Results 91 to 100 of about 32,158 (205)

Respiratory Syncytial Virus Under the Lens of Structure: From Prefusion Stabilization to Next‐Generation Immunotherapies

iNew Medicine, EarlyView.
This illustration integrates key concepts covered in the review, including high‐risk populations, viral structure, host entry factors, the replication cycle, and licensed antibody‐based prevention strategies. ABSTRACT Respiratory syncytial virus (RSV) is a negative‐sense RNA virus belonging to the genus Orthopneumovirus within the family Pneumoviridae.
Zekai Cheng, Qianqian Wang, Jiachen Zhang, Sandra Chiu   +3 more
wiley   +1 more source

Osteoporosis Is Characterized by Altered Expression of Exosomal Long Non-coding RNAs

Frontiers in Genetics, 2020
Osteoporosis is a metabolic bone disease characterized by a decrease in bone mass and degradation of the bone microstructure, which increases bone fragility and risk of fracture. However, the molecular mechanisms of osteoporosis remain unclear.
Zhaowei Teng, Zhaowei Teng, Zhaowei Teng, Yun Zhu, Xiguang Zhang, Yirong Teng, Sheng Lu   +6 more
doaj   +1 more source

Proteomics of Nitrotyrosine: Integrating Mass Spectrometry and Immunodetection in Redox‐Driven Pathology

Mass Spectrometry Reviews, EarlyView.
ABSTRACT Nitrooxidative stress, driven by excess reactive nitrogen species like peroxynitrite, contributes to the pathogenesis of many chronic diseases. Among its molecular footprints, 3‐nitrotyrosine (3NT) has emerged as a biologically relevant marker of protein nitration.
Brîndușa Alina Petre
wiley   +1 more source

Functional characterization and structure-guided mutational analysis of the transsulfuration enzyme cystathionine γ-lyase from toxoplasma gondii [PDF]

, 2018
Sulfur-containing amino acids play essential roles in many organisms. The protozoan parasite Toxoplasma gondii includes the genes for cystathionine β-synthase and cystathionine γ-lyase (TgCGL), as well as for cysteine synthase, which are crucial enzymes ...
Astegno, A., Dominici, P, Fruncillo, S, Janson, G, Maresi, E, Paiardini, A, Vallone, R   +6 more
core   +2 more sources

Peptidic product derived from trypsin autolysis modulates insect digestive proteases and supports plant biochemical defense

Pest Management Science, EarlyView.
XXXX Abstract BACKGROUND Spodoptera frugiperda, commonly known as the fall armyworm, is a highly economically significant pest that affects various crops, resulting in substantial losses in productivity. Managing this pest primarily relies on chemical insecticides; however, the repeated development of resistance to these chemicals has rendered them ...
Daniel Guimarães Silva Paulo, Halina Schultz, Yaremis Beatriz Meriño Cabrera, Ian Lucas Batista Santos, Maria Clara Neves Gomes Rodrigues, Milena Godoi Lima, Geisiane Aparecida Mariano, Rafael Junior de Andrade, Humberto Josué de Oliveira Ramos, Maria Goreti de Almeida Oliveira   +9 more
wiley   +1 more source

Auxin and epigenetic regulation of SKP2B, an F-box that represses lateral root formation [PDF]

, 2012
In plants, lateral roots originate from pericycle founder cells that are specified at regular intervals along the main root. Here, we show that Arabidopsis (Arabidopsis thaliana) SKP2B (for S-Phase Kinase-Associated Protein2B), an F-box protein ...
Beeckman, Tom, Casero, Pedro, Casimiro, Ilda, De Rybel, Bert, del Pozo, Juan C, Desvoyes, Bénédicte, Gutierrez, Crisanto, Manzano, Concepción, Otero, Sofía, Ramirez-Parra, Elena   +9 more
core   +2 more sources

Lecanicillium aphanocladii: a biocontrol agent against insect pests and phytopathogens

Pest Management Science, EarlyView.
Recent research findings on the biocontrol potential of Lecanicillium aphanocladii fungus against insect‐pests and plant diseases were highlighted. This review indicates that several L. aphanocladii strains show great potential to be developed as multipurpose biocontrol agents active against several insect‐pests, plant diseases and plant parasitic ...
Qianhe Liu, Richard Johnson, Kwasi Adusei‐Fosu   +2 more
wiley   +1 more source

Microarray evidence for off target effects in tick RNA interference experiments, and the lack of strong correlation between DSRNA and antibody phenotypes in tick In vitro treatments for vaccine candidate screening [PDF]

, 2011
No abstract ...
Barrero, R., Bellgard, M.I., Bruyeres, A.B., Gondro, C., Kurscheid, S., Lew-Tabor, A., Moolhuijzen, P.M., Morgan, J.A.T., Rodriguez-Valle, M., Zhang, B.   +9 more
core   +1 more source

From Membrane Composition to Antimicrobial Strategies: Experimental and Computational Approaches to AMP Design and Selectivity

Small, EarlyView.
Antimicrobial peptides (AMPs) are promising candidates for next‐generation antibiotics, acting through mechanisms such as membrane disruption and intracellular targeting. This review examines how variations in bacterial membrane composition critically influence AMP activity.
Paolo Rossetti, Marius F.W. Trollmann, Christina Wichmann, Thomas Gutsmann, Christian Eggeling, Rainer A. Böckmann   +5 more
wiley   +1 more source

Chemoproteomics Reveals USP5 (Ubiquitin Carboxyl-Terminal Hydrolase 5) as Promising Target of the Marine Polyketide Gracilioether A

Marine Drugs
Mass spectrometry-based chemical proteomic approaches using limited proteolysis have become a powerful tool for the identification and analysis of the interactions between a small molecule (SM) and its protein target(s).
Alessandra Capuano, Gilda D’Urso, Michela Aliberti, Dafne Ruggiero, Stefania Terracciano, Carmen Festa, Alessandra Tosco, Maria Giovanna Chini, Gianluigi Lauro, Giuseppe Bifulco, Agostino Casapullo   +10 more
doaj   +1 more source