Results 61 to 70 of about 123,989 (167)

Prediction of bioactive compounds hepatotoxicity using in silico and in vitro analysis

Applied Biological Chemistry
The leading safety issue and side effect associated with natural herb products is drug-induced liver injury (DILI) caused by bioactive compounds derived from the herb products.
Kwanyong Choi, Soyeon Lee, Sunyong Yoo, Hyoung-Yun Han, Soo-yeon Park, Ji Yeon Kim   +5 more
doaj   +1 more source

A single point mutation on FLT3L-Fc protein increases the risk of immunogenicity

Frontiers in Immunology
IntroductionAs a crucial asset for human health and modern medicine, an increasing number of biotherapeutics are entering the clinic. However, due to their complexity, these drugs have a higher potential to be immunogenic, leading to the generation of ...
Dan Qin, Qui Phung, Patrick Wu, Zhaojun Yin, Sien Tam, Peter Tran, Adel M. ElSohly, Joshua Gober, Zicheng Hu, Zhenru Zhou, Sivan Cohen, Dongping He, Travis W. Bainbridge, Christopher C. Kemball, Jonathan Zarzar, Alavattam Sreedhara, Nicole Stephens, Jérémie Decalf, Christine Moussion, Zhengmao Ye, Mercedesz Balazs, Yinyin Li   +21 more
doaj   +1 more source

Integrative Analysis of Metabolome and Proteome in the Cerebrospinal Fluid of Patients with Multiple System Atrophy

Cells
Multiple system atrophy (MSA) is a progressive neurodegenerative synucleinopathy. Differentiating MSA from other synucleinopathies, especially in the early stages, is challenging because of its overlapping symptoms with other forms of Parkinsonism. Thus,
Nimisha Pradeep George, Minjun Kwon, Yong Eun Jang, Seok Gi Kim, Ji Su Hwang, Sang Seop Lee, Gwang Lee   +6 more
doaj   +1 more source

Patient-Specific In Silico Prediction of Outcomes of Partial Continuous-Flow LVAD Treatment in Peripartum Cardiomyopathy. [PDF]

Int J Numer Method Biomed Eng
Nagawa J, Sack KL, Nchejane NJ, Motchon YD, Sirry MS, Kraus S, Davies NH, Ntusi NAB, Franz T.   +8 more
europepmc   +1 more source

In Silico Prediction and Validation of the Permeability of Small Molecules Across the Blood-Brain Barrier. [PDF]

Int J Mol Sci
Ajao F, de Jong-Hoogland D, Ulmschneider JP, Ulmschneider MB, Lambden E.   +4 more
europepmc   +1 more source

Recognition of a Critical Functional Domain and Improved <i>PHOX2B</i> Missense Variant Interpretation by Utilization of In Silico Prediction Tools. [PDF]

Hum Mutat
Drackley A, Skol AD, Rand CM, Weese-Mayer DE, Yap KL.   +4 more
europepmc   +1 more source

Outer membrane protein LipL21 as a potential candidate against Leptospira interrogans: An in silico prediction. [PDF]

Indian J Pharmacol
Kumari A, Toor D.
europepmc   +1 more source

In silico prediction of bioequivalence of atorvastatin tablets based on GastroPlus™ software. [PDF]

BMC Pharmacol Toxicol, 2023
Wang L, Chen J, Chen W, Ruan Z, Lou H, Yang D, Jiang B.   +6 more
europepmc   +1 more source

In silico prediction of optimal multifactorial intervention in chronic kidney disease. [PDF]

J Transl Med
Latosinska A, Mina IK, Nguyen TMN, Golovko I, Keller F, Mayer G, Rossing P, Staessen JA, Delles C, Beige J, Glorieux G, Clark AL, Schanstra JP, Vlahou A, Peter K, Rychlík I, Ortiz A, Campbell A, Rupprecht H, Persson F, Mischak H, Siwy J.   +21 more
europepmc   +1 more source

Translational MicroRNA research in COVID-19: bridging in Silico prediction with clinical biomarker potential. [PDF]

Clin Exp Med
El Sharkawi FZ, Mohamed MA, Montasser K, Mahdi MM, Atya HB.   +4 more
europepmc   +1 more source