Results 11 to 20 of about 123,989 (167)

In Silico Analysis of Variants of Uncertain Significance in AP4S1 Gene

Bioscientific Review, 2020
Hereditary spastic paraplegia is a group of heterogeneous neurological disorders with genetic etiologies. It is characterized by spasticity in lower limbs along with neurological complications.
Sobia Nazir Chaudry, Ammara Akhtar, Ayman Naeem, Dr. Mureed Husaain   +3 more
doaj   +1 more source

Predicting the Skin Sensitization Potential of Small Molecules with Machine Learning Models Trained on Biologically Meaningful Descriptors

Pharmaceuticals, 2021
In recent years, a number of machine learning models for the prediction of the skin sensitization potential of small organic molecules have been reported and become available. These models generally perform well within their applicability domains but, as
Anke Wilm, Marina Garcia de Lomana, Conrad Stork, Neann Mathai, Steffen Hirte, Ulf Norinder, Jochen Kühnl, Johannes Kirchmair   +7 more
doaj   +1 more source

AllerTOP - a server for in silico prediction of allergens [PDF]

BMC Bioinformatics, 2013
Abstract Background Allergy is a form of hypersensitivity to normally innocuous substances, such as dust, pollen, foods or drugs. Allergens are small antigens that commonly provoke an IgE antibody response. There are two types of bioinformatics-based allergen prediction.
Ivan Dimitrov, Darren R. Flower, Irini A. Doytchinova   +2 more
openaire   +3 more sources

In silico prediction of the granzyme B degradome [PDF]

BMC Genomics, 2011
Granzyme B is a serine protease which cleaves at unique tetrapeptide sequences. It is involved in several signaling cross-talks with caspases and functions as a pivotal mediator in a broad range of cellular processes such as apoptosis and inflammation.
Wee Lawrence JK, Er Esmond PS, Ng Lisa FP, Tong JC   +3 more
openaire   +3 more sources

FVIII Immunogenicity—Bioinformatic Approaches to Evaluate Inhibitor Risk in Non-severe Hemophilia A

Frontiers in Immunology, 2020
The life-long inhibitor risk in non-severe hemophilia A has been an important clinical and research focus in recent years. Non-severe hemophilia A is most commonly caused by point mutation, missense F8 genotypes, of which over 500 variants are described.
Daniel P. Hart
doaj   +1 more source

In Vitro and In Silico ADME Prediction [PDF]

, 2018
Pharmacokinetic issues have been identified as a major cause for the attrition of new chemical entities in drug discovery. High development costs and time investments are associated with the discovery of such issues during clinical drug development.
Effinger, Angela, O'Driscoll, Caitriona M., McAllister, Mark, Fotaki, Nikoletta   +3 more
openaire   +1 more source

Evaluation of in silico predictors on short nucleotide variants in HBA1, HBA2, and HBB associated with haemoglobinopathies

eLife, 2022
Haemoglobinopathies are the commonest monogenic diseases worldwide and are caused by variants in the globin gene clusters. With over 2400 variants detected to date, their interpretation using the American College of Medical Genetics and Genomics (ACMG ...
Stella Tamana, Maria Xenophontos, Anna Minaidou, Coralea Stephanou, Cornelis L Harteveld, Celeste Bento, Joanne Traeger-Synodinos, Irene Fylaktou, Norafiza Mohd Yasin, Faidatul Syazlin Abdul Hamid, Ezalia Esa, Hashim Halim-Fikri, Bin Alwi Zilfalil, Andrea C Kakouri, ClinGen Hemoglobinopathy Variant Curation Expert Panel, Marina Kleanthous, Petros Kountouris   +16 more
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A Computational Workflow to Predict Biological Target Mutations: The Spike Glycoprotein Case Study

Molecules, 2023
The biological target identification process, a pivotal phase in the drug discovery workflow, becomes particularly challenging when mutations affect proteins’ mechanisms of action.
Pietro Cozzini, Federica Agosta, Greta Dolcetti, Alessandro Dal Palù   +3 more
doaj   +1 more source

Prediction and Mapping of Potential Bioactive Peptide from Traditional Fermented Anchovy (Rusip) using Bioinformatics Approaches

Squalen, 2023
Bioactive peptides can be obtained from various sources, one of which is a fermented food. Rusip is a traditional Indonesian fermented food made from anchovy (Stolephorus spp.), which has the potential as a source of bioactive peptides.
Muhammad Alfid Kurnianto, Fathma Syahbanu, Hamidatun Hamidatun, Yushinta Aristina Sanjaya   +3 more
doaj   +1 more source

In silico-guided sequence modifications of K-ras epitopes improve immunological outcome against G12V and G13D mutant KRAS antigens [PDF]

PeerJ, 2018
Background Somatic point substitution mutations in the KRAS proto-oncogene primarily affect codons 12/13 where glycine is converted into other amino acids, and are highly prevalent in pancreatic, colorectal, and non-small cell lung cancers. These cohorts
Allan Wee Ren Ng, Pei Jun Tan, Winfrey Pui Yee Hoo, Dek Shen Liew, Michelle Yee Mun Teo, Pui Yan Siak, Sze Man Ng, Ee Wern Tan, Raha Abdul Rahim, Renee Lay Hong Lim, Adelene Ai Lian Song, Lionel Lian Aun In   +11 more
doaj   +2 more sources