Unlocking Antimicrobial Peptides: In Silico Proteolysis and Artificial Intelligence-Driven Discovery from Cnidarian Omics [PDF]
MoleculesOvercoming the growing challenge of antimicrobial resistance (AMR), which affects millions of people worldwide, has driven attention for the exploration of marine-derived antimicrobial peptides (AMPs) for innovative solutions. Cnidarians, such as corals,
Ricardo Alexandre Barroso +2 more
exaly +7 more sources
Discovery of Anti-Hypertensive Oligopeptides from Adlay Based on In Silico Proteolysis and Virtual Screening [PDF]
International Journal of Molecular Sciences, 2016 Adlay (Coix larchryma-jobi L.) was the commonly used Traditional Chinese Medicine (TCM) with high content of seed storage protein. The hydrolyzed bioactive oligopeptides of adlay have been proven to be anti-hypertensive effective components. However, the structures and anti-hypertensive mechanism of bioactive oligopeptides from adlay were not clear. To
Liansheng Qiao, Yankun Chen, Fang Lu
exaly +6 more sources
Novel dipeptidyl peptidase‐IV and angiotensin‐I‐converting enzyme inhibitory peptides released from quinoa protein by in silico proteolysis [PDF]
Food Science and Nutrition, 2020 AbstractQuinoa protein has been paid more and more attention because of its nutritional properties and beneficial effects. With the development of bioinformatics, bioactive peptide database and computer‐assisted simulation provide an efficient and time‐saving method for the theoretical estimation of potential bioactivities of protein.
Huimin Guo, Aurore Richel, Xin Fan
exaly +7 more sources
Potential Biological Activities of Peptides Generated during Casein Proteolysis by Curly Kale (Brassica oleracea L. var. sabellica L.) Leaf Extract: An In Silico Preliminary Study [PDF]
Foods, 2021 This study is a brief report on the proteolytic activity of curly kale leaf extract against casein. Casein degradation products and an in silico analysis of the biological activity of the peptides obtained was performed.
Magdalena Polak-Berecka +5 more
doaj +4 more sources
In silico proteolysis and analysis of bioactive peptides from sequences of fatty acid desaturase 3 (FAD3) of flaxseed protein. [PDF]
Saudi J Biol Sci, 2021 Flaxseed (Linum usitatissimum), commonly known as linseed is an oilseed crop, emerging as an important and functional ingredient of food and has been paid more attention due to its nutritional value as well as beneficial effects. It is mainly rich in is α-linolenic acid (ALA, omega-3 fatty acid), fibres and lignans that have potential health benefits ...
Langyan S +7 more
europepmc +3 more sources
A Model of Demasking and Hydrolysis of Peptide Bonds During Tryptic Digestion of β-Casein and β-Lactoglobulin [PDF]
MoleculesThe prediction of polypeptide chain fragmentation during digestion (proteolysis) of protein substrates by trypsin was carried out for globular β-lactoglobulin (β-LG) and micellar β-casein (β-CN).
Mikhail M. Vorob’ev
doaj +2 more sources
Characteristics of Biopeptides Released In Silico from Collagens Using Quantitative Parameters
Foods, 2020 The potential of collagens to release biopeptides was evaluated using the BIOPEP-UWM-implemented quantitative criteria including the frequency of the release of fragments with a given activity by selected enzyme(s) (AE), relative frequency of release of ...
Anna Iwaniak +2 more
exaly +3 more sources
Identification of Novel Umami Peptides from Yak Bone Collagen and Mechanism Exploration Through In Silico Discovery, Molecular Docking, and Electronic Tongue [PDF]
FoodsUmami peptides were screened and identified from yak bone collagen for the first time by in silico analysis, molecular docking, and electronic tongue.
Yimeng Mei +9 more
doaj +2 more sources
IP Indian Journal of Clinical and Experimental DermatologySkin diseases represent a significant burden on global healthcare systems, with protein deposition playing a pivotal role in their pathogenesis, including conditions such as macular amyloidosis. This study aimed to assess the proteolytic activity of the enzyme Papain on deposited protein, offering insights into potential therapeutic strategies.
Vrushali Neve +4 more
exaly +2 more sources
Plant-Derived Proteins and Peptides as Potential Immunomodulators
Molecules, 2023 The immune response of humans may be modulated by certain biopeptides. The present study aimed to determine the immunomodulatory potential of plant-derived food proteins and hydrolysates obtained from these proteins via monocatalytic in silico hydrolysis
Iwona Szerszunowicz, Szymon Kozicki
doaj +1 more source