Results 41 to 50 of about 384,457 (306)
The newfound relationship between extrachromosomal DNAs and excised signal circles
FEBS Letters, EarlyView.Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley +1 more source
In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS
FEBS Letters, EarlyView.We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka +11 more
wiley +1 more source
In situ conservation of crop wild relatives [PDF]
, 2015 Poster presented at 13. Meeting of the Subsidiary Body on Scientific, Technical and Technological Advice (SBSTTA) held in FAO, Rome (Italy), 18-22 Feb ...
Danielyan, A. +5 more
core +3 more sources
Adaptation to Climate Change and the Role of Agrobiodiversity [PDF]
, 2007 The world’s biological diversity is eroding. This concerns in particular the entire agri-cultural diversity of genes, species and their agrarian ecosystems, the resource base for food. With species becoming extinct, mankind is jeopardised.
Kotschi, Johannes
core
Structural biology of ferritin nanocages
FEBS Letters, EarlyView.Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley +1 more source
Ark or park: the need to predict relative effectiveness of ex situ and in situ conservation before attempting captive breeding [PDF]
, 2015 1. When species face extinction, captive breeding may be appropriate. However, captive breeding may be unsuccessful, while reducing motivation and resources for in situ conservation and impacting wild source populations. Despite such risks, decisions are
Ashbrook K. +11 more
core +1 more source
FEBS Open Bio, EarlyView.ZFAS1 is a lncRNA promoting cell proliferation and migration, exhibiting high expression in various cancers. It is conserved, widely expressed, and produces multiple splice variants with unclear roles. We identified several splice variants in hepatocyte models, and found that inhibiting or suppressing regulators of the unfolded protein response (PERK ...
Sébastien Soubeyrand +2 more
wiley +1 more source
Conservation of the Lion: Preventing an Africa without the African Lion [PDF]
, 2018 The African lion (Panthera leo) population is diminishing rapidly, approximately 43 percent since 1993. The species is currently listed as vulnerable by the International Union for Conservation of Nature (IUCN).
Kamyk, Courtney
core +2 more sources
YIPFα1A expression is regulated by multilayered molecular mechanisms
FEBS Open Bio, EarlyView.YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji +2 more
wiley +1 more source
Criteria for rapid sliding I.: a review of Vaiont case [PDF]
, 2010 Vaiont slide has been represented by a model of two interacting evolutive wedges. Mass conservation during the motion implies that the upper wedge transfers mass to the lower one through an internal shearing plane.
Alonso Pérez de Agreda, Eduardo +1 more
core +2 more sources