Results 231 to 240 of about 112,390 (279)

Structural analysis of catalase from two Musa accessions, FHIA18 and Williams, and from Ravenala madagascariensis [PDF]

, 2008
Jaufeerally-Fakim, Y., Khroyratty, S.S.S., Souza, M.T.   +2 more
core   +1 more source

AI‐Driven Cancer Multi‐Omics: A Review From the Data Pipeline Perspective

Advanced Intelligent Discovery, EarlyView.
The exponential growth of cancer multi‐omics data brings opportunities and challenges for precision oncology. This review systematically examines AI's role in addressing these challenges, covering generative models, integration architectures, Explainable AI for clinical trust, clinical applications, and key directions for clinical translation.
Shilong Liu, Shunxiang Li, Kun Qian
wiley   +1 more source

Modernising antiviral drug discovery: harnessing medicinal plants through machine learning and metabolomics to target the SARS-CoV-2 main protease. [PDF]

In Silico Pharmacol
Msobo A, Maphari PW, Koorsen G, Singab ANB, Mhlongo MI.   +4 more
europepmc   +1 more source

AS‐pHopt: An Optimal pH Prediction Model Enhanced by Active Site of Enzymes

Advanced Intelligent Discovery, EarlyView.
To address the low accuracy of enzyme optimal pH (pHopt) prediction, this study develops active site‐based pHopt (AS‐pHopt), a prediction model enhanced by active site information and pseudo‐label prediction. Integrating key structural and physicochemical features affecting enzyme pHopt, AS‐pHopt uses Evolutionary Scale Modeling (ESM)‐2 with active ...
Wenxiang Song, Xinmin Li, Hongbo Yu, Le Xiong, Guixia Liu, Weihua Li, Yun Tang   +6 more
wiley   +1 more source

Accelerating Discovery of Organic Molecular Crystals via Materials Informatics and Autonomous Experiments

Advanced Intelligent Discovery, EarlyView.
Materials informatics and autonomous experimentation are transforming the discovery of organic molecular crystals. This review presents an integrated molecule–crystal–function–optimization workflow combining machine learning, crystal structure prediction, and Bayesian optimization with robotic platforms.
Takuya Taniguchi, Kazuki Ishizaki, Ryo Fukasawa   +2 more
wiley   +1 more source

Functional bipartite invariance in mouse primary visual cortex receptive fields. [PDF]

Nat Neurosci
Ding Z, Tran D, Ponder K, Ding Z, Froebe R, Ntanavara L, Fahey PG, Cobos E, Baroni L, Diamantaki M, Wang EY, Chang A, Papadopoulos S, Fu J, Muhammad T, Papadopoulos C, Cadena SA, Evangelou A, Willeke K, Anselmi F, Sanborn S, Antolik J, Froudarakis E, Patel S, Walker EY, Reimer J, Sinz FH, Ecker AS, Franke K, Pitkow X, Tolias AS.   +30 more
europepmc   +1 more source

An in silico clinical stroke trial computing environment

An in silico clinical stroke trial computing ...
openaire   +1 more source

OXidative Stress PREDictor: A Supervised Learning Approach for Annotating Cellular Oxidative Stress States in Inflammatory Cells

Advanced Intelligent Systems, Volume 7, Issue 3, March 2025.
OxSpred, an eXtreme‐Gradient‐Boosting‐‐based supervised learning model, accurately annotates oxidative stress in innate immune cells at the single‐cell level, providing interpretable embeddings with significant biological relevance. This innovative tool revolutionizes the understanding of innate immune cell functions during inflammation and enhances ...
Po‐Yuan Chen, Tai‐Ming Ko
wiley   +1 more source

In silico high-resolution whole lung model to predict the locally delivered dose of inhaled drugs. [PDF]

Commun Med (Lond)
Grill MJ, Biehler J, Wichmann KR, Richter J, Rixner M, Rudlstorfer D, Brei M, Rehfeldt JL, Hofer JA, Bügel J, Pischke N, Wall WA, Müller KW.   +12 more
europepmc   +1 more source

Routing Optimization of Cable‐Driven Octopus‐Inspired Manipulators With Minimal Actuation via Genetic Algorithm and Finite Element Method

Advanced Intelligent Systems, EarlyView.
Soft robotic arms are promising for gentle grasping but often rely on bulky actuation systems. This work presents a computational design framework that optimizes tendon number and routing to achieve target grasps with fewer actuators. Validated on an octopus‐inspired underwater arm, the approach enables efficient, underactuated soft manipulators for ...
Michele Martini, Emanuele Solfiti, Alessio Mondini, Emanuela Del Dottore, Alberto Parmiggiani, Edoardo Sinibaldi, Barbara Mazzolai   +6 more
wiley   +1 more source