Clinical and Translational Science, Volume 19, Issue 11, November 2026.ABSTRACT Antibody‐drug conjugates (ADCs) are among the most pharmacologically complex therapeutics in clinical development. Their behavior emerges from the interplay of antibody disposition, linker stability, payload pharmacology, and host physiology—interdependencies that render qualitative descriptors such as “stronger affinity” or “more potent ...
Daniel Bending +4 more
wiley +1 more source
Bioactive Peptides from Andean Crops: Lactic Acid Bacteria Fermentation, Complementary Proteolysis, and Biological Activities. [PDF]
FoodsBarba-Ostria C +5 more
europepmc +1 more source
Molecular Microbiology, Volume 126, Issue 5, Page 596-612, November 2026.MinJ is a nine‐pass transmembrane protein with a cytoplasmic PDZ domain. The PDZ domain, while required for division, is dispensable for localization, and deletion of the transmembrane segments 6 and 7 results in a hyper‐minicell phenotype. ABSTRACT The Min system disassembles FtsZ‐rings after septation in Bacillus subtilis and is localized to the ...
Kehinde O. Adebiyi +5 more
wiley +1 more source
Re-entering the cell: Is the intracellular space the true therapeutic niche for aptamers? [PDF]
Mol Ther Nucleic AcidsGiangrande PH.
europepmc +1 more source
Hitting Coronaviruses Where It Hurts: Antiviral Strategies Targeting Viral Proteins
ChemMedChem, Volume 21, Issue 19, 14 October 2026.Viral proteins represent key vulnerabilities in human coronaviruses (HCoVs). This review outlines inhibitors targeting spike (S), main protease (Mpro), papain‐like protease (PLpro), and RNA‐dependent RNA polymerase (RdRp), mapping chemically diverse strategies that disrupt entry and replication, and provides an integrated view of current candidates ...
Álvaro de la Cruz‐Potenciano +3 more
wiley +1 more source
<i>In Silico</i> Structural Characterization and Hypoglycemic Potential of a Novel Fucose-Specific Lectin (MEP5) from <i>Morchella esculenta</i>. [PDF]
FoodsChen W +5 more
europepmc +1 more source
Searching for Novel COVID19 Treatments: Towards Covalent TMPRSS2 Inhibitors
ChemMedChem, Volume 21, Issue 19, 14 October 2026.We designed, synthesised, and evaluated new guanidine derivatives as potential covalent inhibitors of TMPRSS2, a key protease for SARS‐CoV‐2 entry. Computational studies showed that some compounds have improved binding over nafamostat. However, experimentally none effectively blocked viral entry in cell assays, indicating further optimisation is needed.
Marco Minneci +6 more
wiley +1 more source
ChemMedChem, Volume 21, Issue 19, 14 October 2026.Can simple linker descriptors guide PROTAC design? Analysis of matched CRBN‐ and VHL‐recruiting degraders shows that basic 2D linker properties may capture trends linked to degradation efficiency, in vitro ADME and physicochemical properties. A practical approach to reduce trial‐and‐error in early targeted protein degradation programs. Targeted protein
Giulia Apprato +3 more
wiley +1 more source
Enzymatic Degradation of <i>Cryptosporidium</i> spp. Oocysts: A Combined In Silico and In Vitro Study. [PDF]
MoleculesSouza DCT +8 more
europepmc +1 more source
In Silico and In Vitro Screening and Mechanisms of Angiotensin I-Converting Enzyme Inhibitory Peptides from Protein Hydrolysates of Royal Jelly. [PDF]
FoodsZhang Y, Guo S, Miao H, Gu Y, Zhang J.
europepmc +1 more source