Results 201 to 205 of about 32,158 (205)

In Silico Screening for Small Molecules to Alter Calpain Proteolysis through Modulating Conformation Changes Induced by Heterodimerization

Journal of Chemical Information and Modeling
Dysregulated calpain-1 and calpain-2 protease activity linked to several diseases has encouraged efforts to explore inhibiting calpain to provide therapeutic benefits. However, there are currently no clinically approved drugs that specifically target calpain functionality.
Pitambar Poudel, Ivan Shapovalov, Shailesh Kumar Panday, Kazem Nouri, Peter L. Davies, Peter A. Greer, Emil Alexov   +6 more
openaire   +2 more sources

[Pharmacological mechanism analysis of oligopeptide from Pinctada fucata based on in silico proteolysis and protein interaction network].

Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica, 2019
Pinctada fucata oligopeptide is one of key pharmaceutical effective constituents of P. fucata. It is significant to analyze its pharmacological effect and mechanism. This study aims to discover the potential oligopeptides from P. fucata and analyze the mechanism of P.
Yan-Kun, Chen, Lian-Sheng, Qiao, Xiao-Qian, Huo, Xu, Zhang, Na, Han, Yan-Ling, Zhang   +5 more
openaire   +3 more sources

[Prediction of ETA oligopeptides antagonists from Glycine max based on in silico proteolysis].

Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica, 2018
Oligopeptides are one of the the key pharmaceutical effective constituents of traditional Chinese medicine(TCM). Systematic study on composition and efficacy of TCM oligopeptides is essential for the analysis of material basis and mechanism of TCM.
Lian-Sheng, Qiao, Lu-di, Jiang, Gang-Gang, Luo, Fang, Lu, Yan-Kun, Chen, Ling-Zhi, Wang, Gong-Yu, Li, Yan-Ling, Zhang   +7 more
openaire   +1 more source

Dynamic characteristics of proteolysis-targeting chimera systems revealed by in silico computations

Current Opinion in Structural Biology
Kexin Xu, Jingxuan Ge, Rongfan Tang, Tingjun Hou, Huiyong Sun   +4 more
openaire   +1 more source

Retraction notice to “In silico proteolysis and molecular interaction of tilapia (Oreochromis niloticus) skin collagen-derived peptides for environmental remediation” [Environ. Res. 212-Part A (2022) 113002]

Environmental Research
Heli Siti Halimatul Munawaroh, Gun Gun Gumilar, Jerlita Dea Berliana, Siti Aisyah, Vidia Afina Nuraini, Andriati Ningrum, Eko Susanto, Larasati Martha, Isman Kurniawan, Nur Akmalia Hidayati, Apurav Krishna Koyande, Pau-Loke Show   +11 more
openaire   +1 more source