Results 1 to 10 of about 620,275 (284)

Combined In Silico, In Vivo, and In Vitro Studies Shed Insights into the Acute Inflammatory Response in Middle-Aged Mice [PDF]

, 2013
We combined in silico, in vivo, and in vitro studies to gain insights into age-dependent changes in acute inflammation in response to bacterial endotoxin (LPS). Time-course cytokine, chemokine, and NO2-/NO3- data from "middle-aged" (6-8 months old) C57BL/
A Torres, AA Beharka, AK Schroder, C Franceschi, C Franceschi, C Nathan, CC Chow, CE Lagoa, CR Gomez, DC Morrison, DE Zak, Derek Barclay, Derya Unutmaz, DO Adams, E Alvarez, E Cevenini, EZ Bagci, EZ Bagci, F Aujard, F L’Episcopo, FM Ocasio, G Nieman, H Ochi, H Saito, H Wang, IR Turnbull, J Plowden, JM Cavaillon, JM Prince, John Bartels, K Tateda, KM Greeneltch, L Alvarez-Rodriguez, L Ferrucci, M Gurven, MA West, MJ Yang, R Kumar, R Ostan, RA Kohman, Rami A. Namas, RB Effros, RJ Fahy, RL Zhang, Rosemary Hoffman, Ruben Zamora, S Daun, S Gordon, SC Kang, SF Bradley, SN Zykova, T Inamizu, Timothy R. Billiar, TP Plackett, U Fagiolo, W Schumer, W Wiktor-Jedrzejczak, Y Hasegawa, Y Ito, Y Vodovotz, Y Vodovotz, Y Vodovotz, Yoram Vodovotz, Z Yang   +63 more
core   +14 more sources

New method to apply the lumbar lordosis of standing radiographs to supine CT-based virtual 3D lumbar spine models

Scientific Reports, 2022
Standing radiographs play an important role in the characterization of spinal sagittal alignment, as they depict the spine under physiologic loading conditions.
Benjamin Hajnal, Peter Endre Eltes, Ferenc Bereczki, Mate Turbucz, Jennifer Fayad, Agoston Jakab Pokorni, Aron Lazary   +6 more
doaj   +1 more source

Toward Predicting Impact of Common Genetic Variants on Schizophrenia Clinical Responses With Antipsychotics: A Quantitative System Pharmacology Study

Frontiers in Neuroscience, 2021
CNS disorders are lagging behind other indications in implementing genotype-dependent treatment algorithms for personalized medicine. This report uses a biophysically realistic computer model of an associative and dorsal motor cortico-striatal-thalamo ...
Athan Spiros, Hugo Geerts, Hugo Geerts
doaj   +1 more source

Impact of amyloid-beta changes on cognitive outcomes in Alzheimer’s disease: analysis of clinical trials using a quantitative systems pharmacology model

Alzheimer’s Research & Therapy, 2018
Background Despite a tremendous amount of information on the role of amyloid in Alzheimer’s disease (AD), almost all clinical trials testing this hypothesis have failed to generate clinically relevant cognitive effects.
Hugo Geerts, Athan Spiros, Patrick Roberts   +2 more
doaj   +1 more source

Predicting optimal hematocrit in silico [PDF]

, 2018
Optimal hematocrit $H_o$ maximizes oxygen transport. In healthy humans, the average hematocrit $H$ is in the range of 40-45$\%$, but it can significantly change in blood pathologies such as severe anemia (low $H$) and polycythemia (high $H$). Whether the
Audemar, Vassanti, Benyoussef, Abdelilah, Coupier, Gwennou, Ez-Zahraouy, Hamid, Farutin, Alexander, Harting, Jens, Misbah, Chaouqi, Podgorski, Thomas, Polack, Benoit, Prado, Gael, Shen, Zaiyi, Vlahovska, Petia M.   +11 more
core   +7 more sources

lazar: A modular predictive toxicology framework

Frontiers in Pharmacology, 2013
lazar (lazy structure-activity relationships) is a modular framework for predictive toxicology. Similar to the read across procedure in toxicological risk assessment, lazar creates local QSAR models for each compound to be predicted. Model developers can
Andreas eMaunz, Martin eGütlein, Micha eRautenberg, David eVorgrimmler, Denis eGebele, Christoph eHelma   +5 more
doaj   +1 more source

Comparison of anterior column reconstruction techniques after en bloc spondylectomy: a finite element study

Scientific Reports, 2023
Total en bloc spondylectomy (TES) effectively treats spinal tumors. The surgery requires a vertebral body replacement (VBR), for which several solutions were developed, whereas the biomechanical differences between these devices still need to be ...
Agoston Jakab Pokorni, Mate Turbucz, Rita Maria Kiss, Peter Endre Eltes, Aron Lazary   +4 more
doaj   +1 more source

A STRATEGY FOR DEVELOPING NEW TREATMENT PARADIGMS FOR NEUROPSYCHIATRIC AND NEUROCOGNITIVE SYMPTOMS IN ALZHEIMER’S DISEASE

Frontiers in Pharmacology, 2013
Successful disease-modifying drug development for Alzheimer’s disease has hit a roadblock with the recent failures of amyloid-based therapies, highlighting the translational disconnect between preclinical animal models and clinical outcome.
Hugo eGeerts, Hugo eGeerts, Athan eSpiros, Patrick eRoberts, Patrick eRoberts, Robert eCarr   +5 more
doaj   +1 more source

A HUMANIZED CLINICALLY CALIBRATED QUANTITATIVE SYSTEMS PHARMACOLOGY MODEL FOR HYPOKINETIC MOTOR SYMPTOMS IN PARKINSON’S DISEASE

Frontiers in Pharmacology, 2016
The current treatment of Parkinson’s disease with dopamine-centric approaches such as L-DOPA and dopamine agonists, although very succesfull, is in need of alternative treatment strategies, both in terms of disease modification and symptom management ...
Hugo eGeerts, Hugo eGeerts, Patrick eRoberts, Patrick eRoberts, Athan eSpiros   +4 more
doaj   +1 more source

Negative Symptoms in Schizophrenia: Exploring Glutamatergic Modulation Using a Computer-Based Quantitative Systems Pharmacology Approach

Frontiers in Pharmacology, 2014
Although many antipsychotics can reasonably control positive symptoms in schizophrenia, patients’ return to society is often hindered by negative symptoms and cognitive deficits.
Hugo eGeerts, Hugo eGeerts, Athan eSpiros, Patrick eRoberts, Patrick eRoberts   +4 more
doaj   +1 more source