Results 81 to 90 of about 165,849 (202)

In silico Design of Truncated Omp31 Protein of Brucella melitensis: Its Cloning and High Level Expression in Escherichia coli

Vaccine Research, 2014
Introduction: Omp31 is animmunodominant and protective antigen conserved in Brucella species and a good candidate for vaccine design. Material & methods: The present study aimed at in silico design of the truncated Omp31 (TOmp31) using bioinformatic ...
Maryam Golshani, Payam Zandi, Saeid Bouzari   +2 more
doaj  

Modeling ChIP Sequencing In Silico with Applications

PLoS Computational Biology, 2008
ChIP sequencing (ChIP-seq) is a new method for genomewide mapping of protein binding sites on DNA. It has generated much excitement in functional genomics. To score data and determine adequate sequencing depth, both the genomic background and the binding sites must be properly modeled.
Zhengdong D Zhang, Joel Rozowsky, Michael Snyder, Joseph Chang, Mark Gerstein   +4 more
openaire   +3 more sources

Computational modeling and simulation in oncology

Clinical and Translational Discovery
Computational modeling and simulation are playing an increasingly important role in oncology, bridging biological research, data science and clinical practice to better understand cancer complexity and inform therapeutic development.
Christian Baumgartner
doaj   +2 more sources

Flavopereirine—An Alkaloid Derived from Geissospermum vellosii—Presents Leishmanicidal Activity In Vitro

Molecules, 2019
Chemotherapy is limited in the treatment of leishmaniasis due to the toxic effects of drugs, low efficacy of alternative treatments, and resistance of the parasite.
João Victor da Silva e Silva, Helliton Patrick Cordovil Brigido, Kelly Cristina Oliveira de Albuquerque, Josiwander Miranda Carvalho, Jordano Ferreira Reis, Lara Vinhal Faria, Márlia Regina Coelho-Ferreira, Fernando Tobias Silveira, Agnaldo da Silva Carneiro, Sandro Percário, Andrey Moacir do Rosário Marinho, Maria Fâni Dolabela   +11 more
doaj   +1 more source

APOBEC-related mutagenesis and neo-peptide hydrophobicity: implications for response to immunotherapy. [PDF]

, 2019
Tumor-associated neo-antigens are mutated peptides that allow the immune system to recognize the affected cell as foreign. Cells carrying excessive mutation load often develop mechanisms of tolerance.
Boichard, Amélie, Frampton, Garrett M, Goodman, Aaron, Kurzrock, Razelle, Lippman, Scott, Pham, Timothy V, Tamayo, Pablo, Tsigelny, Igor F, Yeerna, Huwate   +8 more
core  

In silico characterization and homology modeling of Nile tilapia (Oreochromis niloticus) Hsp70cBi and Hsp70cBc proteins

Heliyon
The molecular chaperone heat shock proteins 70 (Hsp70) play a pivotal role in preserving cellular integrity and managing stress. This study extensively examined two Hsp70 proteins, On-Hsp70cBi, inducible, and On-Hsp70cBc, constitutively expressed, in ...
Geraldine B. Dayrit, Normela Patricia F. Burigsay, Emmanuel M. Vera Cruz, Mudjekeewis D. Santos   +3 more
doaj   +1 more source

In silico Protein Structural Modeling and Active binding site Evaluation of Streptococcus pneumoniae [PDF]

, 2009
Structure function relation of glucose kinese in Streptococcus pneumoniae. However, a solved structure for _Streptococcus pneumoniae_ glucose kinese is not available at the protein data bank.
M. Balakrishnan, M. Ramachandran, R.C. Srivastava   +2 more
core   +1 more source

A Process Algebraical Approach to Modelling Compartmentalized Biological Systems [PDF]

, 2007
This paper introduces Protein Calculus, a special modeling language designed for encoding and calculating the behaviors of compartmentilized biological systems.
Ihekwaba, Adaoha, Mardare, Radu
core   +1 more source

Pharmacophore modeling and in silico toxicity assessment of potential anticancer agents from African medicinal plants

Drug Design, Development and Therapy, 2016
Fidele Ntie-Kang,1,2,* Conrad Veranso Simoben,1,2,* Berin Karaman,1 Valery Fuh Ngwa,3 Philip Neville Judson,4 Wolfgang Sippl,1 Luc Meva’a Mbaze5 1Department of Pharmaceutical Chemistry, Martin-Luther University of Halle-Wittenberg, Halle (Saale ...
Ntie-Kang F, Simoben CV, Karaman B, Ngwa VF, Judson PN, Sippl W, Mbaze LM   +6 more
doaj  

Exploring the anti-inflammatory effects of bioactive compounds from assam tea clones: in silico and in vitro approaches

International Journal of Secondary Metabolite
The consumption of tea, derived from Camellia sinensis, ranks second globally after water. This research explores the anti-inflammatory properties of tea plant varieties from Assam, including TEEN ALI, TV-17, and TV-22, through a comprehensive approach ...
Hariram Natarajan, Nishanth Pitcham
doaj   +1 more source