Results 131 to 140 of about 16,993 (213)

De Novo Design and Directed Evolution Refinement of Mirror‐Image Protein Binders Targeting Interleukin‐4

Advanced Science, Volume 13, Issue 32, 9 June 2026.
This study presents the de novo design and directed evolution of a mirror‐image D‐protein inhibitor targeting human interleukin‐4 (IL‐4). The engineered molecule exhibits nanomolar binding affinity for IL‐4 and effectively inhibits IL‐4–mediated signaling.
Liqing Xu, Yuxiang Ren, Tongyue Wang, Hongyong Li, Yue Yao, Lei Liu, Ke Sun, Peilong Lu   +7 more
wiley   +1 more source

Defensin‐DNA Supramolecular Complexes as a New pH‐Sensing Nanomaterial

Aggregate, Volume 7, Issue 6, June 2026.
Crocodylus porosus β‐defensin 13 (CpoBD13), a host defence peptide from the saltwater crocodile, is discovered to interact with single‐ and double‐stranded DNA to form supramolecular assemblies, termed defensin‐induced spherical complexes (DISCs).
Scott A. Williams, Serenay B. Demir, Dilara C. Ozkocak, Michael A. Harris, Ira Ghosh, Matthew J. A. Hein, Stephanie F. Rutter, Gavan J. Francis, Christine J. Hawkins, Ivan K. H. Poon, Thanh Kha Phan, Nicholas P. Reynolds, Adam Mechler, Kazuhide S. Okuda, Marc Kvansakul, Mark D. Hulett   +15 more
wiley   +1 more source

Integrative genomic and functional characterization of ADAMTS3 reveals its inflammatory regulation via NF‐κB and STAT3 pathways in osteosarcoma

Journal of Cell Communication and Signaling, Volume 20, Issue 2, June 2026.
Abstract Osteosarcoma (OS) is an aggressive bone malignancy characterized by genomic instability and extensive extracellular matrix (ECM) remodeling. Members of the ADAMTS family are matrix‐associated proteases implicated in tumorigenesis; however, their roles in OS remain poorly defined. This study provides a comprehensive genomic, transcriptomic, and
Ehed Muhammed Aymaz, Meltem Alper, Feyza Nur Sav, Tuğşen Aydemir, Feray Köçkar   +4 more
wiley   +1 more source

Single‐cell and repertoire profiling reveals immune remodelling in paediatric upper airway: insights from adenoid hypertrophy

Clinical &Translational Immunology, Volume 15, Issue 6, 2026.
Single‐cell and paired V(D)J profiling show that paediatric adenoid hypertrophy features expanded proliferative germinal‐centre B cells with impaired maturation. Abstract Objectives To characterise the immune cellular landscape and paired B‐cell and T‐cell receptor repertoires of hypertrophic adenoids in children with obstructive sleep apnoea.
Chao Wang, Yufei Pan, Xiao Han, Kai Sun, Jing Li, Yuanyuan Lu, Zhenkun Yu   +6 more
wiley   +1 more source

Respiratory Syncytial Virus Under the Lens of Structure: From Prefusion Stabilization to Next‐Generation Immunotherapies

iNew Medicine, Volume 2, Issue 2, June 2026.
This illustration integrates key concepts covered in the review, including high‐risk populations, viral structure, host entry factors, the replication cycle, and licensed antibody‐based prevention strategies. ABSTRACT Respiratory syncytial virus (RSV) is a negative‐sense RNA virus belonging to the genus Orthopneumovirus within the family Pneumoviridae.
Zekai Cheng, Qianqian Wang, Jiachen Zhang, Sandra Chiu   +3 more
wiley   +1 more source

In Silico and In Vitro Screening and Mechanisms of Angiotensin I-Converting Enzyme Inhibitory Peptides from Protein Hydrolysates of Royal Jelly. [PDF]

Foods
Zhang Y, Guo S, Miao H, Gu Y, Zhang J.
europepmc   +1 more source

Production of Multiple Variants of the Antimicrobial Sactipeptide Gnavucin D by the Human Gut Isolate Mediterraneibacter gnavus HB038

MicrobiologyOpen, Volume 15, Issue 3, June 2026.
Gnavucin D, a novel antibacterial sactipeptide produced by Mediterraneibacter gnavus HB038, exhibits activity against multiple pathogens, including Clostridium perfringens, Streptococcus agalactiae, Bacillus cereus, and vancomycin‐resistant Enterococcus.
Mengfan Ding, Felipe Miceli de Farias, Paula M. O'Connor, Xiaohui Huang, Fiona C. Ross, Elaine C. Kennedy, Colin P. Hawkes, Colin Hill, Catherine Stanton, Reynolds Paul Ross   +9 more
wiley   +1 more source

<i>In Silico</i> Structural Characterization and Hypoglycemic Potential of a Novel Fucose-Specific Lectin (MEP5) from <i>Morchella esculenta</i>. [PDF]

Foods
Chen W, Liu P, Li W, Wu D, Zhang Z, Yang Y.   +5 more
europepmc   +1 more source

Progress in Natural Products Target Discovery Technology

MedComm, Volume 7, Issue 6, June 2026.
Here, we provide a comprehensive overview of current technologies and recent advancements in therapeutic target discovery for natural products. By systematically synthesizing the principles, methodologies, and practical applications of existing experimental and computational strategies, this work provides a more actionable reference framework for ...
Qiyuan Pan, Xiao Yuan, Jinmei Jin, Xin Luan, Cheng Luo, Hongzhuan Chen, Weidong Zhang, Hao Zhang   +7 more
wiley   +1 more source

Unveiling the Power of Deuterium in Drug Discovery: A Comprehensive Overview

MedComm, Volume 7, Issue 6, June 2026.
The role of deuterium replacement in drug discovery, its progress, opportunities, and challenges. ABSTRACT Deuterium, the heavy isotope of hydrogen, has unfolded as a cornerstone in modern drug discovery due to its potential to influence metabolic stability and pharmacokinetic behavior.
Mukta Lele, Ajit Manchare, Swapnali Parit, Amol D. Gholap, Krishna Jadhav, Navnath Hatvate, Keshav Raj Paudel, Satish Rojekar   +7 more
wiley   +1 more source