Food-Derived Antihypertensive Peptides: Mechanisms, Multi-Methodological Approaches, Bioavailability, and Functional Food Applications. [PDF]
Ordóñez LC +6 more
europepmc +1 more source
An edge β‐strand mutation turns ubiquitin into a pore‐forming amyloid
Abstract Ubiquitin (Ub) is a highly conserved eukaryotic protein, generally regarded as stable and soluble under physiological conditions, playing a key role in maintaining cellular protein balance. Using complementary bioinformatic, biophysical, immunochemical, and electrophysiological approaches, we show that a single point mutation—the substitution ...
Daniela Meleleo +5 more
wiley +1 more source
<i>In silico</i> design and binding mechanism of UBR1 E3 ligase recruiters. [PDF]
Maria-Solano MA, Lazim R, Choi S.
europepmc +1 more source
Protein design and RNA design: Perspectives
Abstract Advances in deep learning and generative modeling have transformed the landscape of protein and RNA design, enabling rapid and precise creation of novel biomolecules with tailored structures and functions. In protein design, generative deep learning frameworks now support backbone generation, sequence optimization, and joint sequence–structure
Xi Chen, Xu Dai, Peilong Lu
wiley +1 more source
Family-Specialized Transformer for L-cystathionine gamma-lyase Engineering and Its Structural Interpretation. [PDF]
Lee U, Park M, Song B, Ha NC.
europepmc +1 more source
<i>In silico</i> rational investigation of C-terminal arginine-containing white Lupin (<i>Lupinus albus</i>) protein-derived peptides as arginase inhibitors. [PDF]
Chukwuejim S, Fatoki TH, Aluko RE.
europepmc +1 more source
The symbiotic interaction between Demodex folliculorum and Corynebacterium kroppenstedtii subsp. demodicis. Created by the author based on genomic and functional analyses presented in this work. The tripartite interaction between the human host, the mite Demodex folliculorum, and its endosymbiont Corynebacterium kroppenstedtii subsp. demodicis.
T. Steegmüller +6 more
wiley +1 more source
Plant Peptides on the Rise: From Historical Insight to Future Applications
ABSTRACT Plant peptides constitute a rapidly expanding class of signalling molecules essential to plant physiology, mediating key processes such as development, stress adaptation, and immune responses. This review traces the history of plant peptide research, from the seminal discovery of systemin to the recent identification of non‐canonical peptides (
Shunxi Wang +5 more
wiley +1 more source
Advancing DIA-Based Limited Proteolysis Workflows: Introducing DIA-LiPA. [PDF]
Van Leene C +6 more
europepmc +1 more source
ABSTRACT In plants, iron homeostasis and oxygen metabolism are strictly related, indeed several Fe‐requiring enzymes catalyze reactions that also involve O2 as a reagent, product, entry or end point of the pathway. Oxygen sensing itself relies on the Fe‐dependent enzymes Plant cysteine oxidases.
Yuri Telara +9 more
wiley +1 more source

