Results 21 to 30 of about 114,349,436 (308)

FVIII Immunogenicity—Bioinformatic Approaches to Evaluate Inhibitor Risk in Non-severe Hemophilia A

Frontiers in Immunology, 2020
The life-long inhibitor risk in non-severe hemophilia A has been an important clinical and research focus in recent years. Non-severe hemophilia A is most commonly caused by point mutation, missense F8 genotypes, of which over 500 variants are described.
Daniel P. Hart
doaj   +1 more source

Evaluation of in silico predictors on short nucleotide variants in HBA1, HBA2, and HBB associated with haemoglobinopathies

eLife, 2022
Haemoglobinopathies are the commonest monogenic diseases worldwide and are caused by variants in the globin gene clusters. With over 2400 variants detected to date, their interpretation using the American College of Medical Genetics and Genomics (ACMG ...
Stella Tamana, Maria Xenophontos, Anna Minaidou, Coralea Stephanou, Cornelis L Harteveld, Celeste Bento, Joanne Traeger-Synodinos, Irene Fylaktou, Norafiza Mohd Yasin, Faidatul Syazlin Abdul Hamid, Ezalia Esa, Hashim Halim-Fikri, Bin Alwi Zilfalil, Andrea C Kakouri, ClinGen Hemoglobinopathy Variant Curation Expert Panel, Marina Kleanthous, Petros Kountouris   +16 more
doaj   +1 more source

In Vitro and In Silico ADME Prediction [PDF]

, 2018
Pharmacokinetic issues have been identified as a major cause for the attrition of new chemical entities in drug discovery. High development costs and time investments are associated with the discovery of such issues during clinical drug development.
Effinger, Angela, O'Driscoll, Caitriona M., McAllister, Mark, Fotaki, Nikoletta; id_orcid 0000-0003-1826-7363   +3 more
openaire   +1 more source

A Computational Workflow to Predict Biological Target Mutations: The Spike Glycoprotein Case Study

Molecules, 2023
The biological target identification process, a pivotal phase in the drug discovery workflow, becomes particularly challenging when mutations affect proteins’ mechanisms of action.
Pietro Cozzini, Federica Agosta, Greta Dolcetti, Alessandro Dal Palù   +3 more
doaj   +1 more source

Review of Immunoinformatic approaches to in-silico B-cell epitope prediction [PDF]

, 2007
In this paper, the current state of in-silico, B-cell epitope prediction is discussed. Recommendations for improving some of the approaches encountered are outlined, along with the presentation of an entirely novel technique, which uses molecular ...
Rick Reitmaier
core   +1 more source

Prediction and Mapping of Potential Bioactive Peptide from Traditional Fermented Anchovy (Rusip) using Bioinformatics Approaches

Squalen, 2023
Bioactive peptides can be obtained from various sources, one of which is a fermented food. Rusip is a traditional Indonesian fermented food made from anchovy (Stolephorus spp.), which has the potential as a source of bioactive peptides.
Muhammad Alfid Kurnianto, Fathma Syahbanu, Hamidatun Hamidatun, Yushinta Aristina Sanjaya   +3 more
doaj   +1 more source

"In silico" prediction of drug transport across physiological barriers [PDF]

, 2011
Physiological barriers maintain and safeguard homeostasis of certain body compartments by an increased resistance against free diffusion. Distribution and pharmacokinetics of drugs can be altered as well, if they have to cross these barriers in order to ...
Suenderhauf, Claudia
core   +1 more source

In silico-guided sequence modifications of K-ras epitopes improve immunological outcome against G12V and G13D mutant KRAS antigens [PDF]

PeerJ, 2018
Background Somatic point substitution mutations in the KRAS proto-oncogene primarily affect codons 12/13 where glycine is converted into other amino acids, and are highly prevalent in pancreatic, colorectal, and non-small cell lung cancers. These cohorts
Allan Wee Ren Ng, Pei Jun Tan, Winfrey Pui Yee Hoo, Dek Shen Liew, Michelle Yee Mun Teo, Pui Yan Siak, Sze Man Ng, Ee Wern Tan, Raha Abdul Rahim, Renee Lay Hong Lim, Adelene Ai Lian Song, Lionel Lian Aun In   +11 more
doaj   +2 more sources

The Journey towards Solubility Assessment of Small Molecules Using HPLC-DAD

Medical Sciences Forum, 2022
In the process of developing bioactive small molecules, solubility determination is a crucial step. Many research papers treating problems related to solubility are published, but none of them fully describes the methods and steps for solubility ...
Nada Hemmani, Anaïs Cacilie Martin, Andy Larivière, Mathis Tresallet, Kensa Tchang, Isabelle Krimm, Marc Le Borgne   +6 more
doaj   +1 more source

Bayesian Markov Random Rield Analysis for Protein Function Prediction Based on Network Data [PDF]

, 2010
Inference of protein functions is one of the most important aims of modern biology. To fully exploit the large volumes of genomic data typically produced in modern-day genomic experiments, automated computational methods for protein function prediction ...
ter Braak, C.J.F., Yiannis A I Kourmpetis, Cajo J F ter Braak, Kourmpetis, Y.I.A., Roeland C H J van Ham, Ham, R.C.H.J., van, Aalt D J van Dijk, van Dijk, A.D.J., Bink, M.C.A.M., van Dijk Aalt D. J., Kourmpetis Yiannis A. I., van Ham Roeland C. H. J., Dijk, A.D.J., van, Bink Marco C. A. M., Braak, C.J.F., ter, Marco C A M Bink, van Ham, R.C.H.J., ter Braak Cajo J. F.   +17 more
core   +2 more sources