Results 41 to 50 of about 117,925,879 (224)

Ssn6-Tup1 global transcriptional co-repressor: Role of the N-terminal glutamine-rich region of Ssn6. [PDF]

PLoS ONE, 2017
The Ssn6-Tup1 complex is a general transcriptional co-repressor formed by the interaction of Ssn6, a tetratricopeptide repeat (TPR) protein, with the Tup1 repressor.
Athanassios Tartas, Christoforos Zarkadas, Maria Palaiomylitou, Niki Gounalaki, Dimitris Tzamarias, Metaxia Vlassi   +5 more
doaj   +1 more source

Going viral − Virus‐targeting nanobodies for research, diagnostics and therapy

FEBS Letters, EarlyView.
The increasing prevalence of viral diseases represents a major threat for global human health. Nanobodies, small binding fragments derived from camelid heavy‐chain antibodies, offer versatile tools for viral research, diagnostics, and antiviral therapy.
Domenic Ebert, Ulrich Rothbauer
wiley   +1 more source

Mining Bovine Milk Proteins for DPP-4 Inhibitory Peptides Using Machine Learning and Virtual Proteolysis

Research
Dipeptidyl peptidase-IV (DPP-4) enzyme inhibitors are a promising category of diabetes medications. Bioactive peptides, particularly those derived from bovine milk proteins, play crucial roles in inhibiting the DPP-4 enzyme.
Yiyun Zhang, Yiqing Zhu, Xin Bao, Zijian Dai, Qun Shen, Liyang Wang, Yong Xue   +6 more
doaj   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Regulated intramembrane proteolysis and degradation of murine epithelial cell adhesion molecule mEpCAM. [PDF]

PLoS ONE, 2013
Epithelial cell adhesion molecule EpCAM is a transmembrane glycoprotein, which is highly and frequently expressed in carcinomas and (cancer-)stem cells, and which plays an important role in the regulation of stem cell pluripotency.
Matthias Hachmeister, Karolina D Bobowski, Sebastian Hogl, Bastian Dislich, Akio Fukumori, Carola Eggert, Brigitte Mack, Heidi Kremling, Sannia Sarrach, Fabian Coscia, Wolfgang Zimmermann, Harald Steiner, Stefan F Lichtenthaler, Olivier Gires   +13 more
doaj   +1 more source

Proteolysis in septic shock patients: plasma peptidomic patterns are associated with mortality [PDF]

, 2018
Background: Uncontrolled proteolysis contributes to cell injury and organ dysfunction in animal models of circulatory shock. We investigated in humans the relationship between septic shock, proteolysis, and outcome.
E. B. Kistler, Herpain, A, V. Ribas, Schmid-Schönbein, Geert G.W., Tedeschi, G, Schmid-Schönbein, G.W., G. Tedeschi, A. Herpain, M. A. Odena, Herpain, A., Schmid-Schönbein, GW, Aletti, Federico, R. Díaz, Romay, Eduardo, F. Aletti, E. R. Medina, Pinto, BB, Ribas, V, R. Ferrer, Ribas, V., Kistler, E.B., Bendjelid, Karim, Aletti, F., Odena, María Antonia, E. de Oliveira, de Oliveira, Eliandre, Ferrer, Ricard, de Oliveira, E, Bauzá-Martinez, J., Romay, E., de Oliveira, E., Odena, MA, Ferrer, R., Ferrer, R, J. Bauzá-Martinez, Kistler, EB, G. W. Schmid-Schönbein, Díaz, Ramón, Díaz, R, Bauzá-Martinez, J, Bendjelid, K, B. B. Pinto, Tedeschi, G., Ribas, Vicent, Romay, E, Kistler, Erik E.B., Tedeschi, Gabriella, K. Bendjelid, Díaz, R., Odena, M.A., Herpain, Antoine, Aletti, F, Bollen Pinto, Bernardo, Bendjelid K, Bauzá-Martinez J, Odena MA, de Oliveira E, Díaz R, Ferrer R, Pinto BB, Aletti F, Ribas V, Kistler EB, Tedeschi G, Romay E, Schmid-Schönbein GW, Herpain A   +66 more
core   +1 more source

Charting Endocrine Progenitors Across Species and Organs

Advanced Science, EarlyView.
Endocrine progenitors give rise to the hormone‐producing cells of the pancreas and intestine. Using single‐cell multiomics and proteomics, this study compares these progenitors across species, systems, and organs, mapping the conserved and species‐specific gene regulatory networks that guide their formation.
Changying Jing, Michael Sterr, Özüm Sehnaz Caliskan, Lama Saber, Nicole Katarina Rogers, Samuel Ogden, Kei Kozawa, Christos Karampelias, Jessica Jaki, Aimée Bastidas‐Ponce, Falk Janos Farkas, Oliver Czarnecki, Osvaldo Rodrigues Pereira, Perla Cota, Valerie Vandenbempt, Diego Balboa, Anika Böttcher, Natalie Krahmer, Mohammad Lotfollahi, Julie B. Sneddon, Heiko Lickert, Mostafa Bakhti   +21 more
wiley   +1 more source

High-resolution analysis and functional mapping of cleavage sites and substrate proteins of furin in the human proteome. [PDF]

PLoS ONE, 2013
There is a growing appreciation of the role of proteolytic processes in human health and disease, but tools for analysis of such processes on a proteome-wide scale are limited. Furin is a ubiquitous proprotein convertase that cleaves after basic residues
Sergey A Shiryaev, Andrei V Chernov, Vladislav S Golubkov, Elliot R Thomsen, Eugene Chudin, Mark S Chee, Igor A Kozlov, Alex Y Strongin, Piotr Cieplak   +8 more
doaj   +1 more source

Proteolysis in soft cheese, studied on Meshanger cheese and cheese models [PDF]

, 1978
Enzymes predominantly responsible for the primary degradation of protein in soft cheese and for the related changes in consistency were studied. Reconstructed Noordhollandse Meshanger cheese and preserved simulated soft cheeses of different composition ...
Noomen, A.
core  

Deep Learning‐Driven Discovery and Engineering of an Efficient PETase for Depolymerization and Detoxification of PET Microplastics Under Physiological Conditions

Advanced Science, EarlyView.
A deep learning–driven pipeline mining 246 million protein sequences uncovers AhPETase, an evolutionarily distinct PET hydrolase. Engineered variant AhPETaseM1 degrades post‐consumer PET microplastics under physiological conditions and reverses microplasticinduced cytotoxicity in human lung and colon cells, establishing enzymatic microplastic ...
Yuxuan Wang, Shijie He, Yuheng Chang, Sheng Mao, Jianan Canal Li, Binbin Chen, Hongxun Gao, Mingchun Xu, Chenxu Liu, Yajie Wang   +9 more
wiley   +1 more source