Results 41 to 50 of about 114,349,436 (308)
Structural Comparison of α-agarase (α-AgaD) from Thalassomonas sp. LD5: An in-silico study
Journal of Tropical Life ScienceThe significance of agarase enzymes spans various high-value industries, including food, cosmetics, and medicine. These enzymes play a crucial role in the hydrolysis of agar to produce bioactive oligosaccharides, enabling wide-ranging applications across
Habeebat Adekilekun Oyewusi +5 more
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Frontiers in Physiology, 2022 BackgroundDespite the positive effects of endurance training on the cardiovascular (CV) system, excessive exercise induces not only physiological adaptations but also adverse changes in CV system, including the heart.
Ceren Eyileten +10 more
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In Silico Prediction of Pharmacokinetics Properties
ChemInform, 2006 AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
openaire +2 more sources
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
Comparing Multi-Label Classification Methods for Provisional Biopharmaceutics Class Prediction. [PDF]
, 2014 The biopharmaceutical classification system (BCS) is now well established and utilized for the development and biowaivers of immediate oral dosage forms. The prediction of BCS class can be carried out using multilabel classification.
Taravat Ghafourian +8 more
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Benchmarking in silico Tools for Cysteine pKa Prediction [PDF]
, 2023 Accurate estimation of the pKas of cysteine residues in proteins could inform targeted approaches in hit discovery. The pKa of a targetable cysteine residue in a disease-related protein is an important physiochemical parameter in covalent drug dis ...
Andrei, Golosov +2 more
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Predicting human blood viscosity in silico [PDF]
Proceedings of the National Academy of Sciences, 2011 The viscosity of blood has long been used as an indicator in the understanding and treatment of disease, and the advent of modern viscometers allows its measurement with ever-improving clinical convenience. However, these advances have not been matched by theoretical developments that can yield a quantitative understanding of blood’s microrheology and ...
Dmitry A, Fedosov +4 more
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Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Pharmacology Research & Perspectives, 2020 Drug development is an arduous procedure, necessitating testing the interaction of a large number of potential candidates with potential interacting (macro)molecules.
Athanasios A. Panagiotopoulos +8 more
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Outside the limit: questioning the distance restrictions for cooperative miRNA binding sites
Cellular & Molecular Biology Letters, 2023 Among the concepts in biology that are widely taken granted is a potentiated cooperative effect of multiple miRNAs on the same target. This strong hypothesis contrasts insufficient experimental evidence.
Caroline Diener +9 more
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