Results 131 to 140 of about 117,925,879 (224)

Coiled Coils as a Programmable Platform for Computational Biosensor Design

ChemBioChem, Volume 27, Issue 21, 12 November 2026.
Coiled coils provide compact, programmable scaffolds for converting molecular recognition and conformational change into biosensor outputs. Their sequence–structure principles are supported by computational design strategies for tuning affinity, orthogonality, switching, and robustness, enabling biosensors that respond to diverse environmental and ...
Paul Kluge, Faezeh Shabani, Sibylle Gemming, Georg Künze   +3 more
wiley   +1 more source

Click Bioconjugation of Aza‐BODIPY Fluorophores to LfcinB Peptides for Improved Biocompatibility

European Journal of Organic Chemistry, Volume 29, Issue 41, 3 November 2026.
Click bioconjugation attaches NIR aza‐BODIPY fluorophores to LfcinB‐derived anticancer peptides via CuAAC and thiol‐maleimide chemistry. Conjugates exhibit improved predicted solubility while retaining strong NIR absorption (703–730 nm). Peptide‐aza‐BODIPY conjugates induce apoptotic morphology in HeLa cancer cells.
A. Verónica Rodríguez‐Mayor, Maricela Morales, Héctor Manuel Pineda‐Castañeda, Zuly Jenny Rivera‐Monroy, Javier Eduardo García‐Castañeda, Norberto Farfán, Rosa Santillan   +6 more
wiley   +1 more source

Autophagy-mediated ID1 turnover dictates chemo-resistant fate in ovarian cancer stem cells

Journal of Experimental & Clinical Cancer Research
Background The mechanisms enabling dynamic shifts between drug-resistant and drug-sensitive states in cancer cells are still underexplored. This study investigated the role of targeted autophagic protein degradation in regulating ovarian cancer stem cell
Pratham Phadte, Aniketh Bishnu, Pranay Dey, Manikandan M, Megha Mehrotra, Prerna Singh, Shritama Chakrabarty, Rounak Majumdar, Bharat Rekhi, Malay Patra, Abhijit De, Pritha Ray   +11 more
doaj   +1 more source

Protein folding in silico : protein folding versus protein structure prediction /

, 2012
Protein folding is a process by which a protein structure assumes its functional shape of conformation, and has been the subject of research since the publication of the first software tool for protein structure prediction.
Roterman-Konieczna, Irena,editor.
core  

Dual‐line Genome‐scale CRISPR Screening Enables Robust Target Gene Discovery

Advanced Science, Volume 13, Issue 61, 3 November 2026.
A species‐optimized CRISPR platform integrates efficient piggyBac delivery, genome‐scale sgRNA libraries, and parallel screening in two independently engineered Bactrocera dorsalis Cas9 cell lines. Cross‐line consensus analysis filters line‐specific effects, enriches candidates with reproducible in vivo phenotypes, and reveals conserved, species ...
Ziniu Li, Jiao Qiao, Qiuyuan Zhang, Peipei Liu, Chenjun Zheng, Qi Zhou, Mengqi Ji, Zhihui Zhu, Xiaoxue Li, Hongyu Zhang   +9 more
wiley   +1 more source

Purification of Advanced Therapeutics by Flow‐Through Pseudo‐Affinity Chromatography: Bi‐Specific mABs, Fc Fusion Proteins, and Adeno‐Associated Viruses

Biotechnology and Bioengineering, Volume 123, Issue 11, Page 3079-3105, November 2026.
ABSTRACT Modern biopharmaceutical manufacturing requires purification platforms capable of processing structurally and functionally diverse products while addressing the challenge of removing persistent and high‐risk host cell proteins (HCPs).
Wenning Chu, Eduardo Barbieri, Arianna Minzoni, Shriarjun Shastry, Jacob P. LeBarre, Qingbo Shu, Taufika Williams, Xuanwen Li, Divya Chandra, Xuankuo Xu, Jerome Bill, David Roush, Joseph Taris, Patrick Gilbert, Andre Kiesewetter, Oliver Rammo, Michael Schulte, Christopher Major, Trina Mouchahoir, Steven Cramer, Cristiana Boi, Ruben G. Carbonell, Abraham Lenhoff, Stefano Menegatti   +23 more
wiley   +1 more source

Targeting Ninjurin‐1‐Mediated Microglial Pyroptosis Attenuates Neuroinflammation and Neuronal Injury Following Intracerebral Hemorrhage

Brain and Behavior, Volume 16, Issue 11, November 2026.
In response to intracerebral hemorrhage, NF‐κB signaling upregulates Nlrp3 and Ninjurin‐1 (Ninj1) in microglia. NLRP3 inflammasome activation triggers GSDMD pore formation, whereas Ninj1 oligomerizes to execute terminal plasma membrane rupture (PMR) and DAMP release (such as HMGB1).
Liqiang Peng, Aosheng Peng, Hui Zhu, Ting Sun, Pan Liu, Ting Qi   +5 more
wiley   +1 more source

Zdhhc14 promotes pyroptosis in the dorsal root ganglion of oxaliplatin‐induced peripheral neuropathy mice by enhancing GBP5 palmitoylation and suppressing its ubiquitination

Clinical and Translational Medicine, Volume 16, Issue 11, November 2026.
Oxaliplatin‐induced up‐regulation of Zdhhc14 enhances GBP5 stability through palmitoylation‐dependent inhibition of ubiquitin–proteasome degradation, thereby contributing to the development of peripheral neuropathy. Zdhhc14 is identified as a key palmitoyltransferase up‐regulated in oxaliplatin‐induced peripheral neuropathy.
Xiao Jiang, Wanqiu Li, Yanzhuo Liu, Wei Song, Xuedan Zheng, Liu Tang   +5 more
wiley   +1 more source

Plant‐Derived Probiotics From Fermented Foods: Current Evidence on Antiviral Mechanisms and Gut–Lung Axis Modulation

Food Frontiers, Volume 7, Issue 6, November 2026.
Plant‐derived probiotics from fermented foods exert anti‐respiratory virus effects via immune regulation, antiviral metabolites, and gut–lung axis, highlighting their advantages, key technologies, and application prospects. ABSTRACT Respiratory viral infections represent a major global public health threat, causing widespread morbidity, mortality, and ...
Yinghao Xing, Yaoyuan Hu, Yingying Ma, Peng Yao, Jingjing Jiang, Jiao Guo, Shuangmei Liu   +6 more
wiley   +1 more source

A New Regulator Caspase‐5C Drives Intestinal Homeostasis by Potentiating Wnt Signaling Through Adenomatous Polyposis Coli (APC) Cleavage

MedComm – Oncology, Volume 5, Issue 4, December 2026.
Lijie He, Sijia Liu, Jiang Ren, Long Zhang   +3 more
wiley   +1 more source