Results 11 to 20 of about 16,993 (213)
Molecules, 2022 This study explores utilization of a sustainable soybean by-product (okara) based on in silico approach. In silico approaches, as well as the BIOPEP database, PeptideRanker database, Peptide Calculator database (Pepcalc), ToxinPred database, and AllerTop
Andriati Ningrum +8 more
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Computer aided drug design in the development of proteolysis targeting chimeras
Computational and Structural Biotechnology Journal, 2023 Proteolysis targeting chimeras represent a class of drug molecules with a number of attractive properties, most notably a potential to work for targets that, so far, have been in-accessible for conventional small molecule inhibitors.
Tin M. Tunjic +2 more
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An in silico and in vitro approach to elucidate the impact of residues flanking the cleavage scissile bonds of FVIII. [PDF]
PLoS ONE, 2017 Coagulation Factor VIII is activated by an ordered limited thrombin proteolysis with different catalytic efficiency at three P1 Arginine residues: Arg759> Arg1708>Arg391, indicating the flanking residues of the latter to be less optimal. This study aimed
Behnaz Pezeshkpoor +7 more
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Marine Drugs, 2022 Bioinformatic tools are widely used in predicting potent bioactive peptides from food derived materials. This study was focused on utilizing sea cucumber processing by-products for generating antioxidant and ACE inhibitory peptides by application of a ...
Tharindu R. L. Senadheera +3 more
doaj +2 more sources
Online tools to support teaching and training activities in chemical engineering: enzymatic proteolysis [PDF]
Frontiers in Education, 2023 The practical teaching or training of enzymatic proteolysis can prove challenging because of the lengthy duration of the process, the complexity of identifying short amino acid sequences, the high cost of the enzymes, and the need to use very specific ...
Silvia Villaró-Cos +3 more
doaj +4 more sources
Catalysts, 2023 Despite their potential as a protein source for human consumption, the health benefits of black soldier fly larvae (BSFL) proteins following human gastrointestinal (GI) digestion are poorly understood. This computational study explored the potential of BSFL proteins to release healthpromoting peptides after human GI digestion.
Chai, Tsun-Thai +4 more
core +6 more sources
ResearchDipeptidyl peptidase-IV (DPP-4) enzyme inhibitors are a promising category of diabetes medications. Bioactive peptides, particularly those derived from bovine milk proteins, play crucial roles in inhibiting the DPP-4 enzyme.
Yiyun Zhang +6 more
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In-silico structural and functional characterization of a V. cholerae O395 hypothetical protein containing a PDZ1 and an uncommon protease domain. [PDF]
PLoS ONE, 2013 Vibrio cholerae, the causative agent of epidemic cholera, has been a constant source of concern for decades. It has constantly evolved itself in order to survive the changing environment.
Avirup Dutta +2 more
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Specific inhibitors of urokinase plasminogen activator for treatment of cancers; In silico approach
Translation, 2020 Invasion, metastasis and angiogenesis are fundamental processes in the development of solid cancers. All these depend on the proteolysis where plasminogen activation system (PAS) is the prominent component.
Benjamin Talbot, Jerzy Jankun
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Foods, 2023 The unique processing technology of dry-cured meat products leads to strong proteolysis, which produces numerous peptides. The purpose of this investigation was the systematic isolation, purification, and identification of potentially cardioprotective ...
Mingming Li +7 more
doaj +2 more sources