Results 21 to 30 of about 228,098 (300)

FVIII Immunogenicity—Bioinformatic Approaches to Evaluate Inhibitor Risk in Non-severe Hemophilia A

Frontiers in Immunology, 2020
The life-long inhibitor risk in non-severe hemophilia A has been an important clinical and research focus in recent years. Non-severe hemophilia A is most commonly caused by point mutation, missense F8 genotypes, of which over 500 variants are described.
Daniel P. Hart
doaj   +1 more source

Combining in silico prediction and ribosome profiling in a genome-wide search for novel putatively coding sORFs [PDF]

, 2013
Background: It was long assumed that proteins are at least 100 amino acids (AAs) long. Moreover, the detection of short translation products (e. g.
Baggerman, Geert, Crappé, Jeroen, Hayakawa, Eisuke, Luyten, Walter, Menschaert, Gerben, Trooskens, Geert, Van Criekinge, Wim   +6 more
core   +2 more sources

NcPred for accurate nuclear protein prediction using n-mer statistics with various classification algorithms [PDF]

, 2011
Prediction of nuclear proteins is one of the major challenges in genome annotation. A method, NcPred is described, for predicting nuclear proteins with higher accuracy exploiting n-mer statistics with different classification algorithms namely ...
A. Ganesh, A. Garg, A. Pierleoni, A. Reinhardt, B. Alberts, B. Chan, B. Mathews, D. Xie, E. Marcotte, G. Hutchinson, H. Bannai, M. Hall, M. Kumar, O. Emanuelson, W. Jassem   +14 more
core   +3 more sources

Molecular analysis of sarcomeric and non-sarcomeric genes in patients with hypertrophic cardiomyopathy. [PDF]

, 2015
Background: Hypertrophic cardiomyopathy (HCM) is a common genetic heart disorder characterized by unexplained left ventricle hypertrophy associated with non-dilated ventricular chambers.
BOTTILLO, IRENE, CAPUTO, VIVIANA, Castori, M, D'ANGELANTONIO, DANIELA, De Bernardo, C, Giannarelli, D, GRAMMATICO, Paola, LIPARI, MARTINA, Majore, S, PAIARDINI, ALESSANDRO, PIZZUTI, Antonio, Re, F, Zachara, E   +12 more
core   +1 more source

Evaluation of in silico predictors on short nucleotide variants in HBA1, HBA2, and HBB associated with haemoglobinopathies

eLife, 2022
Haemoglobinopathies are the commonest monogenic diseases worldwide and are caused by variants in the globin gene clusters. With over 2400 variants detected to date, their interpretation using the American College of Medical Genetics and Genomics (ACMG ...
Stella Tamana, Maria Xenophontos, Anna Minaidou, Coralea Stephanou, Cornelis L Harteveld, Celeste Bento, Joanne Traeger-Synodinos, Irene Fylaktou, Norafiza Mohd Yasin, Faidatul Syazlin Abdul Hamid, Ezalia Esa, Hashim Halim-Fikri, Bin Alwi Zilfalil, Andrea C Kakouri, ClinGen Hemoglobinopathy Variant Curation Expert Panel, Marina Kleanthous, Petros Kountouris   +16 more
doaj   +1 more source

A Computational Workflow to Predict Biological Target Mutations: The Spike Glycoprotein Case Study

Molecules, 2023
The biological target identification process, a pivotal phase in the drug discovery workflow, becomes particularly challenging when mutations affect proteins’ mechanisms of action.
Pietro Cozzini, Federica Agosta, Greta Dolcetti, Alessandro Dal Palù   +3 more
doaj   +1 more source

Continuous glucose monitoring sensors: Past, present and future algorithmic challenges [PDF]

, 2016
Continuous glucose monitoring (CGM) sensors are portable devices that allow measuring and visualizing the glucose concentration in real time almost continuously for several days and are provided with hypo/hyperglycemic alerts and glucose trend ...
Facchinetti, Andrea
core   +2 more sources

Prediction and Mapping of Potential Bioactive Peptide from Traditional Fermented Anchovy (Rusip) using Bioinformatics Approaches

Squalen, 2023
Bioactive peptides can be obtained from various sources, one of which is a fermented food. Rusip is a traditional Indonesian fermented food made from anchovy (Stolephorus spp.), which has the potential as a source of bioactive peptides.
Muhammad Alfid Kurnianto, Fathma Syahbanu, Hamidatun Hamidatun, Yushinta Aristina Sanjaya   +3 more
doaj   +1 more source

In silico-guided sequence modifications of K-ras epitopes improve immunological outcome against G12V and G13D mutant KRAS antigens [PDF]

PeerJ, 2018
Background Somatic point substitution mutations in the KRAS proto-oncogene primarily affect codons 12/13 where glycine is converted into other amino acids, and are highly prevalent in pancreatic, colorectal, and non-small cell lung cancers. These cohorts
Allan Wee Ren Ng, Pei Jun Tan, Winfrey Pui Yee Hoo, Dek Shen Liew, Michelle Yee Mun Teo, Pui Yan Siak, Sze Man Ng, Ee Wern Tan, Raha Abdul Rahim, Renee Lay Hong Lim, Adelene Ai Lian Song, Lionel Lian Aun In   +11 more
doaj   +2 more sources

The Journey towards Solubility Assessment of Small Molecules Using HPLC-DAD

Medical Sciences Forum, 2022
In the process of developing bioactive small molecules, solubility determination is a crucial step. Many research papers treating problems related to solubility are published, but none of them fully describes the methods and steps for solubility ...
Nada Hemmani, Anaïs Cacilie Martin, Andy Larivière, Mathis Tresallet, Kensa Tchang, Isabelle Krimm, Marc Le Borgne   +6 more
doaj   +1 more source