Results 11 to 20 of about 114,045,296 (248)

In Silico Identification of Antimicrobial Peptides in the Proteomes of Goat and Sheep Milk and Feta Cheese

Proteomes, 2019
Milk and dairy products are a major functional food group of growing scientific and commercial interest due to their nutritional value and bioactive “load”. A major fraction of the latter is attributed to milk’s rich protein content and
Athanasios K Anagnostopoulos, Marios Tomazou, George M Spyrou   +2 more
exaly   +3 more sources

Identification and In Silico Simulation on Inhibitory Platelet-Activating Factor Acetyl Hydrolase Peptides from Dry-Cured Pork Coppa

Foods, 2023
The unique processing technology of dry-cured meat products leads to strong proteolysis, which produces numerous peptides. The purpose of this investigation was the systematic isolation, purification, and identification of potentially cardioprotective ...
Mingming Li, Xin Zhang, Jiapeng Li, Linggao Liu, Qiujin Zhu, Chao Qu, Yunhan Zhang, Shouwei Wang   +7 more
doaj   +2 more sources

Antihypertensive Peptide ENWAAL Derived from Coix Glutelin and Its Effect on the Expression of SHR Renin–Angiotensin System [PDF]

Biomolecules
Hypertension is one major risk factor of cardiovascular diseases, and RAS plays vital role during the development of hypertension. To obtain a novel antihypertensive peptide, Coix glutelin was hydrolyzed by trypsin and further separated by Sephadex G10 ...
Wenjing Zhang, Jinjie Liang, Yiping Li, Yong Yang, Haiying Chen, Liansheng Qiao, Lingzhi Wang   +6 more
doaj   +2 more sources

<i>In silico</i> rational investigation of C-terminal arginine-containing white Lupin (<i>Lupinus albus</i>) protein-derived peptides as arginase inhibitors. [PDF]

Food Chem (Oxf)
Arginase is a binuclear manganese metalloenzyme that modulates L-arginine availability and downstream metabolic pathways. It was hypothesized that C-terminal arginine-containing peptides generated through simulated gastrointestinal digestion of white ...
Chukwuejim S, Fatoki TH, Aluko RE.
europepmc   +2 more sources

In Silico Tools to Extract the Drug Design Information Content of Degradation Data: The Case of PROTACs Targeting the Androgen Receptor

Molecules, 2023
Proteolysis-Targeting Chimeras (PROTACs) have recently emerged as a promising technology in the drug discovery landscape. Large interest in the degradation of the androgen receptor (AR) as a new anti-prostatic cancer strategy has resulted in several ...
Giulia Apprato, Giulia D’Agostini, Paolo Rossetti, Giuseppe Ermondi, Giulia Caron   +4 more
doaj   +2 more sources

Retraction notice to "In silico proteolysis and molecular interaction of tilapia (Oreochromis niloticus) skin collagen-derived peptides for environmental remediation" [Environ. Res. 212-Part A (2022) 113002].

Environmental Research
Heli Siti Halimatul Munawaroh, Gun Gun Gumilar, Jerlita Dea Berliana, S. Aisyah, Vidia A Nuraini, A. Ningrum, E. Susanto, Larasati Martha, I. Kurniawan, N. A. Hidayati, A. Koyande, Pau-Loke Show   +11 more
semanticscholar   +3 more sources

Plant-Derived Proteins and Peptides as Potential Immunomodulators

Molecules, 2023
The immune response of humans may be modulated by certain biopeptides. The present study aimed to determine the immunomodulatory potential of plant-derived food proteins and hydrolysates obtained from these proteins via monocatalytic in silico hydrolysis
Iwona Szerszunowicz, Szymon Kozicki
doaj   +1 more source

Zinc metalloproteinases and amyloid Beta-Peptide metabolism : the positive side of proteolysis in Alzheimer's disease [PDF]

, 2011
Alzheimer's disease is a neurodegenerative condition characterized by an accumulation of toxic amyloid beta- (Aβ-)peptides in the brain causing progressive neuronal death.
Gough, Mallory, Parr-Sturgess, Catherine, Parkin, Edward   +2 more
core   +5 more sources

In Silico Approach of Glycinin and Conglycinin Chains of Soybean By-Product (Okara) Using Papain and Bromelain

Molecules, 2022
This study explores utilization of a sustainable soybean by-product (okara) based on in silico approach. In silico approaches, as well as the BIOPEP database, PeptideRanker database, Peptide Calculator database (Pepcalc), ToxinPred database, and AllerTop
Andriati Ningrum, Dian Wahyu Wardani, Nurul Vanidia, Achmat Sarifudin, Rima Kumalasari, Riyanti Ekafitri, Dita Kristanti, Woro Setiaboma, Heli Siti Halimatul Munawaroh   +8 more
doaj   +1 more source

Computer aided drug design in the development of proteolysis targeting chimeras

Computational and Structural Biotechnology Journal, 2023
Proteolysis targeting chimeras represent a class of drug molecules with a number of attractive properties, most notably a potential to work for targets that, so far, have been in-accessible for conventional small molecule inhibitors.
Tin M. Tunjic, Noah Weber, Michael Brunsteiner   +2 more
doaj   +1 more source