Results 71 to 80 of about 497,128 (308)
Frontiers in Pharmacology, 2017 Escalating incidences of cancer, especially in developed and developing countries, demand evaluation of potential unexplored natural drug resources. Here, anticancer potential of 9-Ethyliminomethyl-12-(morpholin-4-ylmethoxy)-5,8,13,16-tetraaza -hexacene ...
Niveshika +4 more
doaj +1 more source
Importance of the biomass formulation for cancer metabolic modeling and drug prediction
iScience, 2021 Summary: Genome-scale metabolic reconstructions include all known biochemical reactions occurring in a cell. A typical application is the prediction of potential drug targets for cancer treatment.
María Moscardó García +4 more
doaj +1 more source
Exploring the metabolic network of the epidemic pathogen Burkholderia cenocepacia J2315 via genome-scale reconstruction [PDF]
, 2011 BACKGROUND: Burkholderia cenocepacia is a threatening nosocomial epidemic pathogen in patients with cystic fibrosis (CF) or a compromised immune system. Its high level of antibiotic resistance is an increasing concern in treatments against its infection.
Fang, K. +9 more
core +2 more sources
In Silico Analysis of Crustacean Hyperglycemic Hormone Family [PDF]
Marine Biotechnology, 2005 Through multiple sequence alignment and phylogenetic analysis, the subgrouping of the crustacean hyperglycemic hormone (CHH) family was updated using the most complete, nonredundant sequence data set. All sequences from insects were clustered into a distinct subbranch with characters closer to CHH subfamily I.
S H, Chen, C Y, Lin, C M, Kuo
openaire +2 more sources
FEBS Open Bio, EarlyView.CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point +7 more
wiley +1 more source
FEBS Open Bio, EarlyView.dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon +6 more
wiley +1 more source
In vitro and in vivo evaluation of cephalosporins for the treatment of Lyme disease. [PDF]
, 2018 BackgroundLyme disease accounts for >90% of all vector-borne disease cases in the United States and affect ~300,000 persons annually in North America.
Ambati, Aditya +9 more
core
FEBS Open Bio, EarlyView.Chemoresistance in bladder cancer: Macrophage recruitment associated with CXCL1, CXCL5 and CXCL8 expression is characteristic of Gemcitabine/Cisplatin (Gem/Cis) Non‐Responder tumors (right side) while Responder tumors did not show substantial tumor‐stromal crosstalk (left side). All biological icons are attributed to Bioicons: carcinoma, cancerous‐cell‐
Sophie Leypold +11 more
wiley +1 more source
In silico study of Bacillus spB201 amylase through protein sequence inspection
Journal of the Arab Society for Medical ResearchBackground/aim Bioinformatics is the automatic processing of biological information, and it is a helpful tool to study the structure-function relationship of various proteins.
Sameh Ben Mabrouk +3 more
doaj +1 more source
In silico characterization of boron transporter (BOR1) protein sequences in Poaceae species [PDF]
Journal of BioScience and Biotechnology, 2013 Boron (B) is essential for the plant growth and development, and its primary function is connected with formation of the cell wall. Moreover, boron toxicity is a shared problem in semiarid and arid regions. In this study, boron transporter protein (BOR1)
Ertuğrul Filiz
doaj