Results 51 to 60 of about 115,013,792 (297)

Regulation of the lncRNA NEAT1 by p53‐ΔNp63 crosstalk modulates the DNA damage response and therapeutic efficacy in HNSCC

Molecular Oncology, EarlyView.
In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico, Veronica La Banca, Silvia D'Amico, Stefano Scalera, Sara Nicolai, Angelo Peschiaroli   +5 more
wiley   +1 more source

Extracellular matrix remodeling and immune reprogramming drive residual tumor progression of liver cancer after incomplete microwave ablation

Molecular Oncology, EarlyView.
Incomplete microwave ablation (iMWA) of liver cancer triggers a biphasic progression in residual tumors. At Day 3, the microenvironment is characterized by acute inflammatory responses and extracellular matrix (ECM) remodeling. By Day 14, a profound shift occurs toward oncogenic signal transduction and immunosuppression, marked by macrophage ...
Yu Liu, Yubei He, Nikolaus Berndt, Michael Mülleder, Kathrin Textoris‐Taube, Jing Guo, Matthias Stechele, Justus Ramtke, Shraga Nahum Goldberg, Lynn Jeanette Savic   +9 more
wiley   +1 more source

In Situ Conservation of Dry Meadows

Land
Grassland ecosystems are increasingly vulnerable as they are threatened by both intensive agriculture and abandonment of land use, which leads to overgrowth with scrub vegetation and forest. Given that meadows are habitat types of very high biodiversity, their loss significantly reduces local biodiversity.
Bavcon, Jože, Malovrh, Katja, Tomšič, Maja, Ravnjak, Blanka   +3 more
openaire   +2 more sources

TRPML1 agonist ML‐SA5 attenuates pulmonary fibroblast activation by suppressing mTOR and restoring autophagic flux

FEBS Open Bio, EarlyView.
TGF‐β1 stimulation downregulates lysosomal channel TRPML1 in pulmonary fibroblasts. The TRPML1 agonist ML‐SA5 suppressed fibroblast‐to‐myofibroblast activation and collagen production. Mechanistically, ML‐SA5 inhibited mTOR phosphorylation, restored autophagic flux, and its effects were enhanced by rapamycin (mTOR inhibitor) and reversed by MHY1485 ...
Jiatong Yao, Xiaoting Kang, Lulu Meng, Shaoxuan Zhang, Qiujie Li, Jinyu Zhou, Mengyue Xue, Chu Li, Hua Zhu, Pengzhou Hang, Jing Zhao   +10 more
wiley   +1 more source

Genetic Diversity and Population Structure of Wild Ribes Populations (Ribes nigrum, Ribes rubrum and Ribes uva-crispa) in the Netherlands Assessed Using MobiSeq Genotyping

Horticulturae
The development of effective conservation and management strategies for wild Ribes populations requires a comprehensive understanding of genetic diversity and population structure of these taxa, but only a few genetic studies exist, and these have ...
M. J. M. Smulders, D. Michels, L. P. Kodde, G. D. Esselink, S. M. E. de Mits, P. Copini, J. Buiteveld   +6 more
doaj   +1 more source

Inverse Identification of Energy‐Dependent Laser Absorptivity in NiTi Laser Powder‐Bed Fusion via Calibrated Melt Pool Simulation

Advanced Engineering Materials, EarlyView.
A combined experimental–computational framework identifies energy‐dependent laser absorptivity for NiTi in laser powder‐bed fusion, applicable to conduction and transition modes. Single‐track experiments and thermofluid smoothed particle hydrodynamics simulations are coupled through inverse analysis of melt pool geometry.
Mohamadreza Afrasiabi, Hadi Moutablaleh, Ignatius A. Setiawan, Mehrshad Mehrpouya   +3 more
wiley   +1 more source

Integrating scientometric analysis and zoo population data to identify knowledge and conservation gaps in three Neotropical canids

Discover Animals
This study provides an overview of the scientific literature and zoo distribution data for three threatened canid species in Brazil: the short-eared dog (Atelocynus microtis), the hoary fox (Lycalopex vetulus), and the bush dog (Speothos venaticus), for ...
Leandro Ferreira Costa, Gabriela Ramos, Gustavo Nunes de Almeida, Luiza Figueiredo Passos, Cristiano Schetini de Azevedo, Maria Rita Silvério Pires   +5 more
doaj   +1 more source

Adaptive Foam 3D Printing of Ultralight and Multifunctional Materials

Advanced Engineering Materials, EarlyView.
Adaptive foam 3D printing, enabled by expandable microspheres, imparts cellular structures to thermoplastic and thermosetting polymers, manufactured through a variety of processes including fused filament fabrication, direct ink writing, digital light processing, and inkjet printing.
Nariman Rajabifar, Amir Ameli
wiley   +1 more source

Potato diversity at height: multiple dimensions of farmer-driven in-situ conservation in the Andes [PDF]

, 2009
In-situ conservation Two types of in-situ conservation of crop genetic resources can be distinguished: farmer-driven and externally driven. The first is subject of this thesis and refers to the persistence of potato genetic resources in areas where ...
de Haan, S., Haan, S., de
core  

Conservation in Kansas

, 2011
Report covers Fiscal Year 2010 and 2011, with planned activities listed for Fiscal Year 2012.<br>Continues title: Soil conservation in Kansas which previously was continued by: Conservation in ...
Kansas. State Conservation Commission
core   +1 more source