Unlocking Antimicrobial Peptides: In Silico Proteolysis and Artificial Intelligence-Driven Discovery From Cnidarian Omics [PDF]
MoleculesOvercoming the growing challenge of antimicrobial resistance (AMR), which affects millions of people worldwide, has driven attention for the exploration of marine-derived antimicrobial peptides (AMPs) for innovative solutions. Cnidarians, such as corals,
Agostinho Antunes +2 more
exaly +4 more sources
A Model of Demasking and Hydrolysis of Peptide Bonds During Tryptic Digestion of β-Casein and β-Lactoglobulin [PDF]
MoleculesThe prediction of polypeptide chain fragmentation during digestion (proteolysis) of protein substrates by trypsin was carried out for globular β-lactoglobulin (β-LG) and micellar β-casein (β-CN).
Mikhail M. Vorob’ev
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Characteristics of Biopeptides Released in Silico From Collagens Using Quantitative Parameters
Foods, 2020 The potential of collagens to release biopeptides was evaluated using the BIOPEP-UWM-implemented quantitative criteria including the frequency of the release of fragments with a given activity by selected enzyme(s) (AE), relative frequency of release of ...
Anna Iwaniak +2 more
exaly +3 more sources
Antihypertensive Peptide ENWAAL Derived from Coix Glutelin and Its Effect on the Expression of SHR Renin–Angiotensin System [PDF]
BiomoleculesHypertension is one major risk factor of cardiovascular diseases, and RAS plays vital role during the development of hypertension. To obtain a novel antihypertensive peptide, Coix glutelin was hydrolyzed by trypsin and further separated by Sephadex G10 ...
Wenjing Zhang +6 more
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Novel Dipeptidyl Peptidase-IV and Angiotensin-I-Converting Enzyme Inhibitory Peptides Released From Quinoa Protein by in Silico Proteolysis [PDF]
Food Science and Nutrition, 2020 Nadia Everaert, Huimin Guo, Guixing Ren
exaly +2 more sources
Discovery of Anti-Hypertensive Oligopeptides From Adlay Based on in Silico Proteolysis and Virtual Screening [PDF]
International Journal of Molecular Sciences, 2016 Liansheng Qiao +2 more
exaly +2 more sources
Identification of Novel Umami Peptides from Yak Bone Collagen and Mechanism Exploration Through In Silico Discovery, Molecular Docking, and Electronic Tongue [PDF]
FoodsUmami peptides were screened and identified from yak bone collagen for the first time by in silico analysis, molecular docking, and electronic tongue.
Yimeng Mei +9 more
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Plant-Derived Proteins and Peptides as Potential Immunomodulators
Molecules, 2023 The immune response of humans may be modulated by certain biopeptides. The present study aimed to determine the immunomodulatory potential of plant-derived food proteins and hydrolysates obtained from these proteins via monocatalytic in silico hydrolysis
Iwona Szerszunowicz, Szymon Kozicki
doaj +1 more source
Molecules, 2022 This study explores utilization of a sustainable soybean by-product (okara) based on in silico approach. In silico approaches, as well as the BIOPEP database, PeptideRanker database, Peptide Calculator database (Pepcalc), ToxinPred database, and AllerTop
Andriati Ningrum +8 more
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Computer aided drug design in the development of proteolysis targeting chimeras
Computational and Structural Biotechnology Journal, 2023 Proteolysis targeting chimeras represent a class of drug molecules with a number of attractive properties, most notably a potential to work for targets that, so far, have been in-accessible for conventional small molecule inhibitors.
Tin M. Tunjic +2 more
doaj +1 more source