Results 111 to 120 of about 117,925,879 (224)

Dataset 6 - Consensus Non-Haemolytic Antimicrobial Peptides Identified By Three Prediction Models (HemoPi, Macrel and MQSSM) From Peptidomes Derived From Cnidaria Omics Data

Consensus approach using three prediction models (HemoPi, Macrel and MQSSM) to identify putative non-haemolytic antimicrobial peptides from peptidomes generated by in silico proteolysis of Cnidaria omics ...
Barroso, Alexandre
core   +1 more source

The lowdown on breakdown: Open questions in plant proteolysis [PDF]

Proteolysis, including post-translational proteolytic processing as well as protein degradation and amino acid recycling, is an essential component of the growth and development of living organisms.
Theodoulou, F. L., Genschik, Pascal, Schnittger, A., Schaller, Andreas, Eckardt, N. A., Serino, G., Noir, S., Chen, Qian, Xie, Q., Rodriguez, Pedro L, Chen, Poyu, Wittenberg, T. A., Noir, Sandra, Theodoulou, Frederica L, Zhang, H., Gibbs, D. J., Serino, Giovanna, Üstün, Suayib, Murcha, M. W., Mursalimov, S., Chen, Q., Heese, Maren, Stintzi, Annick, Fang, Jun, Fang, J., Guercio, Angelica M, Chen, P., Schaller, A., Wei, N., Yu, F., Palayam, M., Peixoto, Bruno, Wei, Ning, Peixoto, B., van Wijk, K. J., Rodriguez, P. L., Michaeli, S., Gibbs, Daniel J, Genschik, P., Mursalimov, Sergey, Xie, Qi, Guercio, A. M., Shabek, Nitzan, Murcha, Monika W., Jarvis, R Paul, Ghifari, Abi S, van Wijk, Klaas J, Stintzi, A., Murcha, Monika W, Heese, M., Zhang, Hongtao, Gibbs, Daniel; id_orcid, Palayam, Malathy, Jarvis, R. P., Schnittger, Arp, Yu, Feifei, Üstün, S., Avin-Wittenberg, Tamar, Shabek, N., Bassham, Diane C, Ghifari, A. S., Michaeli, Simon, Bassham, D. C., Eckardt, Nancy A, Wei, N, Heese, M. (Maren), Murcha, M. (Monika W), Michaeli, S. (Simon), Mursalimov, S, Theodoulou, Frederica, L, Theodoulou, F. (Frederica L), van Wijk, K. (Klaas J), Rodriguez Egea, Pedro Luis, Murcha, Monika, W, Rodriguez, Pedro, L, Schnittger, A, Jarvis, R, Paul, Zhang, H. (Hongtao), Palayam, M. (Malathy), Guercio, A. (Angelica M), Chen, P. (Poyu), Stintzi, A, Xie, Q, Murcha, M.W., Michaeli, S, Peixoto, B. (Bruno), Jarvis, R. (R Paul), Guercio, A.M, Wei, N. (Ning), Bassham, D. (Diane C), Eckardt, N.A, Ghifari, A.S, Bassham, D.C, Stintzi, A. (Annick), Genschik, P. (Pascal), Genschik, P, Zhang, H, Serino, G. (Giovanna), Yu, F, Serino, G, Gibbs, Daniel, J, Guercio, Angelica, M, Bassham, Diane, C, Schaller, A. (Andreas), Fang, J. (Jun), Gibbs, D.J, Mursalimov, S. (Sergey), Ghifari, Abi, S, Avin-Wittenberg, T. (Tamar), Schaller, A, Noir, S. (Sandra), Fang, J, van Wijk, Klaas, J, Rodriguez, P. (Pedro L), Shabek, N, van Wijk, K.J, Eckardt, N. (Nancy A), Chen, Q. (Qian), Xie, Q. (Qi), Avin-Wittenberg, T., Theodoulou, F.L, Peixoto, B, Chen, P, Gibbs, D. (Daniel J), Heese, M, Noir, S, Üstün, S, Üstün, S. (Suayib), Eckardt, Nancy, A, Ghifari, A. (Abi S), Jarvis, R.P., Yu, F. (Feifei), Schnittger, A. (Arp), Shabek, N. (Nitzan)   +133 more
core   +1 more source

PEG400 regulates Falcipain 2 activity through an allosteric mechanism

The FEBS Journal, EarlyView.
Falcipain‐2 can potentially be leveraged as a drug target due to its critical role as a haemoglobinase during the intra‐erythrocytic stage of Plasmodium falciparum. Here, we investigate the regulation of the proteolytic and haemoglobinase activity of falcipain‐2 in the presence of polyethylene glycol.
Bikram Nath, Subhoja Chakraborty, Sampa Biswas   +2 more
wiley   +1 more source

