Results 51 to 60 of about 114,349,436 (308)
The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers
Molecular Oncology, EarlyView.The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce +11 more
wiley +1 more source
Molecular Oncology, EarlyView.RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner +14 more
wiley +1 more source
An empirical evaluation of the effectiveness of different types of predictor attributes in protein function prediction. [PDF]
, 2009 Many classification schemes for defining protein functions, such as Gene Ontology (GO), are organised in a hierarchical structure. Nodes near the root of the hierarchy represent general functions while nodes near the leaves of the hierarchy represent ...
Segond, Marc +11 more
core +1 more source
BMC Genomics, 2021 Background The phytopatogen Claviceps paspali is the causal agent of Ergot disease in Paspalum spp., which includes highly productive forage grasses such as P. dilatatum.
H. Oberti +6 more
doaj +1 more source
In silico prediction of endocrine activity
Trends in Endocrinology & MetabolismEndocrine-disrupting chemicals (EDCs) pose health risks; yet, conventional in vitro and in vivo testing remains slow, costly, and animal-intensive. Enhanced use of in silico approaches can contribute to earlier and increased detection of potential EDCs.
Daan A. Jiskoot +5 more
openaire +4 more sources
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
mAbsIn silico assessment of antibody developability during early lead candidate selection and optimization is of paramount importance, offering a rapid and material-free screening approach.
Eliott Park, Saeed Izadi
doaj +1 more source
Individual HLA-A, -B, -C, and -DRB1 Genotypes Are No Major Factors Which Determine COVID-19 Severity
Frontiers in Immunology, 2021 HLA molecules are key restrictive elements to present intracellular antigens at the crossroads of an effective T-cell response against SARS-CoV-2. To determine the impact of the HLA genotype on the severity of SARS-CoV-2 courses, we investigated data ...
Johannes Schetelig +26 more
doaj +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
A systematic review of computational simulation methods for predicting the toxicity of chemical compounds [PDF]
بهداشت و ایمنی کارIntroduction: With the rapid development of new chemicals across various industries and the growing need for efficient and accurate toxicity assessments, in silico methods have emerged as a screening tool due to their cost-effectiveness, time efficiency,
Akram Tabrizi +3 more
doaj