Results 141 to 150 of about 115,013,792 (297)

Super‐Multiplexed Label‐Free Raman Imaging Uncovers Novel Testicular Metabolic Couplings for Residual Body and Spermatogonial Differentiation

open access: yesAdvanced Science, EarlyView.
Super‐multiplexed Label‐free Raman Imaging (SLRI) enables 2D/3D metabolic mapping of intact Drosophila testes. Moving beyond descriptive morphology, it establishes a multidimensional tool for tissue metabolic remodeling, and offers a generalizable platform for complex tissue analysis, with implications extending to development and disease. ABSTRACT The
Jiaxin Li   +23 more
wiley   +1 more source

Crop genetic resource policy: the role of ex situ genebanks [PDF]

open access: yes
The world-wide capacity of genebanks for ex situ conservation of crop genetic resources has increased greatly since the 1970s, improving the access of crop breeders to landraces and wild and weedy relatives.
Wright, Brian D.
core  

Aberrant GRP78 Phase Transition Sustains Endothelial IRE1α Signaling and Drives Blood–Brain Barrier Failure in Cerebral Amyloid Angiopathy

open access: yesAdvanced Science, EarlyView.
Vascular Aβ40 corrupts GRP78 phase behavior in brain endothelial cells, sustaining IRE1α–TRAF2–JNK signaling and driving apoptosis, tight junction loss, and blood–brain barrier failure in cerebral amyloid angiopathy. Pharmacological IRE1α inhibition restores vascular integrity, reduces leakage, and improves functional outcomes, revealing a targetable ...
Honglin Zheng   +19 more
wiley   +1 more source

A Future for Small Farms? Biodiversity and Sustainable Agriculture [PDF]

open access: yes
Small farms play a crucial role in conserving the agricultural biodiversity that underpins long-term food security worldwide. Particularly in centers of crop genetic diversity – such as Mesoamerica in the case of maize (corn) and the Andean region in the
James Boyce
core  

Climate Change Dependence in Ex Situ Conservation of Wild Medicinal Plants in Crete, Greece. [PDF]

open access: yesBiology (Basel), 2023
Bariotakis M   +13 more
europepmc   +1 more source

Engineering a 660 nm‐Responsive Optogenetic Inducer of Pyroptosis for Precision Cancer Therapy

open access: yesAdvanced Science, EarlyView.
This study reports a bioorthogonal pyroptosis inducer, PyroRACS. By using a red‐light‐responsive Cre‐On genetic switch to control the expression of highly cytotoxic GSDMDNT, PyroRACS enables the artificial induction of pyroptosis with precise spatiotemporal control.
Mengkai Zhang   +5 more
wiley   +1 more source

Strategies for the in-situ and ex-situ conservation of timber shipwreeks and artefacts with special reference to the maritime archaeological excavations at Galle Harbour

open access: yes, 2008
The implementation of the waterlogged wood conservation has important implication for Sri Lanka. Firstly, there is a diverse and significant cultural heritage (multi user environment) in the sea.
Kasturi, KAA
core  

The economics of agrobiodiversity conservation for food security under climate change [PDF]

open access: yes
Subsistence-based and natural resource-dependent societies are especially vulnerable to climate change. In such contexts, food security needs to be strengthened by investing in the adaptability of food systems.
Pascual, Unai   +3 more
core  

Deltacoronavirus Modulates circRNA cGLIS3 Metabolism to Evade Host Antiviral Response

open access: yesAdvanced Science, EarlyView.
This study reveals that both deltacoronavirus nucleocapsid protein and host RNA binding protein IGF2BP2 promote circular RNA GLIS3 (cGLIS3) biogenesis by binding to GLIS3 pre‐mRNA. The m6A modification‐mediated cGLIS3‐IGF2BP2 interaction weakens RNase L‐mediated degradation of cGLIS3 while facilitates a ubiquitin‐dependent degradation of IGF2BP2, thus ...
Liuyang Du   +10 more
wiley   +1 more source

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