Results 91 to 100 of about 165,849 (202)

Personalized brain network models for assessing structure-function relationships

, 2018
Many recent efforts in computational modeling of macro-scale brain dynamics have begun to take a data-driven approach by incorporating structural and/or functional information derived from subject data.
Bansal, Kanika, Muldoon, Sarah Feldt, Nakuci, Johan   +2 more
core   +1 more source

Start & Stop: a PhysiCell and PhysiBoSS 2.0 add-on for interactive simulation control

BMC Bioinformatics
In computational biology, in silico simulators are vital for exploring and understanding the behavior of complex biological systems. Hybrid multi-level simulators, such as PhysiCell and PhysiBoSS 2.0, integrate multiple layers of biological complexity ...
Riccardo Smeriglio, Roberta Bardini, Alessandro Savino, Stefano Di Carlo   +3 more
doaj   +1 more source

Dichloro-Phenyl-Benzotriazoles: A New Selective Class of Human Respiratory Syncytial Virus Entry Inhibitors

Frontiers in Chemistry, 2019
Human Respiratory Syncytial Virus (RSV) is the primary cause of bronchopneumonia in infants and children worldwide. Clinical studies have shown that early treatments of RSV patients with ribavirin improve prognosis, even if the use of this drug is ...
Sandra Piras, Giuseppina Sanna, Antonio Carta, Paola Corona, Roberta Ibba, Roberta Loddo, Silvia Madeddu, Paola Caria, Suzana Aulic, Erik Laurini, Maurizio Fermeglia, Sabrina Pricl   +11 more
doaj   +1 more source

In silico design of magnesium implants: Macroscopic modeling

Journal of the Mechanical Behavior of Biomedical Materials, 2018
Magnesium-based biomedical implants offer many advantages versus traditional ones although some challenges are still present. In this context, mathematical modeling and computational simulation may be a useful and complementary tool to evaluate in silico the performance of magnesium biomaterials under different conditions.
Sanz Herrera, José Antonio, Reina Romo, Esther, Boccaccini, Aldo R.   +2 more
openaire   +4 more sources

Addressing current challenges in cancer immunotherapy with mathematical and computational modeling

, 2017
The goal of cancer immunotherapy is to boost a patient's immune response to a tumor. Yet, the design of an effective immunotherapy is complicated by various factors, including a potentially immunosuppressive tumor microenvironment, immune-modulating ...
Adler, Adam J., Konstorum, Anna, Laubenbacher, Reinhard, Vella, Anthony T.   +3 more
core   +1 more source

Simulating Brain Tumor Heterogeneity with a Multiscale Agent-Based Model: Linking Molecular Signatures, Phenotypes and Expansion Rate

, 2007
We have extended our previously developed 3D multi-scale agent-based brain tumor model to simulate cancer heterogeneity and to analyze its impact across the scales of interest.
Deisboeck, Thomas S., Strouthos, Costas G., Wang, Zhihui, Zhang, Le   +3 more
core   +1 more source

A Unified Whole Lung PBK Model for Inhalational Uptake of Gases and Aerosols in Men

CPT: Pharmacometrics & Systems Pharmacology
Assessing the risk or benefit of an inhaled substance is challenging due to the variety of forms it can take (gas, vapor, particle, or droplet) and the complex biological processes involved in its uptake and retention. Physiologically based kinetic (PBK)
Norman Nowak, Sylvia E. Escher, Katharina Schwarz   +2 more
doaj   +1 more source

In silico exploration of nitrogenase in Ensifer fredii unraveling structural homology functional and phylogenetic relationships and molecular dynamics

Discover Chemistry
The nitrogenase Fe protein, central to nitrogen fixation, has been extensively studied, However, the X-ray structure of the Nase-Fe protein from Ensifer fredii is essential for understanding its function and stability, yet this structure is absent from ...
Mohamed Hnini, Karim Rabeh
doaj   +1 more source

In silico modeling of targeted protein degradation

European Journal of Medicinal Chemistry
Targeted protein degradation (TPD) techniques, particularly proteolysis-targeting chimeras (PROTAC) and molecular glue degraders (MGD), have offered novel strategies in drug discovery. With rapid advancement of computer-aided drug design (CADD) and artificial intelligence-driven drug discovery (AIDD) in the biomedical field, a major focus has become ...
Wenxing Lv, Xiaojuan Jia, Bowen Tang, Chao Ma, Xiaopeng Fan, Xurui Jin, Zhangming Niu, Xin Han   +7 more
openaire   +2 more sources

Digitoids: a novel computational platform for mimicking oxygen-dependent firing of neurons in vitro

Frontiers in Neuroinformatics
IntroductionComputational models are valuable tools for understanding and studying a wide range of characteristics and mechanisms of the brain. Furthermore, they can also be exploited to explore biological neural networks from neuronal cultures. However,
Rachele Fabbri, Rachele Fabbri, Ermes Botte, Ermes Botte, Ermes Botte, Arti Ahluwalia, Arti Ahluwalia, Arti Ahluwalia, Chiara Magliaro, Chiara Magliaro, Chiara Magliaro   +10 more
doaj   +1 more source