A novel rare splice variant of the human voltage‐dependent proton channel hHV1

The FEBS Journal, EarlyView.
Alternative splicing of the human HVCN1 gene produces a rare, very‐long proton channel isoform (hHV1‐vl) containing an additional 47 amino acids at its N terminus. This variant was detected in human tissues, including choroid plexus epithelial cells and lymphomas. Compared with the conventional long isoform (hHV1‐l), hHV1‐vl activates more slowly while
Gustavo Chaves, Karl‐Matthäus C. Herold, Christian Derst, Christophe Jardin, Iryna Mahorivska, Carolin S. Jäger, Arne Franzen, Boris Musset   +7 more
wiley   +1 more source

Dataset 5 - Consensus Antimicrobial Peptides Identified By Three Prediction Models (AMPir, AMPlify and Macrel) From Peptidomes Derived From Cnidaria Omics Data

Consensus approach using three prediction models (AMPir, AMPlify and Macrel) to identify putative antimicrobial peptides from peptidomes generated by in silico proteolysis of Cnidaria omics ...
Barroso, Alexandre
core   +1 more source

Saliva Liquid Biopsy for Detection of Oral and Systemic Diseases

Journal of Periodontal Research, EarlyView.
This Review summarizes and discusses the biological foundations and major classes of salivary biomarkers, outlines collection methods and analytical protocols for saliva‐based liquid biopsy, and technological convergences driven by multi‐omics approaches, artificial intelligence, and point‐of‐care devices in the application of oral and systemic ...
Irene Choi, Aaron Zander, Bradley Chan, Leila Syedmoradi, Dev Trivedi, Karolina Elżbieta Kaczor‐Urbanowicz, Fang Wei, Neeti Swarup, Trinity Chan, Mario Romandini, David T. W. Wong   +10 more
wiley   +1 more source

Data quality assessment for in silico methods: A survey of approaches and needs

, 2010
As indicated in Chapter 3, there are a large number of potential sources of data now available for modelling purposes. These range from historical literature references for a few compounds to highly curated databases of hundreds of thousands of compounds,
Fernandez, A., Vemeire, T., Nendza, M., I. Mangelsdorf, S. Jeram, M.T.D. Cronin, D. Kroese, Rallo, R., A. Fernandez, A. Roncaglioni, S. Escher, Hewitt, M., Madden, J., Mangelsdorf, I., Roncaglioni, A., Escher, S., Aldenberg, T., M. Hewitt, Cronin, M., Hrovat, M., E. Benfenati, T. Vermeire, Kroese, D., M. Nendza, H. Segner, Rorije, E., T. Aldenberg, Gabbert, S.G.M., Giralt, F., J. C. Madden, B. Simon-Hettich, E. Rorije, F. Giralt, M. Hrovat, Segner, H., R. Benigni, Jeram, S., Benigni, R., R. Rallo, S. Gabbert, Simon-Hettich, B., Benfenati, E., Madden, J.C., Cronin, M.T.D., Gabbert, S., Vermeire, T.G.   +45 more
core   +1 more source

Preclinical Target Animal Safety Evaluation of Veterinary Monoclonal Antibodies: Principles, Methods, and Interpretation

Journal of Veterinary Pharmacology and Therapeutics, EarlyView.
ABSTRACT Monoclonal antibodies (mAbs) represent a rapidly expanding pharmaceutical class in veterinary medicine, with several products now authorized for use in dogs and cats. Limited published articles and veterinarian exposure to the principles of drug development present challenges in interpreting published safety evaluations that inform product ...
Adam Werts, Matthew Kuhn, Lauren Bessey, Alicia Braxton Hickman, Emily Chory, John Mitchell, Kirby Pasloske   +6 more
wiley   +1 more source

Antioxidant supplementation blunts the proteome response to 3 weeks of sprint interval training preferentially in human type 2 muscle fibres

The Journal of Physiology, EarlyView.
Abstract figure legend Sprint interval training (SIT) is a popular time‐efficient type of endurance training. Healthy young men performed nine SIT sessions (4–6 × 30 s all‐out cycling sprints) over 3 weeks while being supplemented with antioxidants (high doses of vitamins C and E) or placebo. Muscle biopsies taken before and after the first SIT session
Victoria L. Wyckelsma, Marta Murgia, Sigitas Kamandulis, Stefano Gastaldello, Marius Brazaitis, Audrius Snieckus, Nerijus Eimantas, Mati Pääsuke, Sebastian Edman, William Apro, Daniel C. Andersson, Håkan Westerblad, Tomas Venckunas   +12 more
wiley   +1 more source

Identification and Sensory Characterization of Umami Peptides During Lager Beer Fermentation

Foods
Despite increasing interest in beer-derived umami peptides, their formation during lager beer fermentation and their potential roles in receptor recognition and sensory perception remain insufficiently understood.
Yashuai Wu, Wenjing Tian, Wanqiu Zhao, Jiayang Luo, Xin Yuan, Jiang Xie, Bofeng Zhong, Dongrui Zhao   +7 more
doaj   +1 more source