Results 191 to 200 of about 497,128 (308)
In silico analysis of selected polyphenols as potential multitarget rheumatoid arthritis modifying agents. [PDF]
Mol Biol RepSharma S +3 more
europepmc +1 more source
In silico analysis of polyketide synthases
, 2010 With the development of new high capacity DNA sequencing techniques the use of a computational approach in biology is gaining even greater importance. In this thesis several of the bioinformatic methods have been employed on one class of enzymes – polyketide synthases (PKSs) - which were used to decode information stored in DNA into its more useful ...
openaire +2 more sources
Advanced Science, EarlyView.ABSTRACT The muscle capsule of Trichinella is a critical structure that impedes immune attacks and drug penetration, yet the molecular mechanisms underlying its formation remain poorly understood. Using a high‐quality super‐pangenome comprising 12 Trichinella species, we compared extensive genomic variations between encapsulating and non‐encapsulating ...
Qingbo Lv +8 more
wiley +1 more source
Advanced Science, EarlyView.The authors complement bovine pan‐SV with massive novel structural variations (SVs) identified through long‐read sequencing of 83 globally distributed cattle breeds. Repetitive sequence‐mediated SVs (rep‐SV) exhibit distinct dynamic patterns throughout cattle sub‐speciation and/or domestication processes, including uneven distribution between chr‐X and
Zhifan Guo +16 more
wiley +1 more source
Integrative In Silico Analysis of miRNA-mRNA Regulatory Networks in the Prefrontal Cortex of Individuals with Psychiatric Disorders Who Died by Suicide. [PDF]
Int J Mol SciCortéz-Sánchez JL +13 more
europepmc +1 more source
Advanced Science, EarlyView.This study identifies SNRPF as a critical oncogenic driver in ovarian cancer. By regulating a self‐sustaining SNRPF–DDX24–E2F4 feedback loop through intron retention and nonsense‐mediated decay, SNRPF couples RNA splicing with transcriptional regulation to promote tumor progression.
Yingwei Li +4 more
wiley +1 more source
Integrated in vivo and in silico analysis of immune gene expression in cattle infected with Brucella abortus. [PDF]
Sci RepMabrouk DM, El-Diasty M, Abdel-Aziem SH.
europepmc +1 more source
A Modular and Programmable Cas13d Platform for RNA Single Nucleotide Variant Detection
Advanced Science, EarlyView.A scenario‐guided Cas13d platform enables configurable single nucleotide variant ribonucleic acid diagnostics through rule‐based guide design and ribonucleic acid binding domain engineering, supporting amplification‐free ultrasensitive detection and amplification‐coupled robust detection for accurate mutation classification in clinical tumor specimens.
Zeyu Wang +8 more
wiley +1 more source
Advanced Science, EarlyView.Laterally spreading tumors (LSTs) are precancerous colorectal lesions characterized by a flat morphology. This study reveals a mechanochemical pathway through which a soft matrix microenvironment diminishes spatial constraints in intestinal adenomas. This process promotes deficiencies in tight junction proteins, mediated by the mechanoreceptor ADORA2B ...
Jiamin Zhong +21 more
wiley +1 more source
In vitro and in silico analysis of the fungicidal potential of secondary metabolites from a bacterial endophyte against Botrytis cinerea. [PDF]
BMC BiotechnolMaumela P, Serepa-Dlamini MH.
europepmc +1 more source