Results 51 to 60 of about 228,098 (300)

Genome-wide analysis of Claviceps paspali: insights into the secretome of the main species causing ergot disease in Paspalum spp

BMC Genomics, 2021
Background The phytopatogen Claviceps paspali is the causal agent of Ergot disease in Paspalum spp., which includes highly productive forage grasses such as P. dilatatum.
H. Oberti, G. Spangenberg, N. Cogan, R. Reyno, M. Feijoo, S. Murchio, M. Dalla-Rizza   +6 more
doaj   +1 more source

Formulation pre-screening of inhalation powders using computational atom-atom systematic search method [PDF]

, 2014
This is an open access article published under a Creative Commons Attribution (CC-BY) License, which permits unrestricted use, distribution and reproduction in any medium, provided the author and source are cited.The synthonic modeling approach provides ...
Collins, Elizabeth, Forbes, Ben, Hammond, Robert B., Jaffari, Sara, Martin, Gary P., Murnane, Darragh, Pencheva, Klimentina, Pickering, Jonathan, Ramachandran, Vasuki, Roberts, Kevin J., Soufian, Majeed   +10 more
core   +4 more sources

Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma

Molecular Oncology, EarlyView.
Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra, Lucca Paolo Hsu Helmich, Daniel Rodrigues de Bastos, Laura Sichero, Patrícia Savio de Araujo‐Souza, Fabio Passetti, Luisa Lina Villa   +6 more
wiley   +1 more source

Engineering miRNA features into siRNAs: Guide-strand bulges are compatible with gene repression

Molecular Therapy: Nucleic Acids, 2022
Synthetic siRNA guide strands are typically designed with perfect complementarity to the passenger strand and the target mRNA. We examined whether siRNAs with intentional guide-strand bulges are functional in vitro and in vivo. Importantly, this was done
Judith Hauptmann, Vivien Hehne, Melanie Balzer, Lucas Bethge, Marie Wikstrom Lindholm   +4 more
doaj   +1 more source

New Synthetic Cannabinoids Metabolism and Strategies to Best Identify Optimal Marker Metabolites. [PDF]

, 2019
Synthetic cannabinoids (SCs) were initially developed as pharmacological tools to probe the endocannabinoid system and as novel pharmacotherapies, but are now highly abused.
Diao, Xingxing, Huestis, Marilyn A.
core   +2 more sources

A single polyploidization event at the origin of the tetraploid genome of Coffea arabica is responsible for the extremely low genetic variation in wild and cultivated germplasm [PDF]

, 2020
The genome of the allotetraploid species Coffea arabica L. was sequenced to assemble independently the two component subgenomes (putatively deriving from C. canephora and C.
Al Hakimi, Amin, Bentley, Nolan, Bertrand, Benoît, Cattonaro, Frederica, Cerutti, Mario, Del Terra, Lorenzo, Di Gaspero, Gabriele, Graziosi, Giorgio, Jurman, Irena, Klein, Patricia E., Magni, Federica, Magris, Gabriele, Montagnon, Christophe, Morgante, Michele, Murray, Seth C., Navarini, Luciano, Pallavicini, Alberto, Pellegrino, Gloria, Pinosio, Sara, Ruosi, Manuela Rosanna, Scaglione, Davide, Scalabrin, Simone, Schilling, Timothy, Solano, William, Suggi Liverani, Furio, Toniutti, Lucile, Valle, Giorgio, Vidotto, Michele, Vitulo, Nicola   +28 more
core   +3 more sources

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Molecular surface descriptors to predict antibody developability: sensitivity to parameters, structure models, and conformational sampling

mAbs
In silico assessment of antibody developability during early lead candidate selection and optimization is of paramount importance, offering a rapid and material-free screening approach.
Eliott Park, Saeed Izadi
doaj   +1 more source

D-CyPre: a machine learning-based tool for accurate prediction of human CYP450 enzyme metabolic sites [PDF]

PeerJ Computer Science
The advancement of graph neural networks (GNNs) has made it possible to accurately predict metabolic sites. Despite the combination of GNNs with XGBOOST showing impressive performance, this technology has not yet been applied in the realm of metabolic ...
Haolan Yang, Jie Liu, Kui Chen, Shiyu Cong, Shengnan Cai, Yueting Li, Zhixin Jia, Hao Wu, Tianyu Lou, Zuying Wei, Xiaoqin Yang, Hongbin Xiao   +11 more
doaj   +2 more sources

N-terminal proteomics assisted profiling of the unexplored translation initiation landscape in Arabidopsis thaliana [PDF]

, 2017
Proteogenomics is an emerging research field yet lacking a uniform method of analysis. Proteogenomic studies in which N-terminal proteomics and ribosome profiling are combined, suggest that a high number of protein start sites are currently missing in ...
Gevaert, Kris, Jonckheere, Veronique, Martens, Lennart, Ndah, Elvis, Stael, Simon, Sticker, Adriaan, Van Breusegem, Frank, Van Damme, Petra, Willems, Patrick   +8 more
core   +1 more source