Results 11 to 20 of about 115,018,060 (255)

Lime Peel Oil–Incorporated Rosin-Based Antimicrobial In Situ Forming Gel

Gels, 2022
Localized intra-periodontal pocket drug delivery using an injectable in situ forming gel is an effective periodontitis treatment. The aqueous insoluble property of rosin is suitable for preparing a solvent exchange-induced in situ forming gel. This study
Ei Mon Khaing, Jongjan Mahadlek, Siriporn Okonogi, Thawatchai Phaechamud   +3 more
doaj   +4 more sources

Formulation, in-vitro characterization and clinical evaluation of curcumin in-situ gel for treatment of periodontitis

Drug Delivery, 2017
This study aimed to develop syringeable in-situ curcumin (cur) gel for the treatment of periodontal pockets as well as to evaluate the clinical efficacy of Cur in-situ gel formulation.
Maha M. A. Nasra, Heba M. Khiri, Heba A. Hazzah, Ossama Y. Abdallah   +3 more
doaj   +2 more sources

Depot injectable atorvastatin biodegradable in situ gel: development, optimization, in vitro, and in vivo evaluation

Drug Design, Development and Therapy, 2016
Tarek A Ahmed,1,2 Yasser A Alharby,1 Abdel-Rahim M El-Helw,1 Khaled M Hosny,1,3 Khalid M El-Say1,21Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, King Abdulaziz University, Jeddah, Saudi Arabia; 2Department of Pharmaceutics and
Ahmed TA, Alharby YA, El-Helw AM, Hosny KM, El-Say KM   +4 more
doaj   +1 more source

Design and Comparative Evaluation of Vancomycin HCl-Loaded Rosin-Based In Situ Forming Gel and Microparticles

Gels, 2022
Vancomycin hydrochloride (HCl) is a glycopeptide antibiotic used to treat serious or life-threatening infections, and it reduces plaque scores and gingivitis in periodontal patients.
Tiraniti Chuenbarn, Jitnapa Sirirak, Sarun Tuntarawongsa, Siriporn Okonogi, Thawatchai Phaechamud   +4 more
doaj   +1 more source

Development and Characterization of Dual-Loaded Niosomal Ion-Sensitive In Situ Gel for Ocular Delivery. [PDF]

Gels
The study investigates the development and characterization of dual-loaded niosomes incorporated into ion-sensitive in situ gel as a potential drug delivery platform for ophthalmic application.
Gugleva V, Mihaylova R, Kamenova K, Zheleva-Dimitrova D, Stefanova D, Tzankova V, Zaharieva MM, Najdenski H, Forys A, Trzebicka B, Petrov PD, Momekova D.   +11 more
europepmc   +2 more sources

Piperine-Loaded In Situ Gel: Formulation, In Vitro Characterization, and Clinical Evaluation against Periodontitis

, 2023
Periodontitis is an inflammatory disorder associated with dysbiosis and characterized by microbiologically related, host-mediated inflammation that leads to the damage of periodontal tissues including gingiva, connective tissues, and alveolar bone.
Poornima K. Gopalakrishna, Amr Selim Abu Lila, Rajamma Abburu Jayaramu, Hadil Faris Alotaibi, Nikhil V. Suresh, El-Sayed Khafagy, Sateesha Shivally Boregowda, Ahmad J. Obaidullah, Afrasim Moin, Shruthi Eshwar   +9 more
core   +1 more source

Development and Characterization of Novel In-Situ-Forming Oleogels

Pharmaceutics, 2023
PLGA-based in situ forming implants (ISFI) often require a high amount of potentially toxic solvents such as N methyl-Pyrrolidone (NMP). The aim of the present study was to develop lipid in-situ-forming oleogels (ISFOs) as alternative delivery systems ...
Anne Dümichen, Henrike Lucas, Marie-Luise Trutschel, Karsten Mäder   +3 more
doaj   +1 more source

Nanoparticles laden in situ gelling system for ocular drug targeting

Journal of Advanced Pharmaceutical Technology & Research, 2013
Designing an ophthalmic drug delivery system is one of the most difficult challenges for the researchers. The anatomy and physiology of eye create barriers like blinking which leads to the poor retention time and penetration of drug moiety.
Divya Kumar, Nidhi Jain, Neha Gulati, Upendra Nagaich   +3 more
doaj   +1 more source

Preparation and Characterization of Ion-Sensitive Brimonidine Tartrate In Situ Gel for Ocular Delivery

Pharmaceuticals, 2023
Brimonidine tartrate (BRT) is a highly selective α2 adrenergic receptor agonist as treatment for patients with open angle glaucoma and high intraocular pressure.
Haonan Xu, Ye Liu, Lu Jin, Xu Chen, Xinghao Chen, Qiao Wang, Zhan Tang   +6 more
doaj   +1 more source

Nanoparticles laden in situ gel for sustained ocular drug delivery

Journal of Pharmacy and Bioallied Sciences, 2013
Proper availability of drug on to corneal surface is a challenging task. However, due to ocular physiological barriers, conventional eye drops display poor ocular bioavailability of drugs (< 1%).
Himanshu Gupta, Mohammed Aqil, Roop K Khar, Asgar Ali, Aseem Bhatnagar, Gaurav Mittal   +5 more
doaj   +1 more source