Results 151 to 160 of about 16,756 (205)

An update on the landscape of collagen bioactive fragments

The FEBS Journal, Volume 293, Issue 13, Page 4064-4084, July 2026.
The remodeling of the extracellular matrix releases collagen bioactive fragments, which exert molecular functions and regulate numerous biological processes via several signaling pathways. Here, we summarize the latest findings describing the roles of major bioactive fragments from collagens I, IV, VI, and XVIII in various physiological and ...
Sylvie Ricard‐Blum, Julie Fradette
wiley   +1 more source

High uPAR and Low miR-221 Expression Predict Poor Disease-Free Survival in Triple-Negative Breast Cancer. [PDF]

Pathophysiology
Gong W, Liu Y, Falkenberg N, Kiechle M, Bronger H, Dorn J, Magdolen V, Dreyer T.   +7 more
europepmc   +1 more source

Degradomics for large‐scale mechanistic insights on proteases and proteolysis in human health

The FEBS Journal, Volume 293, Issue 13, Page 3881-3898, July 2026.
Proteolysis has an important role in human disease but remains relatively unexplored. Degradomics, the uncovering of proteolysis in tissues, cells, and proteins, uses mass spectrometry‐based terminomics to identify protein termini occurring therein (forward degradomics) and to define the actions of proteases (reverse degradomics).
Daniel R. Martin, Sumit Bhutada, Suneel S. Apte   +2 more
wiley   +1 more source

Application of HPSEC Technique and In Silico Analysis in the Evaluation of Bioactive Peptides and Polysaccharide Profile in Wort Supplemented with Malted and Unmalted Hemp Seeds. [PDF]

Molecules
Duliński R, Zdaniewicz M, Byczyński Ł, Żuk-Gołaszewska K, Bukowska B.   +4 more
europepmc   +1 more source

Sesamin Ameliorates High‐Sugar, High‐Fat Diet‐Induced Hepatic Dysfunction via CYP1A2‐Mediated Regulation of Lipid Metabolism and Oxidative Stress

Journal of Cellular and Molecular Medicine, Volume 30, Issue 14, July 2026.
ABSTRACT BackgroundHigh‐sugar, high‐fat diets (HSDFD) can lead to hepatic dysfunction, but the molecular mechanisms underlying protective compounds like sesamin remain unclear MethodsWe employed a multi‐faceted approach combining in silico and in vivo techniques.
Xiliang Zhu, Jie Yan, Qi Liu, Zhaoyun Cheng, Yi Luo   +4 more
wiley   +1 more source

The Role of WWOX Gene Variant in Hypospadias and 46,XY Disorders of Sexual Development. [PDF]

Reprod Sci
Denkboy Ongen Y, Tezcan-Unlu H, Unal U, Efendi-Erdem E, Cecener G, Eren E.   +5 more
europepmc   +1 more source

Rethinking Alzheimer's Disease Therapy: From Amyloid‐Centric Approaches to Multi‐Target Phytochemical Strategies

Journal of Neurochemistry, Volume 170, Issue 7, July 2026.
Alzheimer's disease is driven by interconnected pathological processes, including amyloid‐β aggregation, tau hyperphosphorylation, neuroinflammation, oxidative stress, synaptic dysfunction, and mitochondrial impairment. While recently approved anti‐amyloid therapies represent an important advance, their modest clinical benefits highlight the ...
Emre Aktaş, İlay Yurt, Yağmur Nisa Cerlet, Haşmet Ayhan Hanağası   +3 more
wiley   +1 more source

AI-Based Prediction of PROTAC- and Molecular Glue-Mediated Ternary Complexes: A Comparative Evaluation of AlphaFold 3 and Boltz-2. [PDF]

Arch Pharm (Weinheim)
Riepenhausen L, Sarnow AC, Robaa D, Sippl W.   +3 more
europepmc   +1 more source

Experimental models of cerebral small vessel disease: Physiological constraints, translational challenges and future directions

The Journal of Physiology, Volume 604, Issue 14, Page 5671-5689, 15 July 2026.
Abstract figure legend Overview of cerebral small vessel disease (cSVD) pathophysiology and current modelling challenges. Left: clinical burden and key unresolved research questions. Right: neurovascular unit (NVU) architecture highlighting sites of cSVD pathology across arterioles, capillaries and venules, including interactions between endothelial ...
Sophie Beaumont, Tanya Singh, Luana Campos Soares, Mootaz M. Salman   +3 more
wiley   +1 more source

A Mechanistic Digital Twin of uPAR-Driven Prostate Cancer Invasion Integrating ODE Signalling and Agent-Based Modelling. [PDF]

Pharmaceuticals (Basel)
Dzik R, Chwał J, Tkacz EJ, Roy S, Kabała-Dzik A.   +4 more
europepmc   +1 more source