Results 61 to 70 of about 32,158 (205)

Insights on a putative aminoacyl-tRNA-protein transferase of Leishmania major. [PDF]

PLoS ONE, 2018
The N-end rule pathway leads to regulated proteolysis as an adaptive response to external stress and is ubiquitous from bacteria to mammals. In this study, we investigated a gene coding for a putative core enzyme of this post-translational regulatory ...
Rohit Sharma, Monica Cristina Terrão, Felipe Freitas Castro, Reinhard Breitling, Vitor Faça, Eduardo Brandt Oliveira, Angela Kaysel Cruz   +6 more
doaj   +1 more source

Translational Considerations for Injectable Biomaterials and Bioscaffolds to Repair and Regenerate Brain Tissue

Advanced Healthcare Materials, EarlyView.
The repair and regeneration of brain tissue faces both biological and technical challenges. Injectable bioscaffolds offer new opportunities to stimulate tissue regrowth in the brain by recruiting neural stem cells. Here, the translational issues are reviewed that need to be address to advance this promising new therapeutic approach from the bench to ...
Michel Modo, Alena Kisel
wiley   +1 more source

Control of RelB during dendritic cell activation integrates canonical and noncanonical NF-κB pathways. [PDF]

, 2012
The NF-κB protein RelB controls dendritic cell (DC) maturation and may be targeted therapeutically to manipulate T cell responses in disease. Here we report that RelB promoted DC activation not as the expected RelB-p52 effector of the noncanonical NF-κB ...
Asagiri, Masataka, Davis-Turak, Jeremy, Fagerlund, Riku, Hoffmann, Alexander, Huang, Jenny Q, Kearns, Jeffrey D, Macal, Monica, Ponomarenko, Julia, Shih, Vincent F-S, Yu, Tony, Zuniga, Elina I   +10 more
core   +2 more sources

Multivalent Protein Nanorings for Broad and Potent SARS‐CoV‐2 Neutralization

Advanced Healthcare Materials, EarlyView.
A protein‐only, modular multivalent nanoscaffold displaying 20 anchor points, decorated with two different binders (10 of each), targeting the SARS‐CoV‐2 receptor‐binding domain is presented. The construct self‐assembles into stable, biocompatible, homogeneous nanoparticles, exhibit synergistic binding with fM IC50 values. It also detects spike at 9 ng 
Molood Behbahanipour, Carla Goldin, Cecilia Arahi Prato, Ana Luz Paletta, Oriol Bárcenas, Susanna Navarro, Jordi Pujols, Daniel H. Murgida, María Virginia Tribulatti, Sebastián Esperante, Damian Alvarez‐Paggi, Salvador Ventura   +11 more
wiley   +1 more source

Evidence That the P\u3csub\u3ei\u3c/sub\u3e Release Event Is the Rate-Limiting Step in the Nitrogenase Catalytic Cycle [PDF]

, 2016
Nitrogenase reduction of dinitrogen (N2) to ammonia (NH3) involves a sequence of events that occur upon the transient association of the reduced Fe protein containing two ATP molecules with the MoFe protein that includes electron transfer, ATP hydrolysis,
Antony, Edwin, Bothner, Brian, Cash, Valerie L., Dean, Dennis R., Eilers, Brian, Guo, Qingjuan, Ledbetter, Rhesa, Pence, Natasha, Peters, John W., Pokhrel, Nilisha, Seefeldt, Lance C., Shaw, Sudipta, Tokmina-Lukaszewska, Monika, Yang, Zhi-Yong   +13 more
core   +1 more source

Direct interaction between EgFABP1, a fatty acid binding protein from echinococcus granulosus, and phospholipid membranes [PDF]

, 2012
<p>Background: Growth and maintenance of hydatid cysts produced by Echinococcus granulosus have a high requirement for host lipids for biosynthetic processes, membrane building and possibly cellular and developmental signalling.
Alvite, G., Corsico, B., Esteves, A., Kennedy, M.W., Porfido, J.L., Silva, V.   +5 more
core   +5 more sources

Redefining Therapies for Drug‐Resistant Tuberculosis: Synergistic Effects of Antimicrobial Peptides, Nanotechnology, and Computational Design

Advanced Healthcare Materials, EarlyView.
Antimicrobial peptide (AMP)‐loaded nanocarriers provide a multifunctional strategy to combat drug‐resistant Mycobacterium tuberculosis. By enhancing intracellular delivery, bypassing efflux pumps, and disrupting bacterial membranes, this platform restores phagolysosome fusion and macrophage function.
Christian S. Carnero Canales, Jessica Ingrid Marquez Cazorla, Renzo Marianito Marquez Cazorla, Aline Martins dos Santos, Jonatas Lobato Duarte, Letícia Oliveira Catarin Nunes, Túlio Custódio Reis, Lara Cerazi Salvador, Norival Alves Santos‐Filho, Rafael Miguel Sábio, Hélder A. Santos, Fernando Rogério Pavan   +11 more
wiley   +1 more source

Thalidomide-Based PROTACs: A Viable Strategy Against Trypanosomatids?

Drugs and Drug Candidates
Background: In recent years, compounds known as Proteolysis Targeted Chimeras (PROTACs) have revitalized the field of bioactive molecule design. These compounds promote proteolysis of therapeutic targets by recruiting them to ubiquitin ligases.
Romina Manarin, Gianfranco Frattini, Victoria L. Alonso, Victoria Boselli, Giselle R. Bedogni, Elvio Rodríguez Araya, Diego M. Moreno, Esteban Serra   +7 more
doaj   +1 more source

Peptides, specific proteolysis products, as molecular markers of allergenic proteins - in silico studies.

Acta scientiarum polonorum. Technologia alimentaria, 2014
The objective of this study was to analyse allergenic proteins by identifying their molecular biomarkers for detection in food using bioinformatics tools. The protein and epitope sequences were from BIOPEP database, proteolysis was simulated using BIOPEP program and UniProt database screening via BLAST and FASTA programs.
Marta, Dziuba, Piotr, Minkiewicz, Marianna, Dąbek   +2 more
openaire   +1 more source

Opposite effects of two zinc(II) dithiocarbamates on NF-kB pathway [PDF]

, 2007
Inhibiting nuclear factor-kappaB (NF-kB) activation in anticancer and antiinflammatory therapy is of topical interest. Current research in molecular biology has dramatically advanced in the understanding of the cellular events involved in NF-kB induction.
Boris Cvek, Jan Taraba, Jitka Ulrichova, Lukas Muller, Radim Vrzal, Zdenek Dvorak   +5 more
core   +2 more sources