhibiting markedly enhanced molar brightness, CTBPro enables high‐fidelity neuronal labeling across multiple administration routes.
Xinghua Quan, Yude Lou, Huiqi Xie, Yifei Wang, Yanzhe Zhang, Yiran Ge, Linhe Yang, Xiaoxuan Zhang, Qingmiao Zhou, Huaizong Shen, Longxing Cao, Xin Jin, Jie‐Min Jia   +12 more
wiley   +1 more source

In silico analysis and comparison of the metabolic capabilities of different organisms by reducing metabolic complexity. [PDF]

Microbiome
Vayena E, Ataman M, Hatzimanikatis V.
europepmc   +2 more sources