Results 1 to 10 of about 297,584 (148)
Journal of Chemical Theory and Computation, 2021 Many important processes affecting the earth's climate are determined by the physical properties of seawater. In addition, desalination of seawater is a significant source of drinking water for the human population living in coastal areas. Since the physical properties of seawater governing these processes depend on the molecular interactions among its
Ivan M. Zeron +4 more
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Orvosi Hetilap, 2016 Introduction: Simulation models can contribute substantially to our understanding and ability to control the dynamic processes underlying impaired glucose metabolism in diabetic patients. Aim: The aim of this paper is to outline a new comprehensive, physiologically-based dynamic model of glucose homeostasis incorporating up-to-date quantitative ...
DiĂł, MihĂĄly +2 more
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Scientific Reports, 2022 Standing radiographs play an important role in the characterization of spinal sagittal alignment, as they depict the spine under physiologic loading conditions.
Benjamin Hajnal +6 more
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Frontiers in Neuroscience, 2021 CNS disorders are lagging behind other indications in implementing genotype-dependent treatment algorithms for personalized medicine. This report uses a biophysically realistic computer model of an associative and dorsal motor cortico-striatal-thalamo ...
Athan Spiros, Hugo Geerts, Hugo Geerts
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lazar: A modular predictive toxicology framework
Frontiers in Pharmacology, 2013 lazar (lazy structure-activity relationships) is a modular framework for predictive toxicology. Similar to the read across procedure in toxicological risk assessment, lazar creates local QSAR models for each compound to be predicted. Model developers can
Andreas eMaunz +5 more
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Frontiers in Pharmacology, 2013 Successful disease-modifying drug development for Alzheimer’s disease has hit a roadblock with the recent failures of amyloid-based therapies, highlighting the translational disconnect between preclinical animal models and clinical outcome.
Hugo eGeerts +5 more
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Scientific Reports, 2023 Total en bloc spondylectomy (TES) effectively treats spinal tumors. The surgery requires a vertebral body replacement (VBR), for which several solutions were developed, whereas the biomechanical differences between these devices still need to be ...
Agoston Jakab Pokorni +4 more
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Alzheimer’s Research & Therapy, 2018 Background Despite a tremendous amount of information on the role of amyloid in Alzheimer’s disease (AD), almost all clinical trials testing this hypothesis have failed to generate clinically relevant cognitive effects.
Hugo Geerts +2 more
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Frontiers in Pharmacology, 2016 The current treatment of Parkinson’s disease with dopamine-centric approaches such as L-DOPA and dopamine agonists, although very succesfull, is in need of alternative treatment strategies, both in terms of disease modification and symptom management ...
Hugo eGeerts +4 more
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Frontiers in Pharmacology, 2014 Although many antipsychotics can reasonably control positive symptoms in schizophrenia, patients’ return to society is often hindered by negative symptoms and cognitive deficits.
Hugo eGeerts +4 more
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