Results 21 to 30 of about 16,993 (213)

Regulated intramembrane proteolysis and degradation of murine epithelial cell adhesion molecule mEpCAM. [PDF]

PLoS ONE, 2013
Epithelial cell adhesion molecule EpCAM is a transmembrane glycoprotein, which is highly and frequently expressed in carcinomas and (cancer-)stem cells, and which plays an important role in the regulation of stem cell pluripotency.
Matthias Hachmeister, Karolina D Bobowski, Sebastian Hogl, Bastian Dislich, Akio Fukumori, Carola Eggert, Brigitte Mack, Heidi Kremling, Sannia Sarrach, Fabian Coscia, Wolfgang Zimmermann, Harald Steiner, Stefan F Lichtenthaler, Olivier Gires   +13 more
doaj   +3 more sources

Flavan‐3‐ol Microbial Metabolites Modulate Proteolysis in Neuronal Cells Reducing Amyloid‐beta (1‐42) Levels [PDF]

, 2021
INTRODUCTION: Alzheimer's disease (AD) is a progressive neurodegeneration characterized by extensive protein aggregation and deposition in the brain, associated with defective proteasomal and autophagic‐lysosomal proteolytic pathways. Since current drugs
Eleuteri, Anna Maria, Valentina Cecarini, Chunmei Gong, Cuccioloni, Massimiliano, Gong, Chunmei, Mena, Pedro, Del Rio, Daniele, Angeletti, Mauro, Bonfili, Laura, Daniele Del Rio, Cecarini, Valentina, Anna Maria Eleuteri, Yadong Zheng, Laura Bonfili, Mauro Angeletti, Massimiliano Cuccioloni, Zheng, Yadong, Pedro Mena   +17 more
core   +3 more sources

Unraveling the Role of Linker Design in Proteolysis Targeting Chimeras [PDF]

, 2021
A current bottleneck in the development of proteolysis targeting chimeras (PROTACs) is the empirical nature of linker length structure-activity relationships (SARs). A multidisciplinary approach to alleviate the bottleneck is detailed here.
Bemis, Troy A, La Clair, James J, Burkart, Michael D   +2 more
core   +1 more source

In silico and in vitro assessment of yellowfin tuna skin (Thunnus albacares) hydrolysate antioxidation effect

Food Hydrocolloids for Health, 2023
The protein hydrolysate that contains bioactive peptides of yellowfin tuna (Thunnus albacares) skin collagen with antioxidant activity has been successfully studied by using in silico and in vitro assays. We found that using the in silico assessment, the
Dian Wahyu Wardani, Andriati Ningrum, Manikharda, Nurul Vanidia, Heli Siti Helimatul Munawaroh, Eko Susanto, Pau-Loke Show   +6 more
doaj   +1 more source

Discovery of a Highly Potent and Selective Degrader Targeting Hematopoietic Prostaglandin D Synthase via In Silico Design

, 2021
Targeted protein degradation by proteolysis-targeting chimera (PROTAC) is one of the exciting modalities for drug discovery and biological discovery. It is important to select an appropriate linker, an E3 ligase ligand, and a target protein ligand in the
Norihito Shibata (4170250), Kiyonaga Fujii (535302), Yosuke Demizu (1537882), Yuta Yanase (11570099), Kosuke Aritake (3592007), Mikihiko Naito (511409), Yuki Murakami (8128800), Hidetomo Yokoo (9987836), Kengo Hamamura (11570102), Takahito Ito (8614497), Yasushi Saeki (3682096), Akinori Endo (407408)   +11 more
core   +5 more sources

Characteristics of Potential Protein Nutraceuticals of Plant Origin with Antioxidant Activity

Molecules, 2020
This study used selected plant proteins and the tools available in the BIOPEP-UWM database to profile proteins and release antioxidant nutraceuticals from their primary structures. The frequency of the occurrence of fragments with antioxidant activity in
Iwona Szerszunowicz, Jan Kłobukowski
doaj   +1 more source

Linking collective in vitro to individual in silico peptide bioactivity through mass spectrometry (LC-Q-TOF/MS) based sequence identification: the case of black cumin protein hydrolysates

, 2021
Black cumin (Nigella sativaL.) is a seed that has been utilized in traditional medicine due to the bioactive characteristics of seed oil and therein solubilized components. In the present study, using enzymatic proteolysis (0-2 h) and fast protein liquid
Zent, Inci, Cakir, Bilal, Goksu, Ayse Gulden, Gulseren, Ibrahim   +3 more
core   +3 more sources

Green seaweed Ulva lactuca, a potential source of bioactive peptides revealed by in silico analysis

Informatics in Medicine Unlocked, 2022
The green seaweed Ulva lactuca is found in coastal areas. Potential bioactive peptides have a wide range of uses, including antibacterial, antifungal, antiviral, alpha-amylase inhibitory, antiamnestic, ACE inhibitory, immunomodulatory, anticancer ...
Md.Ariful Amin, Uzzal Chondra, Ethneen Mostafa, Md.Morshedul Alam   +3 more
doaj   +1 more source

The use of UniProtKB/BIOPEP for the analysis of oat globulin physicochemical parameters and bioactivity

Czech Journal of Food Sciences, 2018
The physico-chemical properties of oat proteins (globulins) were determined and an analysis was done whether products of in silico proteolysis contain mono- and multi-functional peptides with various biological activity.
Iwona SZERSZUNOWICZ, Dorota NAŁĘCZ
doaj   +1 more source

Evaluation of Antioxidant Activities from a Sustainable Source of Okara Protein Hydrolysate Using Enzymatic Reaction

Molecules, 2023
Okara is a solid byproduct created during the processing of soy milk. The production of protein hydrolysates utilizing enzymatic tests such as papain can result in the production of bioactive peptides (BPs), which are amino acid sequences that can also ...
Andriati Ningrum, Dian Wahyu Wardani, Nurul Vanidia, Manikharda, Achmat Sarifudin, Rima Kumalasari, Riyanti Ekafitri, Dita Kristanti, Woro Setiaboma, Heli Siti Helimatul Munawaroh   +9 more
doaj   +1 more source