Results 91 to 100 of about 117,925,879 (224)

Conserved SERPINE2 function maintains ovarian estrogen production to support fertility in goats and mice

iMetaOmics, EarlyView.
Single‐nucleus RNA sequencing and functional profiling of goat ovaries with divergent litter sizes revealed prolificacy‐associated granulosa cell (GC) states characterized by enhanced proliferation‐ and steroidogenesis‐related features, together with altered predicted cell–cell communication.
Sanbao Zhang, Yirong Wei, Xiaoping Guo, Ruimen Zhang, Yingming Wei, Yanna Huang, Qinyang Jiang   +6 more
wiley   +1 more source

Proteomics of Nitrotyrosine: Integrating Mass Spectrometry and Immunodetection in Redox‐Driven Pathology

Mass Spectrometry Reviews, EarlyView.
ABSTRACT Nitrooxidative stress, driven by excess reactive nitrogen species like peroxynitrite, contributes to the pathogenesis of many chronic diseases. Among its molecular footprints, 3‐nitrotyrosine (3NT) has emerged as a biologically relevant marker of protein nitration.
Brîndușa Alina Petre
wiley   +1 more source

SERPINA1 and Alpha-1 Antitrypsin: A Review of Molecular Structure, Clinical Variants and Computational Study of Diseases Involving the Protein

BioMed Target Journal
The SERPINA1 gene, located at 14q31-32.3, is responsible for producing Alpha-1 Antitrypsin (AAT), which acts as a serine protease inhibitor to protect tissues from any proteolysis-induced damage.
Afifa Javed, Ayesha Sana Soomro, Shaheer Ali Mughal, Sameer Shahzad, Arleen Yousuf, Imrana Khushk, Abdul Sattar Qureshi   +6 more
doaj   +1 more source

Analysis of Carbohydrates and Glycoconjugates by Matrix‐Assisted Laser Desorption/Ionization Mass Spectrometry: An Update for 2023–2024

Mass Spectrometry Reviews, EarlyView.
ABSTRACT The use of MALDI mass spectrometry for the analysis of carbohydrates and glycoconjugates is a well‐established technique and this comprehensive review is the twelfth update of the original article published in 1999 and brings coverage of the literature to the end of 2024.
David J. Harvey
wiley   +1 more source

Molecular Glue Degraders in Early Development for Cancer Therapy

Medicinal Research Reviews, EarlyView.
ABSTRACT Molecular glue degraders are an emerging class of small molecule allosteric modulators that induce or stabilize protein‐protein interactions, enabling targeted degradation of previously intractable proteins. By redirecting E3 ligases to recognize neosubstrates, proteins that are not typically recognized by a specific E3 ubiquitin ligase, they ...
E. Sila Ozdemir, Hyunbum Jang, Ozlem Keskin, Attila Gursoy, Ruth Nussinov   +4 more
wiley   +1 more source

Top‐Down CSF Peptidomics Reveals Disease‐Associated Peptide Signatures and Oxidative Modifications in Multiple Sclerosis and Neuromyelitis Optica Spectrum Disorder

PROTEOMICS, EarlyView.
ABSTRACT Multiple sclerosis and neuromyelitis optica spectrum disorder (NMOSD) are inflammatory demyelinating diseases of the CNS whose diagnosis is mainly based on clinical evidence, magnetic resonance imaging, and the analysis of cerebrospinal fluid (CSF). Current approaches provide only partial insight into disease‐related biological processes, thus
Cristina Contini, Lorena Lorefice, Greca Lai, Alessandra Schirru, Giorgia Zodio, Tiziana Cabras, Alessandra Olianas, Giacomo Diaz, Eleonora Cocco, Barbara Manconi   +9 more
wiley   +1 more source

Protein Structure and Function Analysis Method of Aminoacyl-tRNA Synthetase Cofactor and Biotinylation Effect: Journal Review

Journal of Experimental Life Science, 2019
Protein has been known as an important macromolecule which has a vital role among the living organism. One of the most interesting protein is Arc1p, which is a yeast-specific tRNA-binding protein.
Restu Nugraha, Chien Chia Wang, Widodo Widodo   +2 more
doaj   +1 more source

amostof/In-silico-model-development-paper: v1.0

<p>The code for the paper "In silico model development and optimization of in vitro lung cell population growth" submitted to PLOS One</p ...
Amirmahdi Mostofinejad
core   +1 more source

The Supporting Scaffold as a Structural Module for Plant Cystatin Design

Proteins: Structure, Function, and Bioinformatics, EarlyView.
ABSTRACT Protein engineering approaches have been proposed to improve the inhibitory potency of cystatins against plant pest digestive Cys proteases, typically involving point mutations in the N‐terminal trunk or inhibitory loops known to interact with the target protease.
Jonathan Tremblay, Kristina LeBreux, Marie‐Claire Goulet, Charles Goulet, Dominique Michaud   +4 more
wiley   +1 more source

A rationally designed peptide targeting trypsin‐like enzymes impairs feeding and redox homeostasis in Anticarsia gemmatalis (Lepidoptera: Erebidae)

Pest Management Science, EarlyView.
GORE3 interacts with digestive proteases in Anticarsia gemmatalis, promoting digestive inhibition, oxidative stress, and midgut cell damage. These physiological disturbances diminish larval survival and feeding damage on soybean plants, emphasizing the potential of GORE3 as a bioinsecticidal peptide for pest control.
Daniel Guimarães Silva Paulo, Eulálio Gutemberg Dias dos Santos, Pablo Fernandes Braga, Geisiane Aparecida Mariano, Wesley Borges Wurlitzer, Julia Renata Shnneider, Milena Godoi Lima, Tauanne Gonçalves Ferreira, Guilherme Faria dos Santos, Rafael Júnior de Andrade, Noeli Juarez Ferla, José Eduardo Serrão, Neilier Rodrigues da Silva Júnior, Humberto Josué Ramos de Oliveira, Maria Goreti de Almeida Oliveira   +14 more
wiley   +1 more source