Results 31 to 40 of about 16,993 (213)

Proteolysis in septic shock patients: plasma peptidomic patterns are associated with mortality [PDF]

, 2018
Background: Uncontrolled proteolysis contributes to cell injury and organ dysfunction in animal models of circulatory shock. We investigated in humans the relationship between septic shock, proteolysis, and outcome.
E. B. Kistler, Herpain, A, V. Ribas, Schmid-Schönbein, Geert G.W., Tedeschi, G, Schmid-Schönbein, G.W., G. Tedeschi, A. Herpain, M. A. Odena, Herpain, A., Schmid-Schönbein, GW, Aletti, Federico, R. Díaz, Romay, Eduardo, F. Aletti, E. R. Medina, Pinto, BB, Ribas, V, R. Ferrer, Ribas, V., Kistler, E.B., Bendjelid, Karim, Aletti, F., Odena, María Antonia, E. de Oliveira, de Oliveira, Eliandre, Ferrer, Ricard, de Oliveira, E, Bauzá-Martinez, J., Romay, E., de Oliveira, E., Odena, MA, Ferrer, R., Ferrer, R, J. Bauzá-Martinez, Kistler, EB, G. W. Schmid-Schönbein, Díaz, Ramón, Díaz, R, Bauzá-Martinez, J, Bendjelid, K, B. B. Pinto, Tedeschi, G., Ribas, Vicent, Romay, E, Kistler, Erik E.B., Tedeschi, Gabriella, K. Bendjelid, Díaz, R., Odena, M.A., Herpain, Antoine, Aletti, F, Bollen Pinto, Bernardo   +52 more
core   +1 more source

Function of SYDE C2-RhoGAP family as signaling hubs for neuronal development deduced by computational analysis

Scientific Reports, 2022
Recent investigations of neurological developmental disorders have revealed the Rho-family modulators such as Syde and its interactors as the candidate genes.
Zen Kouchi, Masaki Kojima
doaj   +1 more source

Soybean (Glycine max) Protein Hydrolysates as Sources of Peptide Bitter-Tasting Indicators: An Analysis Based on Hybrid and Fragmentomic Approaches

Applied Sciences, 2020
The aim of this study was to analyze soybean proteins as sources of peptides likely to be bitter using fragmentomic and hybrid approaches involving in silico and in vitro studies.
Anna Iwaniak, Monika Hrynkiewicz, Piotr Minkiewicz, Justyna Bucholska, Małgorzata Darewicz   +4 more
doaj   +1 more source

Peptides derived from gp43, the most antigenic protein from Paracoccidioides brasiliensis, form amyloid fibrils in vitro: implications for vaccine development

Scientific Reports, 2021
Fungal infection is an important health problem in Latin America, and in Brazil in particular. Paracoccidioides (mainly P. brasiliensis and P. lutzii) is responsible for paracoccidioidomycosis, a disease that affects mainly the lungs.
Thyago R. Cardim-Pires, Ricardo Sant’Anna, Debora Foguel   +2 more
doaj   +1 more source

Antioxidant Properties and Prediction of Bioactive Peptides Produced from Flixweed (sophia, Descurainis sophia L.) and Camelina (Camelina sativa (L.) Crantz) Seed Meal: Integrated In Vitro and In Silico Studies

Plants, 2023
Flixweed (sophia) seed meal and camelina, both by-products of oil processing, were employed to generate protein hydrolysates by applying Flavourzyme and Alcalase. This study aimed to integrate in vitro and in silico methods to analyze sophia and camelina
Na Thi Ty Ngo, Tharindu R. L. Senadheera, Fereidoon Shahidi   +2 more
doaj   +1 more source

Antigen processing and presentation in cancer immunotherapy

Journal for ImmunoTherapy of Cancer, 2020
Background Knowledge about and identification of T cell tumor antigens may inform the development of T cell receptor-engineered adoptive cell transfer or personalized cancer vaccine immunotherapy.
Maxwell Y Lee, Cem Sievers, Clint T Allen, Jun W Jeon   +3 more
doaj   +1 more source

Identification of Antibacterial Peptide Candidates Encrypted in Stress-Related and Metabolic Saccharomyces cerevisiae Proteins

Pharmaceuticals, 2022
The protein-rich nature of Saccharomyces cerevisiae has led this yeast to the spotlight concerning the search for antimicrobial peptides. Herein, a
Maria Fernanda da Silva Santos, Cyntia Silva Freitas, Giovani Carlo Verissimo da Costa, Patricia Ribeiro Pereira, Vania Margaret Flosi Paschoalin   +4 more
doaj   +1 more source

New compounds from heterocyclic amines scaffold with multitarget inhibitory activity on Aβ aggregation, AChE, and BACE1 in the Alzheimer disease

PLoS ONE, 2022
The preset neurodegenerations in Alzheimer disease (AD) are due to several mechanisms such as amyloidogenic proteolysis, neuroinflammation, mitochondrial dysfunction, neurofibrillary tangles, cholinergic dysfunction, among others.
Iohanan Daniel García Marín, Raúl Horacio Camarillo López, Oscar Aurelio Martínez, Itzia Irene Padilla-Martínez, José Correa-Basurto, Martha Cecilia Rosales-Hernández   +5 more
doaj   +2 more sources

MODELLING THE INFLUENCE OF NUCLEUS ELASTICITY ON CELL INVASION IN FIBER NETWORKS AND MICROCHANNELS [PDF]

, 2013
Cell migration in highly constrained extracellular matrices is exploited in scaffold-based tissue engineering and is fundamental in a wide variety of physiological and pathological phenomena, among others in cancer invasion and development. Research into
Scianna, Marco, Preziosi, Luigi
core   +1 more source

In Silico Identification of Antimicrobial Peptides in the Proteomes of Goat and Sheep Milk and Feta Cheese

Proteomes, 2019
Milk and dairy products are a major functional food group of growing scientific and commercial interest due to their nutritional value and bioactive “load”. A major fraction of the latter is attributed to milk’s rich protein content and
Marios Tomazou, Anastasis Oulas, Athanasios K. Anagnostopoulos, George Th. Tsangaris, George M. Spyrou   +4 more
doaj   +1 more source