Results 101 to 110 of about 112,390 (279)

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

Training the in silico trials workforce

This deliverable presents the developed lecture material in the format of mini-courses per stakeholder group and its test results. Besides, courses that are missing in the current curricula were identified for stakeholder groups in training. For each of these courses, a syllabus was developed with concrete guidelines for frontal lectures as well as ...
Gheysen, Lise, Vander Sloten, Jos
openaire   +2 more sources

Super‐Refractory Status Epilepticus (SRSE) in a Patient With Compound Heterozygous OPA1 Variants: Case Report and Literature Review

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Super‐Refractory Status Epilepticus (SRSE) is a rare, life‐threatening neurological emergency with unclear etiology in many cases. Mitochondrial dysfunction, often due to disease‐causing genetic variants, is increasingly recognized as a cause, with each gene producing distinct pathophysiological mechanisms.
Pouria Mohammadi, Lara Basovic, Christopher Michael McGraw   +2 more
wiley   +1 more source

Experimental and theoretical assessment of salvianolic acid B, ellagic acid, and phorbol esters as drug candidates against breast and prostate cancer

Discover Chemistry
Global efforts to develop innovative anti-cancer lead compounds from natural compounds found in plants have gained advanced momentum, focusing on achieving Sustainable Development Goal (SDG) number 3 on good health and well-being.
Russell B. O. Ouma, Usama Raza, Silas M. Ngari, Joshua K. Kibet, Uzair Nisar, Muhammad Waqar Ali   +5 more
doaj   +1 more source

In situ tumor model for longitudinal in silico imaging trials

Physics in Medicine & Biology
Abstract Objective. In this article, we introduce a computational model for simulating the growth of breast cancer lesions accounting for the stiffness of surrounding anatomical structures. Approach. In our model, ligaments are classified as the most rigid structures while the softer parts of the breast are occupied by
Aunnasha Sengupta, Miguel A Lago, Aldo Badano   +2 more
openaire   +2 more sources

Real‐World Performance of CSF Kappa Free Light Chains in the 2024 McDonald Criteria

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Kappa free light chains (KFLCs) in the cerebrospinal fluid (CSF) have a similar performance to CSF‐restricted oligoclonal bands (OCB) for multiple sclerosis (MS) diagnosis. To help with implementation, we set out to resolve several remaining uncertainties: (1) performance in a real‐world cohort and the 2024 McDonald criteria; (2 ...
Maya M. Leibowitz, Ryan Cooper, Stefania Kaninia, Kathryn I. Challis, Will Greenway, Maria Bonello, Mahmoud Elbahnasawi, Deborah T. Shode, Dominika Gajdasik, Victor Iliev, Alison M. E. Whitelegg, Ian Galea   +11 more
wiley   +1 more source

Multiscale physics-based in silico modelling of nanocarrier-assisted intravascular drug delivery

Frontiers in Drug Delivery
A rational design of drug nanocarriers supported by in silico modelling tools can improve the efficacy of nanosystem-based intravascular drug delivery (IVDD).
Nicolae-Viorel Buchete, Nicolae-Viorel Buchete, Iwona Cicha, Sutapa Dutta, Sutapa Dutta, Panagiotis Neofytou   +5 more
doaj   +1 more source

Strategies for identifying exact structure of neural circuits with broad light microscopy connectivity probes [PDF]

, 2008
Dissecting the structure of neural circuits in the brain is one of the central problems of neuroscience. Until present day, the only way to obtain complete and detailed reconstructions of neural circuits was thought to be the serial section Electron ...
Yuriy Mishchenko
core   +1 more source

Developmental and Epileptic Encephalopathy due to Biallelic Pathogenic Variants in PIGM

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective PIGM encodes a critical enzyme in the glycosylphosphatidylinositol (GPI)‐anchor biosynthesis pathway. While promoter‐region mutations in PIGM have been associated with a relatively mild phenotype characterized by portal vein thrombosis and absence seizures, recent evidence suggests that coding‐region mutations result in a more severe
Júlia Sala‐Coromina, Anna Marcé‐Grau, Barbara Masotto, Marta Codina, Lamia BenJemaa, Yasmina Elaribi, Mónica Martinez‐Gallo, Roger Colobran, Angel Sanchez‐Montañez, Irene Valenzuela, Yoshiko Murakami, Alfons Macaya   +11 more
wiley   +1 more source

Gastrointestinal endogenous proteins as a source of bioactive peptides : Doctor of Philosophy in Nutritional Sciences at Riddet Institute, Massey University, Palmerston North, New Zealand [PDF]

, 2016
Gastrointestinal endogenous proteins (GEP) were investigated as a source of bioactive peptides. In silico and in vitro methods were used singly or in combination to study GEP-derived peptides after simulated digestion.
Acharya, Prasannalakshmi
core