Results 101 to 110 of about 117,925,879 (224)

Pharmacokinetic and Pharmacodynamic Interactions Between Anti‐Asthma Drugs and Medicinal Plants: A Comprehensive Review

Phytotherapy Research, EarlyView.
ABSTRACT Asthma affects 260–300 million people worldwide. About 20%–35% of patients use medicinal plants with their asthma medication, often without telling their clinicians. Disclosure rates are low; up to 42% of asthma outpatients use herbal products, with no records in their charts.
Emine Kocyigit, Aylin Bülbül, Betul Kocaadam‐Bozkurt, Osman Bozkurt, Duygu Ağagündüz, Raffaele Capasso   +5 more
wiley   +1 more source

Notoginsenoside R2 Antagonizes Renal Interstitial Fibrosis by Regulating Fatty Acid Oxidation via the CASP2/ALDH3A1 Axis

Phytotherapy Research, EarlyView.
Proposed mechanism by which notoginsenoside R2 (NGR2) attenuates renal interstitial fibrosis. In injured renal tubular epithelial cells, CASP2 downregulation and enhanced ubiquitin‐dependent degradation of ALDH3A1 disrupt mitochondria‐associated endoplasmic reticulum membranes (MAMs) and impair fatty acid oxidation (FAO), leading to lipid accumulation ...
Guanting Chen, Tao Li, Zhenzhen Wang, Hao Zhao, Xiaoxia Xun, Yijiao Wang, Shiyuan Jiang, Qing Zhang, Weiwei Sun, Kang Yang, Yaoxian Wang   +10 more
wiley   +1 more source

A Serum‐Resistant Plasma Membrane Probe for Real‐Time Visualization of Pathogen‐Induced Epithelial Barrier Dysfunction

Small, EarlyView.
PM580 selectively activates at the plasma membrane while remaining minimally responsive to serum albumin, enabling serum‐compatible, surface‐confined imaging for 24 h, unlike conventional probes that rapidly internalize and lose membrane contrast.
Yujeong Choi, Sunhwa Jung, Dong Min Kang, Lizaveta Gotina, Minji Kim, Eunmi Ha, Sungsu Lim, Ae Nim Pae, Jaeson Jang, Evgeni Ponimaskin, Ja‐Hyun Baik, Sun‐Joon Min, Yun Kyung Kim   +12 more
wiley   +1 more source

Artificial intelligence empowers targeted protein degradation: Core technological innovations, multi‐scenario applications, and translational prospects

Smart Molecules, EarlyView.
AI is transforming TPD by improving the design, prediction, and optimization of degraders such as PROTACs, molecular glues, and LYTACs. This review summarizes key AI‐driven advances, highlights applications across drug discovery stages, and discusses remaining challenges and future directions for accelerating the development of therapies against ...
Shuanglin Qin, Rui Peng, Guangshuai Zhang, Si Yan, Jin Xiao, Zishu Liu, Ziyu Tan, Qingqing Xie, Shangjie Li, Wei Luo, Xiaohe Xiao   +10 more
wiley   +1 more source

Analysis and Control of Proteolysis of Recombinant Proteins in Escherichia coli

, 2004
Proteolysis is one of the reasons for poor production of recombinant proteins in Escherichia coli. Important properties of E. coli proteases, which are relevant for the production of recombinant proteins, are reviewed.
Rozkov, Aleksei D.,, Sven-Olof Enfors, Aleksei Rozkov, Enfors, Sven-Olof,   +3 more
core   +1 more source

Structural themes of cereblon‐recruiting degraders: selected recent examples

Acta Crystallographica Section F, EarlyView.
Structural studies of cereblon‐recruiting degrader complexes have transformed our understanding of targeted protein degradation. This review discusses selected examples of how X‐ray crystallography and cryogenic‐electron microscopy have enabled the structure‐guided optimization of heterobifunctional degraders and molecular‐glue degraders.
Sana Ahmed, Michael Rowley
wiley   +1 more source

The nitty‐gritty of vascular permeability in cancer: targeting blood endothelium to control metastases

British Journal of Pharmacology, EarlyView.
Blood vascular permeability is a hallmark of cancer and acts as an active driver of metastatic dissemination. Metastasis accounts for the vast majority of cancer deaths, yet most work has focussed on tumour‐intrinsic traits and angiogenesis, while the specific contribution of endothelial barrier regulation to intravasation and extravasation remains ...
Pierre Boucher, Mérone Da Costa Oliveira, Adrien Levesque, Alexandre Rutault, Patrick Savoyaud, Nicolas Bréchot, Stéphane Germain   +6 more
wiley   +1 more source

Natural product‐derived TRPM7 channel inhibitors in neurological injury: Mechanisms, pharmacological potential and translational challenges

British Journal of Pharmacology, EarlyView.
Disruption of intracellular ionic homeostasis is a convergent pathological feature across diverse neurological injuries and disorders, including ischaemic and haemorrhagic stroke, hypoxic–ischaemic brain injury, traumatic brain injury, epilepsy and brain tumour.
Xinyang Zhang, Hio Lam Ho, F. David Horgen, Andrea Fleig, Zhong‐Ping Feng, Hong‐Shuo Sun   +5 more
wiley   +1 more source

A novel ACE inhibitory peptide from Pelodiscus sinensis Wiegmann meat water-soluble protein hydrolysate

Amino Acids
Pelodiscus sinensis meat is a nutritional food and tonic with angiotensin-converting enzyme (ACE) inhibitory activities. To identify the bioactive substances responsible, several bioinformatics methods were integrated to enable a virtual screening for ...
Pengying Liao, Huayu Liu, Xueqin Sun, Xinrui Zhang, Miao Zhang, Xianyou Wang, Jun Chen   +6 more
doaj   +1 more source

Virtual screening and directional preparation of xanthine oxidase inhibitory peptides derived from hemp seed protein

Food Science and Human Wellness
The traditional nutritional and medical hemp (Cannabis sativa L.) seed protein were explored for the discovery and directional preparation of new xanthine oxidase inhibitory (XOI) peptides by structure-based virtual screening, compound synthesis, in ...
Xiaoni Huang, Jiajun Liao, Ping Shi, Xiaodong Pei, Chenghua Wang   +4 more
doaj   +1 more source